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Introduction: Despite increasing recognition of pediatric acute-onset neuropsychiatric syndrome (PANS), its neuropsychological underpinnings remain limited, particularly in relation to obsessive-compulsive disorder (OCD) symptoms. PANS manifests abruptly with severe OCD and/or eating restrictions alongside concurrent neuropsychiatric symptoms, causing distress and functional impairment. This study
Enzymes are dynamic entities, and their conformational dynamics are intimately linked to their function and evolvability. In this context, protein tyrosine phosphatases (PTPs) are an excellent model system to probe the role of conformational dynamics in enzyme function and evolution. They are a genetically diverse family of enzymes, with a highly conserved catalytic domain, identical catalytic mec
Discovering topological quantum materials that combine nontrivial topology with large bandgaps and experimentally accessible signatures remains a central pursuit in condensed matter physics. We demonstrate, through first-principles calculations and tight-binding modeling, that pyrite-type osmium disulfide (OsS2) is a fragile topological insulator (FTI) characterized by an exceptionally large direc
While the concept of constituent power is central to democratic and radical political theory, its correlate—constituent rights—remains largely unexamined. This paper proposes a systematic theorization of constituent rights by revisiting Antonio Negri’s concept of constituent power through the lens of Baruch Spinoza’s principle of ius sive potentia (right or power). Although Negri draws extensively
Objectives: To describe the rationale, design and data collection procedures of the Swedish CArdioPulmonary bioImage Study (SCAPIS) re-examination, which, in its further scope, aims to quantify and explain the development of atherosclerosis, pathological cardiovascular ageing, longitudinal decline in lung function and the malignant transformation of pulmonary nodules among middle-aged Swedes in th
Fire has shaped terrestrial ecosystems for hundreds of millions of years. Human activities dramatically shift natural fire regimes, leading to adverse conservation impacts that are projected to increase in severity. Many animals appear ill-equipped to face these drastic changes, and they may be unable to adapt rapidly enough. In contrast, behavioural plasticity could offer a faster solution to ach
This paper uses a gender lens to analyse how bicycle-powered mobility futures can be articulated as counter-hegemonic alternatives to automobility. Drawing on interviews with transport professionals and activists, we interpret participants’ visions as efforts to rearticulate dominant understandings of everyday life, space, and time. Even though automobility continues to structure the horizon, we f
Avian haemosporidian parasites are globally widespread with a broad repertoire of hosts. When infected, the host can either reduce (resistance) and/or limit the severity of parasitaemia (tolerance). Oxidative stress plays a pivotal role in the host's resistance and tolerance, as well as its detrimental endpoints. The rationale behind this paradox lies in the dual role of reactive oxygen species (R
Streaming applications are often described using dataflow actor models with a fixed network structure, allowing for static analysis and efficient hardware implementation. However, this fixed structure hinders scalability and design space exploration. This article investigates a representative dataflow toolchain, the StreamBlock compiler for the CAL actor language, along with its Actor Machine (AM)
Chronic psychological stress is increasingly recognized as a major public health concern, contributing to cardiovascular disease, obesity, asthma, and impaired bone health. Although the mechanisms linking stress to skeletal dysregulation are well characterized in adults, pediatric studies remain limited. Longitudinal and mechanistic studies are needed to clarify how stress affects bone accrual dur
In Singapore, children’s education is often presented as “an overriding and all-consuming concern,” driven by intense competition for grades and school admissions (Waters, 2015: 290). However, the desire for academic excellence as a pathway to better lives is not as straightforward as it may seem. Drawing on ethnographic fieldwork with Singaporean families, this paper explores parents’ affective aIn Singapore, children’s education is often presented as “an overriding and all-consuming concern,” driven by intense competition for grades and school admissions (Waters, 2015: 290). However, the desire for academic excellence as a pathway to better lives is not as straightforward as it may seem. Drawing on ethnographic fieldwork with Singaporean families, this paper explores parents’ affective a
Background: Human immunodeficiency virus type 1 (HIV-1) is one of the fastest-evolving human pathogens. Understanding HIV-1 transmission, within-host adaptation, and evolutionary dynamics is pivotal for development of interventions and vaccines. HIV-1 infection is generally caused by a single transmitted founder virus (TFV), and TFV sequences are typically obtained using single genome amplificatio
Aim: The aim of this study was to describe the routines for handling mother's own milk and donor human milk in Swedish neonatal care units related to national guidelines. Methods: A web-based survey of 24 of 38 neonatal units and 19 of 28 human milk banks in Sweden. Results: Despite national guidelines, breast milk handling varied widely. All units offered lactation support and free breast pumps d
Background: The study of emotion regulation (ER) has gained traction in forensic psychological and psychiatric research as a correlate of antisocial and aggressive behavior as well as for its relevance to psychopathology. However, conceptual and definitional ambiguity persists. Methods: This pre-registered systematic review aimed to investigate how ER is conceptualized and measured in forensic pop
Second primary malignancies (SPMs) increasingly affect mantle cell lymphoma (MCL) survivors. In nationwide Danish and Swedish cohorts (2000–2020), we evaluated overall survival among MCL patients with SPMs versus matched non-lymphoma individuals with comparable malignancies and MCL patients without SPMs, respectively. Of 3094 MCL survivors, 19% in Denmark and 15% in Sweden developed an SPM, with a
Aims. We investigate the formation and evolutionary trajectory of the Milky Way’s inner and outer galactic regions using stars from open clusters in the Gaia-ESO OC survey. Methods. Using numerical simulations from Chempy, we leveraged Markov chain Monte Carlo sampling techniques to derive galactic evolutionary parameters for each open cluster by fitting measured abundances of elements C, N, O, Mg
Psychological distress, including depression, anxiety, and stress, requires time-efficient assessment tools suited for digital and momentary settings. The Screening Tool for Psychological Distress (STOP-D) is a five-item scale developed for brief mental health screening, but it has not yet been validated in Swedish. This study aimed to evaluate the psychometric properties and diagnostic accuracy o
Effective medical education relies on clearly defined learning objectives that foster deep and meaningful learning. This article presents a consensus-driven proposal for national learning objectives in dermatology and venereology within Sweden’s new medical programme qualifying for licensure. The primary aim is to harmonize educational standards across all medical faculties and to establish a comm
