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Prostate cancer is a highly heterogeneous disease, understanding the crosstalk between complex genomic and epigenomic alterations will aid in developing targeted therapeutics. We demonstrate that, even though snail family transcriptional repressor 2 (SNAI2) is frequently amplified in prostate cancer, it is epigenetically silenced in this disease, with dynamic changes in SNAI2 levels showing distin
IMPORTANCE: Luminal and basal subtypes of primary prostate cancer have been shown to be molecularly distinct and clinically important in predicting response to therapy. These subtypes have not been described in metastatic prostate cancer.OBJECTIVES: To identify clinical and molecular correlates of luminal and basal subtypes in metastatic castration-resistant prostate cancer (mCRPC) and investigate
We are now in an era of molecular medicine, where specific DNA alterations can be used to identify patients who will respond to specific drugs. However, there are only a handful of clinically used predictive biomarkers in oncology. Herein, we describe an approach utilizing in vitro DNA and RNA sequencing and drug response data to create TreAtment Response Generalized Elastic-neT Signatures (TARGET
Detection of toxic hexavalent chromium in soil, groundwater, industrial effluent, etc., is of significant interest. We demonstrate the electrochemical detection of Cr(VI) using a surface-engineered mesoporous carbon-based material. The mesoporous carbon-based material is obtained by the controlled pyrolysis of a homogenous mixture of Fe and Co complexes of hydrolyzed collagen. The as-synthesized m
Thanks to superionic conductivity and compatibility with >4 V cathodes, halide solid electrolytes (SEs) have elicited tremendous interest for application in all-solid-state lithium batteries (ASSLBs). Many compositions based on groups 3, 13, and divalent metals, and substituted stoichiometries have been explored, some displaying requisite properties, but the Li+ conductivity still falls shor
Interfacial stability issues at the cathode remain a bottleneck to developing durable and high-power all-solid-state lithium batteries (ASSLBs). In fact, the presence of conductive carbon in the cathode, necessary for high capacity and power capability, is believed to aggravate the stability woes. Thus, it is typically excluded from the cathode mix. Herein, employing a model functionalized ca
H+ co-intercalation chemistry of the cathode is perceived to have damaging consequences on the low-rate and long-term cycling of aqueous zinc batteries, which is a critical hindrance to their promise for stationary storage applications. Herein, the thermodynamically competitive H+ storage chemistry of an attractive high-voltage cathode LiMn2O4 is revealed by employing operando and ex-situ anal
Advancement of aqueous zinc-ion batteries (AZIBs) for practical application is limited due to the inferior performance of the existing cathode. Herein, we demonstrate rational design and synthesis of an oxygen vacancy-rich low-valent vanadium-based spinel cathode (OV-ZnV2O4) for the fabrication of high-performance AZIBs. ZnV2O4 having an urchin-like morphology with nanorods ∼19 nm in diameter
Cathode–solid electrolyte (SE) interfacial stability issues pose a significant challenge to stable and high-power operations of all-solid-state batteries, which promise greater energy density, thermal stability, and safety than the current liquid electrolyte-based Li-ion technology. For technologically important Ni-rich NMCs (LiNixMnyCozO2 or NMCxyz; x/y/z: Ni/Mn/Co stoichiometry) with sulfid
Aqueous zinc-ion batteries have emerged as strong contenders for sustainable energy storage; however, their widespread adoption is constrained by sluggish Zn2+ transport and suboptimal cathode performance. A rapid, energy-efficient solvothermal synthesis of Na2V6O16 is reported, and introduces cation vacancies via initial electrochemical engineering. This electrochemical pre-treatment generat
The rapid expansion of the global microgrid (MG) market requires a sustainable and resilient energy storage solution to manage the intermittent nature of renewable energy sources. While conventional battery storage systems are common, they present significant limitations in cost, lifespan, and environmental impact. This paper introduces green hydrogen energy storage (GHES) as a paradigm-shifting a
BackgroundTo enable immunotherapy for ovarian cancers, precision targets for immune priming as well as patient stratification approaches are required. The tumor microenvironment in particularly the rare subtypes of low-grade serous, mucinous, clear cell and endometrioid ovarian cancer, remains poorly characterized, and these tumors have been largely ignored in the immuno-oncology setting.MethodsWe
The diffusion of water and the cross relaxation between water and cellulose in a hydrated paper system were followed with the Goldman-Shen and the pulsed-field-gradient stimulated-echo NMR pulse sequences as a function of moisture content. The diffusion coefficient measured along the plane of the paper sheet is very sensitive to the moisture content; more water leads to faster diffusion. The cress
