Sökresultat

Introduction. The sixth edition of the Transatlantic Orthopedic Surgery Webinar was held on March 3rd 2025, focusing on the comprehensive management of neuromuscular scoliosis in children with cerebral palsy (CP). The event brought together leading experts from Europe, North America, and Australia, representing centers of excellence in pediatric orthopedics and neuromuscular care. The initial sess

Achieving a robust ignition with minimal spark plug wear is challenging in heavy duty engines fueled with gaseous fuels like biogas and hydrogen. Thermal energy deposition from the spark to the gas was studied in a 10.9 milliliter custom-built spark calorimeter. An AC capacitive ignition system was used along with a dual-nickel standard J-gap spark plug and the influence of multiple physical and e

This response to Alister McGrath’s The Nature of Christian Doctrine examines the interplay between Scripture, the Rule of Faith, and evolving Christian doctrine and tradition. Focusing on McGrath’s critique of Lindbeck’s presentation of doctrinal modalities, the article explores how doctrinal formation involves primarily synchronic (canonical), but also diachronic (historical), approaches to scrip

A diet low in fermentable oligo-, di-, and monosaccharides and polyols (FODMAP) and a starch- and sucrose-reduced diet (SSRD) both alleviate symptoms in IBS. Our hypothesis was that restrictive diets may preserve good nutritional supply. The aims of the study were to compare nutritional intake between SSRD and low FODMAP, and correlations between changes in nutrient intake, weight, and symptoms. T

Studies on mantle cell lymphoma (MCL) emphasize that patients with progression of disease (POD) ≤24 months have inferior prognosis compared to patients with later POD. This population-based study assessed the impact of POD on overall survival (OS) by timing of progression and first-line treatment. A total of 1186 MCL patients diagnosed 2006–2018 were identified in the Swedish lymphoma register. PO

The transition to a circular economy challenges existing regulatory frameworks, social norms, and belief systems: the dominant institutions. Moving from a linear to circular business model (CBM) is essential for sustainable business transformation. While CBMs have been widely studied in Europe, less is known about their emergence in the United States, where a national circular economy policy is st

This study investigates properties of mastics produced with 70/100 neat bitumen, three mineral fillers (granite, quartz-granite, and diorite), and a lime-based active filler at filler-to-bitumen (F/B) ratios of 40%, 50%, and 60%. The physical, geometrical, and mineralogical properties of the fillers were assessed. Their influence on mastics' behaviour was evaluated using conventional penetration a

This study aims to explore the mechanism through which Yishen Jiangtang Decoction (YSJTD) regulates endoplasmic reticulum stress (ERS)-mediated NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome to improve diabetic nephropathy (DN) in db/ db mice. Thirty db/ db mice were randomly divided into the model group, YSJTD group, ERS inhibitor 4-phenylbutyric acid (4-PBA) g

Background: Pancreatic cancer continues to retain the highest mortality rate among all major organ cancers. New strategies for early detection are being proposed to increase long-term survival. A plethora of molecular markers are discovered yearly, but so far none have demonstrated screening utility. Summary: Promising discovery technologies include affinity-based proteomics and ddPCR. In the vali

We present a genome assembly from an individual female Podarcis tiliguerta (Tyrrhenian Wall Lizard; Chordata; Lepidosauria; Squamata; Lacertidae). The assembly contains two haplotypes with total lengths of 1 462.31 megabases and 1 394.94 megabases. Most of haplotype 1 (99.26%) is scaffolded into 20 chromosomal pseudomolecules, including the W and Z sex chromosomes. Most of haplotype 2 (99.2%) is s

Background: Minimising time from injury to hospital admission is considered a key factor in trauma. Trauma care is often centralised to hospitals, which, because of their urban location, make treatment more accessible to patients in densely populated areas. If prehospital time increases with declining population density, an effect on mortality could hence be present. The primary aim of this study

Background: Individuals with diabetes (DM) are often treated with statins, which have a rare side effect: peripheral neuropathy. We aimed to study whether statin treatment affects the risk of carpal tunnel syndrome (CTS) and ulnar nerve entrapment (UNE) in type 2 DM (T2DM). Methods: We combined multiple national registers in Sweden to identify individuals diagnosed with CTS or UNE in specialized c

Synthetic Data Generation (SDG) based on Artificial Intelligence (AI) can transform the way clinical medicine is delivered by overcoming privacy barriers that currently render clinical data sharing difficult. This is the key to accelerating the development of digital tools contributing to enhanced patient safety. Such tools include robust data-driven clinical decision support systems, and example-

Droplets are sophisticated micro-compartments crucial for lab-on-a-chip and bio-medical applications. There have been significant efforts towards generating monodisperse droplets as the uniformity of droplets affects performance. Recently, we introduced a new method to continuously reform existing emulsions improving monodispersity in an ultrasound-actuated microcavity via a trap-coalesce-split me

Gamification is an increasingly popular topic in manufacturing research, since it can enhance workers’ engagement and reduce their errors. Manufacturing is a traditionally male-dominated industry, however females face greater risks compared to their male counterparts, and the number of highly skilled female workers is increasing. This contribution presents the results from the pre-test of a gamifi

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease with a heterogenous clinical picture. This study aimed to link genetic SLE predisposition with relevant clinical manifestations. Method: Datasets best corresponding to the 11 American College of Rheumatology 1982 (ACR-82) classification criteria for SLE in a large, public database (FinnGen consortium, >218,000 individuals) wer

Background: Creatinine-based estimated glomerular filtration rate (eGFR) equations are widely used in clinical practice but exhibit inherent limitations. On the other side, measuring GFR is time consuming and not available in routine clinical practice. We developed and validated machine learning models to assess the trustworthiness (i.e. the ability of equations to estimate measured GFR (mGFR) wit

Background: Early evidence suggests beta-blockers may have a disease-modifying effect in hereditary haemorrhagic telangiectasia (HHT). We aimed to assess the efficacy of oral propranolol is reducing severity of HHT-related epistaxis. Methods: A randomised, double blind, placebo controlled clinical trial was conducted in adults with HHT experiencing epistaxis. Subjects were randomly assigned to rec

Background and Aims. While the rationale for coronavirus disease 2019 (COVID-19) vaccination is to reduce complications and overall mortality, some cardiovascular complications from the vaccine itself have been demonstrated. Myocarditis and pericarditis are recognized as rare acute adverse events after mRNA vaccines in young males, while evidence regarding other cardiovascular events remains limit

In multiple myeloma (MM), advancements in treatments and toxicity management have enhanced survival rates. This, coupled with shifting age demographics in MM, necessitates an updated assessment of infection risks in MM patients compared to the general population. Using Swedish population-based registries, we investigated the incidence of infections in 8,672 Swedish symptomatic MM patients diagnose