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The precise separation of nanoscale particles has proven challenging due to diffusion and the need to use nanoscale devices. We show the separation of particles in the 100 nm size range in Deterministic Lateral Displacement (DLD) devices with feature sizes in the 10 µm size range. We achieve this using Dielectrophoretic (DEP) forces, generated between the metal coated posts that act as active elec
Freely grazing horses are at risk of infection by parasites such as Parascaris equorum (roundworm), Strongylus spp. (large bloodworms), Cyathostomes (small bloodworms), and Anoplochephala perfoliata (tapeworms). Mixed infections are common and diagnosis is based on demonstrations of eggs in feces followed by identification of larvae after fecal culture. Drug resistance is a growing problem, not le
A variety of pathogenic bacteria can infect humans and the increase in bacteria resistant to common antibiotics is a large threat to human health worldwide. This work presents a method, based on optical DNA mapping (ODM) in nanofluidic channels, that can detect the type of bacterial present in a sample by matching the obtained maps of large DNA molecules to a database of fully assembled bacterial
We present a method to rapidly fabricate a large number of thermoplastic microfluidic systems where horizontal microchannels are separated by a porous membrane for modelling biological barriers. We optimize and combine solvent bonding, milling and laser cutting to fabricate in excess of 100 devices in two days. The optimized protocol relies on a commercial solvent blend, retention grooves for solv
INTRODUCTION: Renal ETK/BMX activity is reduced in preeclampsia. Systemic RAS has been studied in preeclampsia; the renal RAS has not. None of the proteins in either pathway have previously been located in renal tissue from human pregnancy.OBJECTIVES: To determine renal expression and distribution of proteins involved in the ETK/BMX and RAS pathways in normal and preeclamptic pregnancy.METHODS: Li
INTRODUCTION: Vascular endothelial growth factors (VEGF's) are essential to angiogenesis and play a central role in the pathophysiology of preeclampsia. Specifically, antagonists of VEGFR2 cause a preeclampsia-like syndrome, in humans and rats[1]. ETK/BMX is a receptor tyrosine kinase (RTK) which induces VEGF expression and forms a complex with VEGFR2, whereby VEGF and TNF can induce a reciprocal
Fluid anomalies were often considered as possible precursors before earthquakes. However, fluid properties at the surface can change for a variety of reasons, including environmental changes near the surface, the response of the superficial fluid system to loads associated with the mechanical nucleation of earthquake fractures, or as a result of transients in fluid flow from the depths. A key prob
BACKGROUND: Intraoperative nerve monitoring (IONM) of the recurrent laryngeal nerve (RLN) predicts the risk of vocal cord palsy (VCP). IONM can be used to adapt the surgical strategy in order to prevent bilateral VCP and associated morbidity. Controversial results have been reported in the literature for the effect of IONM on rates of VCP, and large multicentre studies are required for elucidation
The characterization of exoplanets and their birth protoplanetary disks has enormously advanced in the last decade. Benefitting from that, our global understanding of the planet formation processes has been substantially improved. In this review, we first summarize the cutting-edge states of the exoplanet and disk observations. We further present a comprehensive panoptic view of modern core accret
The Analog to Digital (A/D) Converters (ADC) are vital components in high-performance radio devices. In the receiver end, the signal received by the analog front-end can not be directly analyzed by the digital core, thus requiring high-performance ADC circuits acting as bridges connecting the analog and digital domain. These circuits are integrated into Complementary Metal-Oxide-Semiconductor (CMO
Ecosystem models commonly use stable‐state assumptions to predict responses of soil microbial functions to environmental change. However, past climatic conditions can shape microbial functional responses resulting in a ‘legacy effect’. For instance, exposure to drier conditions in the field may shape how soil microbial communities respond to subsequent drought and drying and rewetting (DRW) ev
This paper presents a 10-bit SAR ADC with a sampling rate of 200 MS/s. To reduce area and power consumption, the ADC adopts a split-capacitor DAC, where the gain error is estimated and subsequently removed by means of a PRBS signal injected into the DAC and detected at the ADC output. The ADC has been designed and fabricated in a 22nm FD-SOI CMOS process, and achieves an SNDR of 48.7 dB and an SFD
This paper analyzes the bit conversion errors in high speed SAR ADCs and proposes a design method to minimize their impact on the ADC performance. By removing the SR latch from the output stage of the differential comparator, while using only one comparator output to generate the differential signals for the internal capacitive DAC, sparkle-code errors are avoided, and conversion errors from a pre
This thesis consists of four papers that broadly concerns two dierent topics. The rsttopic is so-called barycentric Markov processes. By a barycentric Markov process wemean a process that consists of a point/particle system evolving in (discrete) time,whose evolution depends in some way on the mean value of the current points in thesystem. In common for the three rst papers which are on this topicThis thesis consists of four papers that broadly concerns two dierent topics. The rsttopic is so-called barycentric Markov processes. By a barycentric Markov process wemean a process that consists of a point/particle system evolving in (discrete) time,whose evolution depends in some way on the mean value of the current points in thesystem. In common for the three rst papers which are on this topic
Although there has been a long tradition of public space-related land speculation and development, the recent success of the High Line in New York has highlighted the transformative effect carefully designed and curated public spaces can have on the local economy. By prioritising exchange value over use value, governments and developers are exploiting the production of public spaces as a means for
The production of K∗(892)0 and φ(1020) in pp collisions at s=8 TeV was measured by using Run 1 data collected by the ALICE collaboration at the CERN Large Hadron Collider (LHC). The pT-differential yields d2N/dydpT in the range 0
