Filtyp
Bergh S, Gabery S, Tonetto S, Kirik D, Petersén Å and Cheong RY. Neuropathology and Applied Neurobiology. 2023;49(2):e12891. doi:10.1111/nan.12891 [published correction appears in Neuropathol Appl Neurobiol. 2023 Jun;49(3):e12905]. Abstract Background: Early non-motor features including anxiety, depression and altered social cognition are present in Huntington's disease (HD). The underlying neurob
In May 2022, Karin Dalene Skarping started her PhD studies in TNU supervised by Prof. Åsa Petersén. The overall aim of the PhD project is to study genetic mechanisms that may modify the disease course and pathology of Huntington disease. One of her current research projects is aimed to examine associations between germline pathogenic variants in mismatch-repair (MMR) genes and CAG-repeats in HTT,
https://www.huntington-research.lu.se/team/karin-dalene-skarping-phd-student - 2025-10-13
Sofia Hult Lundh1, Nathalie Nilsson1, Rana Soylu1, Deniz Kirik2 and Åsa Petersén1.1Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund SE-221 84, Sweden.2Brain Repair and Imaging in Neural Systems (BRAINS) Unit, Department of Experimental Medical Science, Lund University, Lund SE-221 84, Sweden.Human Molecular Genetics 22: 3485-3497 (2013)A
Linda Holmquist Mengelbier is a paediatric cancer researcher who now, in parallel to her cancer effort, has started to work with the neurodegenerative disorders Huntington disease and ALS. Her focus in the cancer field has been on the embryonal pediatric solid tumors neuroblastoma and Wilms tumor. Neuroblastoma is a sympathetic nervous system tumor derived from the neural crest, whereas Wilms tumo
https://www.huntington-research.lu.se/team/linda-holmquist-mengelbier-phd - 2025-10-13
Soylu-Kucharz R, Adlesic N, Davidsson M, Björklund T, Björkqvist M and Petersén Å. bioRxiv 2023.03.04.530949; First published March 4, 2023, https://doi.org/10.1101/2023.03.04.530949 Abstract Huntington’s disease is a fatal neurodegenerative disorder caused by an expanded CAG triplet repeat in the huntingtin (HTT) gene. Previous research focused on neuropathology in the striatum and its associatio
Dalene Skarping K, Arning L, Petersén Å, Nguyen HP and Gebre-Medhin S.Sci Rep. 2024;14(1):4300. Published 2024 Feb 21. doi:10.1038/s41598-024-54277-5AbstractDNA mismatch repair (MMR) is thought to contribute to the onset and progression of Huntington disease (HD) by promoting somatic expansion of the pathogenic CAG nucleotide repeat in the huntingtin gene (HTT). Here we have studied constitutional
Lilja Andersson P, Juth N, Petersén Å, Graff C and Edberg AE.Lund University, Sweden.Nursing Ethics 20: 189-199 (2013)AbstractThe aim of this study was to describe the experiences of undergoing a presymptomatic genetic test for the hereditary and fatal Huntington’s disease, using a case study approach. The study was based on 18 interviews with a young woman and her husband from the decision to und
https://www.huntington-research.lu.se/ethical-aspects-undergoing-predictive-genetic-testing-huntingtons-disease - 2025-10-13
In 2024, Jennifer moved from Sydney, Australia to Lund, Sweden to start her PhD studies at the TNU, supervised by Pof. Åsa Petersén. In utilizing novel AAV-vectors and crossbreeding of animal models, Jennifer’s project aims to elucidate the specific hypothalamic circuitries important for the control of metabolism and emotion, with relevance to Huntington’s Disease, Amyotrophic Lateral Sclerosis an
https://www.huntington-research.lu.se/team/jennifer-oraha-phd-student - 2025-10-13
Lundh SH, Soylu R and Petersén Å.Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.PLoS ONE 7(12): e51168 (2012).AbstractMetabolic and psychiatric disturbances occur early on in the clinical manifestation of Huntington’s disease (HD), a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (HTT) gene. Hypot
Hagen N, Lundin S, O'Dell T and Petersén Å.Culture Unbound 4: 537-557 (2012)AbstractModernity has meant a cultural and social differentiation within the western socie- ty, which, according to Jürgen Habermas’ theory on communication, can be seen as a division between different forms of actions that takes place in different realms of the society. By combining Habermas’ notions of lifeworld and sys
https://www.huntington-research.lu.se/better-or-worse-lifeworld-system-and-family-caregiving-chronic-genetic-disease - 2025-10-13
Bergh S, Casadei N, Gabery S, Simonsson O, Duarte JMN, Kirik D, Nguyen HP and Petersén Å.Acta Neuropathologica Communications. 2025;13(1):119. Published 2025 May 27. doi:10.1186/s40478-025-02018-8AbstractTAR DNA-binding protein 43 (TDP-43) pathology is linked to the neurodegenerative disorders amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Huntington disease (HD). Dysregul
Li X, Li S, Li X-J, Nguyen HP, Petersen Å and Pouladi MA.Journal of Huntington’s Disease. 2025;14(3):270-278. doi: 10.1177/18796397251358017. AbstractHuntington's disease (HD) is a fatal neurodegenerative disorder characterized by progressive motor, cognitive, and psychiatric symptoms. Research efforts to understand and treat the disease have historically focused on neuronal pathology, but growing
https://www.huntington-research.lu.se/role-oligodendroglial-dysfunction-huntingtons-disease - 2025-10-13
Pouladi MA and Petersen A.Journal of Huntington’s Disease. 2025;14(3):212-213. doi: 10.1177/18796397251358289.No abstract available.Full text article - on Sage Journal's webpage (opens in a new window)
https://www.huntington-research.lu.se/special-issue-glia-and-non-neuronal-cells-huntingtons-disease - 2025-10-13
Gabery S, Sajjad MU, Hult S, Soylu R, Kirik D and Petersén Å.Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, Lund, Sweden.Brain Repair and Imaging in Neural Systems (B.R.A.I.N.S.) Unit, Department of Experimental Medical Sciences, Lund University, Lund, Sweden.European Journal of Neuroscience 36(6):2789-800 (2012)AbstractHuntington's diseas
A new paper from TNU has been published, shedding light on the key role of TDP-43 in the hypothalamus in models of neurodegenerative disorders, including amyotrophic lateral sclerosis, frontotemporal dementia, and Huntington's disease. The paper was published with international collaborators in Acta Neuropathologica Communications on May 27, 2025Full text article on BMC:s webpage (opens in a new w
https://www.huntington-research.lu.se/paper-tdp-43-key-roll-hypothalamus - 2025-10-13
Petersen Å and Gabery S.Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, Lund, Sweden.Journal of Huntington's disease 1: 13-24 (2012)AbstractHuntington’s disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Today, the clinical diagnosis of the disease requires unequivocal signs of typical moto
https://www.huntington-research.lu.se/hypothalamic-and-limbic-system-changes-huntingtons-disease - 2025-10-13
Dupuis L1, 2, 3, Petersen A4, Weydt P31 Inserm U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, 67085Strasbourg, France2 Université de Strasbourg, Faculté de Médecine, UMRS692, 67085Strasbourg, France3 Department of Neurology, Ulm University, 89081 Ulm, Germany4 Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, 22184Lu
https://www.huntington-research.lu.se/progranulin-bridges-energy-homeostasis-and-fronto-temporal-dementia - 2025-10-13
Hult S*, Soylu R*, Björklund T, Belgardt B F, Mauer J, Brüning J C, Kirik D and Petersén Å.Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, Lund 22184, Sweden.Cell Metabolism 13: 428-439 (2011) *equal contributionAbstractIn Huntington's disease (HD), the mutant huntingtin protein is ubiquitously expressed. The disease was considered to be li
Piguet O, Petersén A, Yin Ka Lam B, Gabery S, Murphy K, Hodges JR and Halliday GM.Neuroscience Research Australia, Sydney, Australia.Annals of Neurology 69: 312-319 (2011)AbstractOBJECTIVE: Behavioral-variant frontotemporal dementia (bvFTD) is a progressive neurodegenerative brain disorder, clinically characterized by changes in cognition, personality, and behavior. Marked disturbances in eating b
https://www.huntington-research.lu.se/eating-and-hypothalamus-changes-behavioral-variant-frontotemporal-dementia - 2025-10-13
2025Pouladi MA and Petersen A.Special issue: Glia and non-neuronal cells in Huntington’s disease.Journal of Huntington’s Disease. 2025;14(3):212-213. doi.org/10.1177/18796397251358289Li X, Li S, Li X-J, Nguyen HP, Petersen Å and Pouladi MA.The role of oligodendroglial dysfunction in Huntington's disease.Journal of Huntington’s Disease. 2025;14(3):270-278. doi: 10.1177/18796397251358017. Bergh S, C
https://www.huntington-research.lu.se/publications - 2025-10-13
