Filtyp
sing an integrative approach in which genetic variation, gene expression, and clinical phenotypes are assessed in relevant tissues may help functionally characterize the contribution of genetics to disease susceptibility. We sought to identify genetic variation influencing skeletal muscle gene expression (expression quantitative trait loci [eQTLs]) as well as expression associated with measures of
Background: Autism spectrum disorders (ASD) are severe neurodevelopmental disorders with the male:female ratio of 4:1, implying the contribution of X chromosome genetic factors to the susceptibility of ASD. The ribosomal protein L10 (RPL10) gene, located on chromosome Xq28, codes for a key protein in assembling large ribosomal subunit and protein synthesis. Two non-synonymous mutations of RPL10,
Throughout the last decade, there has been an increased interest in various forms of dynamic epistemic logics to model the flow of information and the effect this flow has on knowledge in multi-agent systems. This enterprise, however, has mostly been applicationally and semantically driven. This results in a limited amount of proof theory for dynamic epistemic logics. In this paper, we try to com
Evaluation of Specific Absorption Rate (SAR) for multiple antenna systems is becoming important, with the upcoming deployment of LTE-Advanced. In this work, the influence of different antenna locations and antenna types was investigated for stand-alone SAR and simultaneous SAR, to provide some guidelines for antenna design in multi-antenna handsets. For simultaneous SAR, different phase shifts bet
Migratory movements in air or water are strongly affected by wind and ocean currents and an animal which does not compensate for lateral flow will be drifted from its intended direction of movement. We investigated whether arctic shorebirds during autumn migration in the region of South Sweden and the southern Baltic Sea compensate for wind drift or allow themselves to be drifted when approaching
Human group IIA-secreted phospholipase A(2) (sPLA(2)-IIA) is a bactericidal molecule important for the innate immune defense against Gram-positive bacteria. In this study, we analyzed its role in the host defense against Streptococcus pyogenes, a major human pathogen, and demonstrated that this bacterium has evolved a previously unidentified mechanism to resist killing by sPLA(2)-IIA. Analysis of
This anthology, written in English and German, is a report from the symposium "Richard Wagner - Werk und Wirkungen / His Works and their Impact" held in Stockholm, 27-29 January, 2013, arranged by the Royal Swedish Academy of Letters, History and Antiquities, together with the Royal Swedish Academy of Music, the Royal Swedish Opera, and the University College of Opera in Stockholm. The authors off
S100B is a dimeric protein that can form tetramers, hexamers and higher order oligomers. These forms have been suggested to play a role in RAGE activation.
Abstract is not available
Energy usage and its associated costs have taken on a new level of significance in recent years. Globally, energy costs that include the cooling of server rooms are now comparable to hardware costs, and these costs are on the increase with the rising cost of energy. As a result, there are efforts worldwide to design more efficient scheduling algorithms. Such scheduling algorithm for grids is furth
Thin semitransparent gels were prepared by radical copolymerization of N-acryloyl-m-aminophenylboronic acid (NAAPBA) and acrylamide (AAm) taken in molar ratios from 8:92 to 16:84, respectively, in water. The gels were characterized by the content of immobilized NAAPBA and monomer conversion. Scanning electron microscopy revealed the micrometer size pores in the dried gels. The wet gels displayed a
Serglycin is a proteoglycan expressed by some malignant cells. It promotes metastasis and protects some tumor cells from complement system attack. In the present study, we show for the first time the in situ expression of serglycin by breast cancer cells by immunohistochemistry in patients' material. Moreover, we demonstrate high expression and constitutive secretion of serglycin in the aggressive
In this study we investigate the effect of programmed cross-flows on the error in the hydrodynamic radii (r(h)) determination with asymmetrical flow field-flow fractionation (AsFlFFF). Three different standard polystyrene particles (nominal radii of 30 and 40 and 50nm) are fractionated with exponentially and linearly decaying cross-flows with different decay rates. Hydrodynamic radii are calculate
Long term effects after peptic ulcer surgery still exert an influence on some patient groups. Partial gastrectomy increases the risk of gastric carcinoma more than 20 years after surgery and enterogastric reflux is regarded as the main ethiological factor. Partial gastrectomy also gives increased risk of other malignancies as well as smoking related disease. Parietal cell vagotomy (PCV) is conside
The NICE trial was designed to evaluate the possible benefits of adding epidermal growth factor receptor targeted therapy to neoadjuvant chemotherapy in patients with estrogen receptor alpha (ER) negative and operable breast cancer. Preclinical data have suggested that signalling through the ErbB receptors or downstream effectors may repress ER expression. Here the authors investigated whether gef
