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The Warburg effect, which describes the fermentation of glucose to lactate even in the presence of oxygen, is ubiquitous in proliferative mammalian cells, including cancer cells, but poses challenges for biopharmaceutical production as lactate accumulation inhibits cell growth and protein production. Previous efforts to eliminate lactate production in cells for bioprocessing have failed as lactate

Introduction: The American Association of Neurologic Surgeons guidelines on the management of traumatic spinal cord injury (SCI), updated in 2013, focus on spinal cord perfusion, early decompressive surgery, and venous thromboembolism (VTE) prophylaxis to improve neurological outcome. Research question: How neurocritical care and initial management have changed with the implementation of updated m

Neural implicit representations have recently become popular in simultaneous localization and mapping (SLAM), especially in dense visual SLAM. However, existing works either rely on RGB-D sensors or require a separate monocular SLAM approach for camera tracking, and fail to produce high-fidelity 3D dense reconstructions. To address these shortcomings, we present NICER-SLAM, a dense RGB SLAM system

PURPOSE: Assistance from artefacts and humans are traditionally viewed as separate, and it is often up to the individual to try to combine the different kinds of assistance to suit their needs and preferences. The purpose of this study was to gain new insights into the co-existence of and synergies between artefactual and human assistance in the everyday lives of persons with physical and cognitiv

The issue of riba, that is, interest/the “excess” or “surplus” on loans is crucial for both Islamic and non-Islamic countries. Western economic systems use interest to distribute financial resources efficiently for investment and/or consumption, while Islamic economies pursue a completely different strategy for financing loans, which adheres to Islamic laws and prohibits the activities of conventi

This article aims first to understand how and why forced migrants decide to leavear stay in their first country af asylum, and second to contribute to the theory afagentic analyses af forced displacement. Our contribution adds to the growingbody af research examining the impact af social class and associated capitals anthe trajectories af forced migrants. Our analysis af the protracted displacemen

Which linguistic labels we use to name ourselves and others – such as disabled and non-disabled – make a difference regarding how we see ourselves and each other. Such labels may also say something about how we view society and the roles of people in it, as illustrated by the choice between people-first and identity-first labels. In the present study, we use a sample of 56,666 articles published b

Pool boiling is an effective heat dissipation approach in electronic cooling, battery thermal management, etc. This study used the electrochemical deposition method to fabricate one smooth nickel specimen (named Ni-smooth) and three specimens with a porous nickel-stacked structure. The three porous specimens were created with deposition current densities of 0.5 A·cm–2 (named Ni-0.5), 2.0 A·cm–2 (n

This paper presents millimeter-wave scattering from a building facade predominantly composed of windows. These windows are integrated into the walls, forming dihedral structures that reflect waves toward the incident angle. The scattered field resulting from the building facade is simulated using the two-bounce Geometrical-Physics (GO) method. We analyze the channel in power loss and arrival angle

Wetland methane responses to temperature and precipitation are studied in a boreal wetland-rich region in northern Europe using ecosystem process models. Six ecosystem models (JSBACH-HIMMELI, LPX-Bern, LPJ-GUESS, JULES, CLM4.5, and CLM5) are compared to multi-model means of ecosystem models and atmospheric inversions from the Global Carbon Project and upscaled eddy covariance flux results for thei

Joint diagonalization of collections of matrices, i.e. the problem of finding a joint set of approximate eigenvectors, is an important problem that appears in many applicative contexts. It is commonly formulated as finding the minimizer, over the set of all possible bases, for a certain non-convex functional that measures the size of off-diagonal elements. Many approaches have been studied in the

III-Nitride based LEDs based on InGaN active layers on GaN work very well for the blue and green emitting LEDs. However, the large lattice mis-match between redemitting active layers, with at least 35% indium in the active layers, and the GaN substrate still limits the efficiencies obtained to very low values. Unfortunately, the approach to use GaAs based (GaAs/AlInGaP) devices for the red fails f

In this paper, we present novel key-recovery attacks on Approximate Homomorphic Encryption schemes, such as CKKS, when employing noise-flooding countermeasures based on non-worst-case noise estimation. Our attacks build upon and enhance the seminal work by Li and Micciancio at EUROCRYPT 2021. We demonstrate that relying on average-case noise estimation undermines noise-flooding countermeasures, ev

Objective: To compare the effectiveness of JAK inhibitors (JAKis) and biologic disease-modifying antirheumatic drugs (bDMARDs) on pain in patients with rheumatoid arthritis. Methods: In this retrospective study, we investigated patients with a diagnosis of rheumatoid arthritis, starting treatment with a JAKi (n = 1,827), a tumor necrosis factor inhibitor (TNFi; n = 6,422), an interleukin-6 inhibit