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The bone marrow microenvironment contains cellular niches that maintain the pool of hematopoietic stem and progenitor cells and support hematopoietic maturation. Malignant hematopoietic cells also co-opt normal cellular interactions to promote their own growth and evade therapy. In vivo systems used to study human hematopoiesis have been developed through transplantation into immunodeficient mouse
The paper reports an interview-based study that considers market driving and market-driven activities within the disaggregated components of the business model. The empirical study is of IKEA in China over a 10 year period. Market orientation is considered as a position on a continuum rather than as binary positions. The components of the business model are developed from the Osterwalder and Pigne
In this study, the thermal and hydraulic performances of six different printed circuit heat exchanger (PCHE) configurations with supercritical liquefied natural gas as the working fluid are studied by a numerical method. Firstly, the thermal and hydraulic performances of the PCHE with airfoil fins are investigated at different operating pressures, which indicate that the PCHE with airfoil fins has
We are very happy that someone has finally tried to make sense of rationalization. But we are worried about the representational structure assumed by Cushman, particularly the "boxology" belief-desire model depicting the rational planner, and it seems to us he fails to accommodate many of the interpersonal aspects of representational exchange.
Objectives and methods: We conducted a population-based study including 19 303 individuals diagnosed with MGUS in Sweden from 1985 to 2013, with the aim to determine whether a prior history of autoimmune disease, a well-described risk factor for MGUS is a risk factor for progression of MGUS to multiple myeloma (MM) or lymphoproliferative diseases (LPs). Using the nationwide Swedish Patient registr
We study shrinking target problems and the set of eventually always hitting points. These are the points whose first n iterates will never have empty intersection with the nth target for sufficiently large n. We derive necessary and sufficient conditions on the shrinking rate of the targets for to be of full or zero measure especially for some interval maps including the doubling map, some quadrat
The concept of critical performativity–efforts to make critical research more relevant for groups outside academia and develop and communicate action-relevant critical insights with some potential effect–has received considerable interest. Much of this has focused on debates about the core concept and principles. This paper argues for the need to “do”–more than talk about–critical performativity a
Deterministic Lateral Displacement (DLD) is a passive technique employed for particles sorting. We recently introduced a DLD device composed of arrayed three-dimensional metal-covered pillars that can be used to locally apply an electric field. With our system we can exploit the dielectrophoretic (DEP) effect to exert forces on the bioparticles to be sorted, thus dynamically tuning the critical si
Satellite images are primary data in weather prediction modeling. Deep learning-based approach, a viable candidate for automatic image processing, requires large sets of annotated data with diverse characteristics for training purposes. Accuracy of weather prediction improves with data having a relatively dense temporal resolution. We have employed interpolation and data augmentation techniques fo
After a long period of decline, the number of forest birds has increased in Sweden in recent decades. Whether this trend is due to an increase in forested area, forest quality, climate change, or a combination of these factors, remains unclear. Here, we compared forest bird data from a local winter point count route around Storuman in Swedish Lapland between 1986 and 2017, with the development of
It is known for more than 100 years that the intestinal microbes are important for the host's health and the last decade this is being intensely studied with a focus on the mechanistic aspects. Among the fundamental functions of the intestinal microbiome are the priming of the immune system, the production of essential vitamins and the energy harvest from foods. By now, several dozens of diseases,
Congenital stationary night blindness (CSNB) is a group of rare, mainly stationary disorders of the retina, resulting from dysfunction of several specific and essential visual processing mechanisms. The inheritance is often recessive and as such, CSNB may be more common among populations with a high degree of consanguinity. Here, we present a topic update and a review of the clinical and molecular
Introduction: In some European countries, discharge the day after planned cesarean section has become an accepted procedure. However, little is known about the patients’ perception of early discharge. The aim of this study was to compare early discharge with standard care in relation to parental sense of security. Further, we evaluated postoperative pain, mobilization, and readmission. Material an
Theater shows routinely turn over actors in lead roles. Otherwise, the show stays the same, including the director, the script, other actors and, the physical theater environment. Even the lines performed do not change the set. Therefore, the theater provides a unique laboratory for assessing the value of human capital to an enterprise, a question that has been studied in other contexts, including
Optical trapping and assembling dynamics of polystyrene microparticles (MPs) of 1 μm in diameter are studied at its solution-air surface using a widefield microscope. Upon switching on the intense 1064 nm laser, the MPs are gathered, forming a single concentric circle (CC)-like assembly larger than the focus. It consists of a few tens of MPs, and the central part of the assembly shows structural c
In this paper we consider the case of planar motion, where a mobile platform equipped with two cameras moves freely on a planar surface. The cameras are assumed to be directed towards the floor, as well as being connected by a rigid body motion, which constrains the relative motion of the cameras and introduces new geometric constraints. In the existing literature, there are several algorithms ava
The thermal state of a glow discharge with intermediate current in flowing atmospheric air is investigated by a combination of Rayleigh scattering thermometry imaging and numerical simulation. Results from the simulation indicate that during the initial breakdown the local translational temperature can reach a huge value (e.g. 6000 K) but decreases quickly due to strong heat transfer to the surrou
This paper studies the relation between persuasive argumentation and the speaker’s epistemic attitude. Dung-style abstract argumentation and dynamic epistemic logic provide the necessary tools to characterize the notion of persuasion. Within abstract argumentation, persuasive argumentation has been previously studied from a game-theoretic perspective. These approaches are blind to the fact that, i
During the past few decades, intensive research has been focused on the application of biological photosynthetic processes for "green" electrical power generation. In this contribution, we consider different possible photobiocatalysts, such as isolated photosystems, thylakoid membranes (TMs), and whole photosynthetic organisms suitable for building bioelectrochemical systems for light energy conve
Typing of amyloidosis by mass spectrometry (MS) based proteomic analysis contribute to the diagnosis of amyloidosis. For MS analysis, laser microdissection (LMD) is used for amyloid specific sampling. This study aimed to establish a method for selectively extracting amyloids from formalin-fixed, paraffin-embedded (FFPE) specimens by organic solvent instead of LMD. The extracts using dimethyl sulfo
