Nucleoside analogues (NA) are prodrugs that are phosphorylated by deoxyribonucleoside kinases (dNKs) as the first step towards a compound toxic to the cell. During the last 20 years, research around dNKs has gone into new organisms other than mammals and viruses. Newly discovered dNKs have been tested as enzymes for suicide gene therapy. The tomato thymidine kinase 1 (ToTK1) is a dNK that has been

Objectives. To evaluate the agreement and performance of two tests for aPLs with regard to association with manifestations of the APS in patients with SLE.Methods. We investigated 712 SLE patients and 280 population controls. Cardiolipin and β(2) glycoprotein-I antibodies were measured with routine ELISA and a new automated method. Three positivity cut-offs (99%, 90% of controls and recommended cu

Objective. An extensive remodeling of the human cervical connective tissue occurs throughout pregnancy, with a decrease in the total concentration of collagen and proteoglycans. We hypothesized that the profound changes in proteoglycan production in the cervix would be seen in corresponding cervical fibroblasts as well. Methods. Cervical biopsies were obtained from five non-pregnant women, five wo

Heart period variability and heart rate were studied in 15 women and 15 men while they were viewing negatively (snakes/spiders), neutrally (scenic views), and positively (cats and kittens/puppies and dogs) valenced films. Time-frequency analyses of the heart period variability power spectrum in the high frequency region (0.12-0.4 Hz), reflecting respiratory sinus arrhythmia (RSA), were carried out

The printing of a manuscript of lectures in medieval archaeology by docent Rikard Holmberg: Kyrkobyggnad, kult and samhälle. Landskyrkan i Lunds forna ärkestift genom tiderna (Church building, cult and society. The country church in the former arch bishopric of Lund through time) from 1972-73

Kulturartikel om science fiction-författaren Arthur C Clarke med anledning av den aktuella romanen 3001 - The Final Odyssey.

When writing computer software one is often forced to balance the need for high run-time performance with high programmer productivity. By using a high-level language it is often possible to cut development times, but this typically comes at the cost of reduced run-time performance. Using a lower-level language, programs can be made very efficient but at the cost of increased development time. Re

INTRODUCTION: The use of EVAR for more complex aneurysm anatomy has become more widespread over the past decade. Fenestrated and branched stent grafts for the visceral and iliac segment show promising short- and midterm outcome and these procedures have become routine in many vascular centers. However, at present, such grafts are customized to the individual patient and planning and manufacturing

Anticipatory and predictive models are becoming very important features of robot systems. This thesis investigates some aspects of predictive modeling. Is prediction always a good thing? How important is it to anticipate what will happen in the future? Is it better to anticipate far into the future or to focus on the next few seconds? What are the requirements for predictive models? Predictive mod

BACKGROUND: Prognostic and treatment-predictive biomarkers in primary breast cancer are routinely analyzed in the primary tumor, whereas metastatic tumor cells in lymph node metastases are not characterized. The present study aimed to define the concordance between biomarkers in matched pairs of breast cancers and lymph node metastases and to relate their expression to clinical outcome. METHODS: P

Artikeln diskuterar den nyandliga terapin i det svenska samhället med egetcertifierat ledarskap och som vill sälja healing och självförverkligande.

A low phase noise CMOS LC quadrature VCO (QVCO) with a wide frequency range of 3.6-5.6 GHz, designed in a standard 0.18 /spl mu/m process for multi-standard front-ends, is presented. A significant advantage of the topology is the larger oscillation amplitude when compared to other conventional QVCO structures. The QVCO is compared to a double cross-coupled LC-tank differential oscillator, both in