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BACKGROUND: Sepsis-induced coagulopathy (SIC) is a scoring system developed for early detection of coagulopathy in sepsis and selection of patients for interventional studies. Our aim was to define the prevalence of SIC in a critically ill population and investigate if SIC at intensive care unit (ICU) admission is associated with morbidity and mortality.METHODS: Patients admitted with septic shock

PURPOSE: Early administration of beta-lactam antibiotics is a crucial part in the treatment of sepsis and septic shock. Beta-lactams demonstrate time-dependent killing and therefore it is important to optimize the time above the minimal inhibitory concentration (MIC). An extra dose is recommended in threatening/suspected/confirmed septic shock. This study aimed to examine whether patients with sus

OBJECTIVES: This study aims to compare the performance on motor and cognitive functions of adult patients with attention deficit hyperactivity disorder (ADHD) with or without psychostimulant medication, and controls. A secondary objective is to investigate differences on test performance across varying levels of disorder severity.METHODS: We included patients with unmedicated ADHD (n=52), patients

The Open and Reproducible Musculoskeletal Imaging Research community is a scientific community dedicated to promoting openness and reproducibility in musculoskeletal imaging, image processing, and computational modeling. In this perspective paper, we outline the motivations for conducting transparent research and provide practical guidelines for implementing it. We start by defining open and repro

Background: The presence of cancer in pelvic lymph nodes removed during radical surgery for muscle-invasive bladder cancer (MIBC) is a key determinant of patient outcome. It would be beneficial to predict node status preoperatively to tailor the use of neoadjuvant chemotherapy and extent of lymph node dissection. Of 12 published node status predictors based on tumor RNA expression signatures, non

Kan man leva på en ödegård? Uppenbarligen har man inte kunnat det eftersom flera medeltida gårdar efter pesten och den medeltida agrarkrisen förblev öde. Svaret på frågan är avhängigt inte bara arealer, klimat och jordar utan i lika stor utsträckning sociala förhållanden och odlingssystem. Den kan alltså omformuleras till: På vilka villkor kan en given yta tjäna som underlag för ett hushåll?Detta

In addition to the family context, persons in the neighborhood and community are important for individual life course, socioeconomic and demographic outcomes such as education, career and family transitions. This paper aims to study how neighborhood conditions in childhood influence fertility outcomes in adulthood. Theories focusing on motivation, aspirations and attitudes or peer influence generaIn addition to the family context, persons in the neighborhood and community are important for individual life course, socioeconomic and demographic outcomes such as education, career and family transitions. This paper aims to study how neighborhood conditions in childhood influence fertility outcomes in adulthood. Theories focusing on motivation, aspirations and attitudes or peer influence genera

A graphics processing system that is operable to perform ray tracing using micromaps is disclosed. A tree representation of a micromap is generated, and when it is desired to determine whether and/or how a ray interacts with a sub-region of a primitive, the tree representation of the micromap is traversed to determine a property value for the sub-region of the primitive.

This qualitative study analyses exaggeration in natural conversation from a dialogic perspective using data from the London–Lund Corpus 2 (LLC–2). We define exaggeration as an extreme degree on a scale, e.g., my bag weighs a ton. degree is central to our definition of exaggeration, which involves scaling a gradable property up, or down, to a level that comes across as counterfactual or inappropria

Determining the drivers of intraspecific variation in cognitive performance is crucial for understanding how cognition evolves, but experimental studies are scarce. Several correlational studies have supported the hypothesis that living in larger groups enhances cognitive performance. However, empirical explanations of whether and how living in large groups causally affects individual cognitive pe