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Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindi
Compulsory school can appear to be uniform because it is common. Its commonness has however more to do with compulsory school attendance than with the fact that all the pupils utilizes education of equal value. Beyond social differences compulsory school creates differences among the pupils just because they are kept in school. In this article three reasons for beeing in school are identified: co
Bone morphogenetic protein-2 (BMP2) plays a key role in bone formation and maintenance. Studies of polymorphisms within the gene in relation to bone mineral density (BMD) and fracture have been inconsistent. Our aim was to investigate associations between polymorphisms in the BMP2 gene and bone mass, fracture, and quantitative ultrasound (QUS) measures at different stages of skeletal development.
It is proved that existence of a density function is both necessary and sufficient for almost global stability in a nonlinear system.
BACKGROUND: Reduced lung function has been associated with increased rates of myocardial infarction. Whether the occurrence and prognostic significance of ventricular arrhythmia is related to lung function is largely unknown. METHODS AND RESULTS: We performed a population-based study of 68-year-old men without a history of stroke or myocardial infarction; 402 men participated. Mortality and corona
In the present study we have evaluated the knowledge, attitudes and intention to act in relation to HIV/AIDS related issues among Swedish students aged 15–18 years. An intervention group (n = 368) and a comparison group (n = 180) were followed for 2 years between 1989 and 1991. The teachers of the intervention group were obliged to specifically give a continuous and in-depth education while the co
TRIM22 (Staf50) is an interferon (IFN)-inducible protein with unknown function. Recently, we identified TRIM22 as a novel p53 target gene and showed that overexpression of TRIM22 inhibits the clonogenic growth of monoblastic U937 cells. Moreover, expression of TRIM22 is high in lymphoid tissue, and levels decrease during T lymphocyte activation with CD3/CD2/CD28, suggesting that TRIM22 could exert
1. We and others have shown that extracellular ATP (adenosine triphosphate), released from sympathetic nerves and platelets, stimulates growth of vascular smooth muscle cells (SMC). To study the importance of tyrosine kinases for ATP-mediated proliferation in vascular smooth muscle cells we used tyrphostins, a recently developed group of highly specific inhibitors of tyrosine kinases. 2. ATP induc
Process development, optimisation and robustness analysis for chromatography separations are often entirely based on experimental work and generic knowledge. The present study proposes a method of gaining process knowledge and assisting in the robustness analysis and optimisation of a hydrophobic interaction chromatography step using a model-based approach. Factorial experimental design is common
A set $C$ in a topological vector space is said to be weakly convex if for any $x,y$ in $C$ there exists $p$ in $(0,1)$ such that $(1-p)x+py\in C$. If the same holds with $p$ independent of $x,y$, then $C$ is said to be $p$-convex. Some basic results are established for such sets, for instance: any weakly convex closed set is convex.
Leukocyte recruitment in the liver includes a two-step procedure in which selectin-dependent leukocyte rolling is a prerequisite for subsequent CD18-dependent leukocyte firm adhesion in postsinusoidal venules. However, the roles of the individual selectins in leukocyte rolling and adhesion, hepatocellular injury, and apoptosis remain elusive. Therefore, we examined the pathophysiological role of P
Popular Abstract in Swedish Hjärnan är ett energikrävande organ och förbrukar ca 20% av blodets syre trots att den bara utgör 1-2% av kroppsvikten. Mitokondrien är den del av cellen där syre och näringsämnen förbränns till koldioxid och vatten, och mitokondrien kallas ofta för cellens kraftstation. Denna process, den så kallade cellandningen, är kopplad till produktion av den energirika molekylen There is currently no clinically available drug with neuroprotective properties to limit the evolving cell death following e.g. stroke or traumatic brain injury. The mitochondrial permeability transition (mPT) is a potential pathological mechanism causing cell death in the CNS. As the name implies, the mPT is defined by a sudden increase in permeability of the inner mitochondrial membrane, whose n
Det fins en önskan om fullständigt automatiserade nedströmsprocesser i framställandet av proteiner för läkemedelsbruk. En del av nedströmsprocessen är preparativ kromatografi. En god separation mellan produkt och andra proteiner, samt god produktivitet, är av intresse. På grund att kromatografisk separation ofta körs satsvis så skulle en iterative learning controller (ILC) vara ett bra val för attThere is a desire for a fully automated downstream process in pharmaceutical protein production. One part of the downstreaming process is preparative chromatography. A good separation between the product and other proteins, as well as good productivity, are desired. Due to the batch nature of chromatographic separation, an iterative learning controller (ILC) could be a suitable choice for achievin
Sammanfattning Jordens befolkning förväntas öka de kommande årtiondena. Detta kan skapa osäkerhet kring livsmedelsförsörjning och kräver en mer produktiv livsmedelssektor samt metoder för att bedöma tillgång på livsmedel i förhållande till efterfrågan. Utvecklandet av lågkostnadsmetoder för övervakning av grödor kan stödja en hållbar intensifiering av jordbruket och tillhandahålla användbar inforAbstract The population of earth is projected to increase the coming decades. This can pose problems of food security and demands a more productive food sector as well as methods of assessing food productivity in relation to demand. Crop monitoring with remote sensing can guide precision farming used for sustainable intensification of agriculture, as well as contribute to yield forecasting models
