Cellmodell för analys av Tau klumpar vid Alzheimers sjukdom Sjukdomar som drabbar hjärnan kan klassas som neurodegenerativa och ge olika symptom, exempelvis demens, svårt med finmotorik och svårt att finna ord. Både Alzheimers sjukdom och Parkinsons sjukdom delar dessa symptom, fastän det finns olika bakomliggande orsaker. Denna sammankoppling mellan olika neurodegenerativa sjukdomars symptom pekAlzheimer’s disease is classified as a neurodegenerative disease and have the misfolding and aggregation of the protein Tau as an underlying cause. Tau loses its regular function to support the cytoskeleton and to protect DNA and RNA. The loss of function results in prion-like spread where regular Tau can bind and add to the formation of fibrils or neurofibrillary tangles. The aim with this thes

The Fms-like tyrosine kinase 3 (FLT3) mutation, especially FLT3- internal tandem duplications (FLT3-ITD), is common in AML and associated with poor prognosis and resistance to therapy. This study explores an alternative approach by investigating the role of MicroRNA-155 (miR-155) in AML, known for its oncogenic properties. Previous research has linked miR-155 to poor AML prognosis, particularly in

This master’s thesis investigates the development and suggestion of a model for adapting and revising the technology strategies concerning Stationary Charging Stations (SCS), based on insights from relevant markets and stakeholders. This study particularly focuses on High-Tech Stationary Charging Stations in the Electric Vehicle (EV) charging industry, emphasizing Elonroad’s new Stationary Chargin

Mutualistic interactions between, for example, plants and pollinators play a crucial role in maintaining the biodiversity of ecosystems, while non-pollinating insects (exploiters) that exploit plants are commonly thought to have destabilizing effects. The long-term, i.e., evolutionary time scale, effects of such potential destabilization is however largely unknown. The eco-evolutionary implication

Den som tittar noggrant upptäcker ofta hur samma djur- eller växtart kan ha varierande former, till exempel utseenden och färger. Bland det vanligaste fenomenet är tydliga könsskillnader mellan hane och hona, eller sexuell dimorfism där hanen vanligtvis är större, har ornament eller är mer färgglad jämfört med honor. Detta går även att observera bland insekter där honor och hanar varierar i färg oSex-limited polymorphism is an interesting evolutionary phenomenon, which is widespread across organisms. Studying ultimate mechanisms that result in the evolution of sex-limited polymorphism can provide a window into how natural and/or sexual selection can result in the evolution of complex phenotypes. Here, I use butterflies from the tribe Polyommatini to study the evolutionary mode and tempo of

In the past decade, problematic school absenteeism has become a well-known concept in society and research. This study aims to research professionals’ perspectives on problematic school absences in elementary school and high school, and their alternative solutions and thoughts about preventative work. The study is conducted by several semi-structured interviews with six professionals who work or h

Bakgrund: Tidigare forskning har visat på låg kunskap gällande fertilitet, i synnerhet hos unga män. Medelåldern för förstagångsföräldrar ökar och man kan se att personer senarelägger barnafödandet till förmån för utbildning och karriär. Med bakgrund av detta har en internationell expertgrupp utvecklat en poster med fertilitetsrelaterad information: “Vill du ha barn i framtiden? Nio saker som kan

Syftet med denna studie var att undersöka om de fyra dimensionerna av identitetsledarskap (prototypikalitet, avancemang, entreprenörskap och direktörskap) predicerade olika former av socialt stöd (upplevt stöd från närmaste chef och stöd från medarbetare) samt social gemenskap på arbetsplatsen. Insamlingen av data utfördes i Sverige i form av en digital enkätundersökning som besvarades av personerThe purpose of this study was to examine if the four dimensions of identity leadership (prototypicality, advancement, entrepreneurship and impresarioship) could predict different forms of social support (perceived supervisorial support and collegial support) as well as social community in the workplace. The data was collected in Sweden through a digital survey which was answered by people who had

Bakgrund: Aktivitet och delaktighet är viktigt för hälsa och välbefinnande. En funktionsnedsättning kan medföra inskränkt delaktighet i fritidsaktiviteter. Fritidshjälpmedlet Joëlette, kan beskrivas som en en-hjulad rullstol med två handtag fram och bak. Joëlette används för att möjliggöra för personer med funktionsnedsättning att delta i turer i naturen. Bara ett fåtal tidigare studier finnsBackground: Activity and participation are important for health and wellbeing. A disability may lead to limited participation in leisure activities. The assistive device Joëlette can be described as a one-wheeled wheelchair with two handles at the front and back. Joëlette is used to enable persons with disabilities to participate in tours in nature. Only a few previous studies exist on similar as

This thesis investigates the inflationary impact of the European Electricity Market on its member countries, including the EU28, Norway, and Switzerland, from 2003 to 2019. The research question particularly focuses on whether this market impacts the level of inflation in its net exporting member countries. Utilising two panel data regression models, we explore the market's impact on the rate

Refusal to work is a term that falls under misconduct concerning termination and dismissal. The employee and the employer each have obligations due to the employment relationship. Refusal to work can be a breach of the duty of loyalty and thereby a breach of the employment contract. There is no clear definition of refusal to work in Swedish legislation, why this essay aims to investigate the meani

As the amount of high dimensional data becomes increasingly accessible and common, the need for reliable methods to combat problems such as overfitting and multicollinearity increases. Models need to be able to manage large data sets where predictor variables often outnumber the amount of observations. In this study the frequentist and Bayesian framework is tested against each other based on three

In 2017 the Swedish government issued an official report containing proposed changes to the compulsory care legislation to strengthen the child rights perspective and provide extended knowledge to the workers within psychiatry. The aim of this study was therefore to examine the reasoning regarding the proposed changes in the comment letters following the official report of the Swedish government:

Abstract Tesfa Abdisa Afan Oromo and Code-switching - Mixing Amharic into Afan Oromo Kandidatuppsats SOCK10 15 hp Handledare – Axel Fredholm Sociologiska institutionen, höstterminen 2023 This study is about code-switching or mixing Amharic with Afan Oromo in Ethiopia. The writer of this essay was born and grew up in Oromia and lived with the issue in question. This language question was creat

This study aimed to examine the mental health of students at the School of Social Work at Lund University and see how it connects to the use of student health resources offered by the university. This study was based on a digital survey that had been sent out to social work students at Lund University. The data we collected was analyzed with George Engel’s biopsychosocial model. The results of our

Ett av de viktigaste målen inom experimentell fysik, om inte det viktigaste, är att utföra precisa mätningar för att nå bästa möjliga resultat. Inom högenergifysik görs mätningarna med hjälp av specialbyggda detektorer som bland annat finns vid världens största partikelaccelerator the Large Hadron Collider (LHC). Vid LHC utförs flera experiment och ett av dessa är A Large Ion Collider Experiment This thesis deals with the physics performance of an approved inner tracker upgrade of the ALICE experiment involving a novel and ultra-thin silicon detector with a cylindrical geometry. During the thesis work, a method was developed in simulations to induce distortions to the detector’s geometry, and the resulting loss in physics performance was evaluated. A strategy was also developed to be able

Our study aimed to, through a qualitative content analysis, understand how violence manifests among young women aged 16-25 in their romantic relationships, as well as how violence affects their social lives. By listening to six podcasts, watching three short film clips, and reading three written texts, we have gained insights into personal stories from young women's own experiences of violence

Följande uppsats behandlar det svenska ridsportförbundet och vilka rättssäkerhetsprinciper som appliceras i dess beslut. För att få en bättre helhetsbild av vad rättssäkerhet innebär så kommer det inledningsvis att redogöras för de svenska rättssäkerhetsprinciper som appliceras i en domstol, för att sedan besvara uppsatsens syfte med hjälp av det material som framlagts. Ridsports världen har tidigThe following essay deals with the Swedish Equestrian Federation and the legal principles of due process applied in its decisions. To gain a better understanding of what due process entails, the essay will initially outline the Swedish due process principles applied in a court of law. Subsequently, the essay will address the purpose by utilizing the presented material. The equestrian world has pre

Möjligheten att beviljas uppehållstillstånd på grund av anknytning har sedan länge varit möjligt enligt det svenska regelverket. Systemets baksida är att den anhöriges uppehållstillstånd är beroende av anknytningspersonen varför en inlåsningseffekt kan uppstå vid våldsutsatthet. Som i ett försök att mildra reg-lernas negativa följder har lagstiftaren infört en skyddsregel som möjliggör att fortsatThe possibility of being granted a residence permit on the basis of affiliation has long been possible under Swedish legislation. The downside of the sys-tem is that the family member's residence permit is dependent on the person to which he/she are affiliated with, so a lock-in effect can arise in cases of vio-lence. In an attempt to mitigate the negative consequences of the regulation, the l