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Neurodegenerative diseases are the most common cause of dementia. Although their underlying molecular pathologies have been identified, there is substantial heterogeneity in the patterns of progressive brain alterations across and within these diseases. Recent advances in neuroimaging methods have revealed that pathological proteins accumulate along specific macroscale brain networks, implicating

Summary: A large international meta-analysis using primary data from 64 cohorts has quantified the increased risk of fracture associated with a previous history of fracture for future use in FRAX. Introduction: The aim of this study was to quantify the fracture risk associated with a prior fracture on an international basis and to explore the relationship of this risk with age, sex, time since bas

The ATLAS detector at the Large Hadron Collider has been used to measure jet substructure modification and suppression in Pb+Pb collisions at a nucleon–nucleon center-of-mass energy √sNN = 5.02 TeV in comparison with proton–proton (pp) collisions at √s = 5.02 TeV. The Pb+Pb data, collected in 2018, have an integrated luminosity of 1.72 nb−1, while the ppdata, collected in 2017, have an integrated

Even among the most irradiated gas giants, so-called ultra-hot Jupiters, KELT-9b stands out as the hottest planet thus far discovered with a dayside temperature of over 4500 K. At these extreme irradiation levels, we expect an increase in heat redistribution efficiency and a low Bond albedo owed to an extended atmosphere with molecular hydrogen dissociation occurring on the planetary dayside. We p

Background: Most strokes and cardiovascular diseases (CVDs) are potentially preventable if their risk factors are identified and well controlled. Digital platforms, such as the PreventS-MD web app (PreventS-MD) may aid health care professionals (HCPs) in assessing and managing risk factors and promoting lifestyle changes for their patients. Methods: This is a mixed-methods cross-sectional two-phas

During the past decade, cognitive neuroscience has been calling for population diversity to address the challenge of validity and generalizability, ushering in a new era of population neuroscience. The developing Chinese Color Nest Project (devCCNP, 2013–2022), the first ten-year stage of the lifespan CCNP (2013–2032), is a two-stages project focusing on brain-mind development. The project aims to

This essay recalls the concept of ‘magical thinking’ and provides a scooping description of its utilitarian value. ‘Magical thinking’ is a classic notion in cognitive anthropology, and it is seen as a utilitarian cognitive pattern that provides a platform to practice magico-religious beliefs and to build confidence in the operational efficacy of these belief practices. In cognitive psychology, mag

In 1617, after seven years of war between Sweden and Russia and talks facilitated by English and Dutch diplomats, the peace treaty of Stolbovo was signed. This important but little-studied document was to form the basis for relationships between Sweden and Russia for the next one hundred years, before it was replaced by the Peace of Nystad in 1721, and it had a huge influence on the lives of the p

Self-oscillation—the periodic change of a system under a non-periodic stimulus—is vital for creating low-maintenance autonomous devices in soft robotics technologies. Soft composites of macroscopic dimensions are often doped with plasmonic nanoparticles to enhance energy dissipation and generate periodic response. However, while it is still unknown whether a dispersion of photonic nanocrystals may

The Kalabagh strike–slip fault, which is characterized by right-lateral movement, is part of the northwestern Himalayan foreland fold and thrust belt in Pakistan. This structure marks the western and eastern terminations of the Salt Range and Surghar Ranges, respectively. No significant (>M6) earthquakes have been reported along the Kalabagh Fault in recent decades. Here, we take advantage of spac

In this work two-color laser-induced fluorescence (2c-LIF) is applied to calibrate and measure the temperature in a micrometric monodisperse ethanol droplet chain. A dye mixture of fluorescein disodium (FL) and sulforhodamine 101 (SRh) is used, in order to form a sensitive signal ratio of one temperature dependent and one independent fluorophore. Spectral and planar fluorescence detection via a fi

This article describes the mainstream global debates in the field of (anti-) corruption, discusses the main challengesto understanding and combating corruption, as well as introduces an interdisciplinary socio-legal perspective to the study of (anti-) corruption. Based on these global experiences, the article provides recommendations for developing an educational program in the field of (anti-) co

Academic debates on law and society relations in authoritarian regimes continue to revolve around issues of the dysfunctional legal system, corruption and informality, clientelistic legal culture, and how the authoritarian regimes in this region deploy law as a means for suppressing dissent. However, in this article, we argue that the legal landscape of authoritarian regimes should not be viewed f

Background The efficacy of the interception and purification mechanism for low-dose toxic contaminants in riverbeds, which serve as a link between surface water and groundwater, is of paramount importance in ensuring groundwater safety, particularly considering the replenishment of reclaimed water. The specific objective of this work is to identify the variation of interception efficiency and tran

We present a deep learning method for accurately localizing the center of a single corneal reflection (CR) in an eye image. Unlike previous approaches, we use a convolutional neural network (CNN) that was trained solely using synthetic data. Using only synthetic data has the benefit of completely sidestepping the time-consuming process of manual annotation that is required for supervised training

Considering recent developments in the energy sector, further reduction of electricity cost and flattening of the electric power demand curve are needed. We have focused on an autonomous electric heater control system that can easily be implemented in existing buildings without strict comfort requirements. Examples are winter heating of warehouses and vacation homes, and heat drying of buildings u