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Acinetobacter baumannii Clinical Isolates Resist Complement-Mediated Lysis by Inhibiting the Complement Cascade and Improperly Depositing MAC

Introduction: Acinetobacter baumannii is a gram-negative opportunistic bacterium that causes life-threatening infections in immunocompromised hosts. The complement system is a critical mechanism of innate immunity that protects the human body from bacterial infections. Complement activation leads to the deposition of the membrane attack complex (MAC), which can directly lyse gramnegative bacteria.

Nurse-led atrial fibrillation clinics in primary health care : a review of the evidence

Background: Atrial fibrillation (AF) is the most common arrhythmia worldwide and the majority of AF patients are treated in primary care. In order to minimize hospitalizations and visits to emergency departments, nurse-led care was introduced in secondary care and primary health care (PHC). However, even though nurse-led care was initiated in PHC almost a decade ago, and ESC guidelines recommended

Impact of formula protein quantity and source on infant metabolism : serum, urine, and fecal metabolomes of a randomized controlled study

Background: Human milk offers significant health benefits for infants; however, when not feasible, infant formula serves as an alternative. The higher protein content in infant formula is thought to contribute to the distinct metabolic profiles observed in formula-fed infants compared with those fed human milk. Objectives: This study investigates the impact of formula protein quantity and whey pro

Adverse prognosis gene expression patterns in metastatic castration-resistant prostate cancer

Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease. Several studies have identified transcriptional subtypes of mCRPC, but comprehensive analysis of prognostic gene expression pathways has been limited. Therefore, we aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression-based pathways with clinical out

Predicting Reduction Potentials of Blue Copper Proteins Using Quantum Mechanical Calculations

We have calculated redox potentials of 12 blue copper protein sites comparing 64 computational methods, systematically varying the quantum mechanics (QM) system size, dielectric constants, density functional, and basis sets. All methods were based on structures optimized with combined QM and molecular mechanics (QM/MM) approaches. The redox potentials were evaluated using 10 quality metrics. The b

Green infrastructure has weak conceptual links with efficient biodiversity conservation

To reverse biodiversity loss, creating resilient ecological networks has been promoted in policy and practice. However, we argue that emphasising networks within policy without clear conservation prioritisations may direct focus away from ecological processes important for population persistence. We studied the rationale for resilient ecological networks represented in a policy context, by reviewi

Real-world experiences of adult individuals or caregivers of children who received teplizumab treatment in stage 2 type 1 diabetes

Aims: This study surveyed individuals and caregivers of children who received teplizumab at stage 2 type 1 diabetes (T1D) to garner real-world experiences and their health outlook for the future following treatment with the first approved disease-modifying immune therapy for delaying the onset of Stage 3 T1D. Materials and Methods: This was a cross-sectional, observational, online survey (conducte

Self-reported sleep disturbances and its determinants in people 1 year or more after stroke : A cross-sectional study

Background: Survivors of stroke commonly report sleep disturbances. Studies of sleep disturbances after stroke are mostly performed in the acute phase. An increased knowledge of sleep disturbances and its determinants a longer time after stroke is needed to improve treatment and rehabilitation. Objective: To assess survivors of stroke more than 1 year after stroke onset and (1) investigate self-re

Information capacity of quantum communication under natural physical assumptions

The quantum prepare-and-measure scenario has been studied under various physical assumptions on the emitted states. Here, we first discuss how different assumptions are conceptually and formally related. We then identify one that can serve as a relaxation of all others, corresponding to a limitation on the one-shot accessible information of the state ensemble. This motivates us to study the optima

The Electric Slide Towards Net-Zero: Pinpointing the Conditions for Heavy-Duty Emission Reductions

The road freight sector’s significant contribution to greenhouse gas emissions necessitates emission mitigating strategies to meet climate targets, such as the Paris Agreement’s goal of 43% emission reduction. While Battery Electric Trucks (BETs) show great potential to reach these goals, their successful integration hinges on optimization and route planning. This thesis investigates the condition

Measuring Disconnection from Nature: Validation of the Nature Disconnectedness Scale and Its Psychological and Environmental Correlates

In order to solve planetary health, the human-nature relationship has to be understood in more detail. Therefore, the current study aimed to validate and assess construct, convergent, divergent, and predictive validity of the Nature Disconnectedness Scale. Using data from 312 participants in Sweden, confirmatory factor analyses found support for a structure consisting of three dimensions and eight

Evaluating the impact of an interactive prototype on user engagement and learning in technical product communication

This study investigates the effectiveness of an interactive module compared to an e-brochure designed to market a video analytics technology. The interactive module was developed using the same core content as the e-brochure, allowing for a direct comparison of format effects. The primary focus of the study is to evaluate how the interactive module impacts user engagement across cognitive, behavio

Modeling False Memories with Conceptual Spaces

The most well researched associative memory illusion (AMI) is the Deese–Roediger–McDermott (DRM) paradigm: a list learning task found to induce false memories though study lists with associated words. Typically, the study lists are composed of the 12—15 most frequent Kent-Rosanoff word-pair associations of a "critical lure". This thesis attempts a different approach to list generation.

Different conditions for reading aloud sessions. An investigation of the importance of the environment for attention and memory when reading aloud.

I det svenska samhället syns en nedåtgående trend när det gäller barn och ungas läs- och skrivförmåga. Därmed finns det ett värde i att utforska effekter av läsfrämjande initiativ. Den aktuella studien ämnar således att studera vilken betydelse miljön på kulturhuset Funnys Äventyr kan ha i relation till högläsning. Mer specifikt undersöks vilken betydelse miljön har för barns nivå av distraktion o

Reducing Cognitive Load in Sales Training: An Experimental Study on Self-Directed Learning

This thesis examines how insights from cognitive science can inform the design of self-study training materials to reduce cognitive load and enhance sales onboarding in complex technical domains. The study was conducted at a global company specializing in industrial sensor solutions, focusing on machine vision sales training. The study was conducted in three phases. First, a pre-study mapped the

Women Leaders in the Third Sector: Exploring Motivation, Self-Leadership Strategies and Gender Barriers in Estonia and Sweden

The third sector encompasses organisations that are highly value-driven and oriented toward social change, often addressing needs overlooked by governmental bodies. This thesis explores the leadership experiences of women in this sector, focusing on their motivations for attaining leadership roles, self-leadership strategies used, and whether they encounter gender-based barriers throughout their l

Who Am I Becoming? Identity Construction in Graduate Development Programs

This study investigates how early-career professionals construct their professional identities within the context of graduate development programs. As organizations increasingly rely on graduate development programs to attract and develop high-potential graduates, these programs have become an important talent development strategy for cultivating future leaders. Yet, despite the growing prevalence

Replicating or Evolving? Highlighting the Tension between Organizational Fit and Diversity in Recruitment Processes

In modern recruitment, organizations tend to face a persistent paradox: they must align candidates with existing cultural values while simultaneously promoting workforce diversity. This thesis investigates how HR professionals navigate the inherent tension between organizational fit and diversity within recruitment processes across multinational public and private organizations in Europe and South

Corporate Sustainability in Practice: A Case Study of Employee Perspectives on Strategy Implementation

This thesis explores how employees influence and experience Corporate Sustainability (CS) strategy implementation at Sony. Through interviews with twelve staff members across departments, it highlights misalignment between CS goals and daily roles, and the need for clearer guidance. Bottom-up initiatives offer promise but need institutional backing. The study recommends improved communication, tra

Sustainability and Profit in Fashion: Insights from Born-Sustainable SMEs in Brazil and Scandinavia

This thesis explores how born-sustainable small and medium-sized enterprises (SMEs) in the fashion industry can balance and improve the implementation of sustainability and profitability. It develops a cross-cultural analysis, comparing Brazil and Scandinavia (namely Sweden and Denmark). A constructionist framework is adopted in order to analyse culture, sustainability, and profitability with a su