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Type 2 diabetes (T2D) is a major global health concern strongly associated with atherosclerosis and subsequent macrovascular complications. These complications are the leading cause of death among T2D patients. Despite a decline in cardiovascular events over the last decade, individuals with T2D still have an approximately doubled risk compared to those without diabetes. This shows an urgent need
The precision goal on the Cabibbo-Kobayashi-Maskawa matrix elements |Vus| and |Vud| requires the inclusion of isospin-breaking effects. These effects, associated to QED and the light-quark mass difference, can be included in lattice QCD+QED simulations. The long-range nature of QED, however, poses a problem for finite-volume lattice simulations that necessitates the adoption of a prescription for
This paper presents a method for mathematical modelling of surfaces conditioned on empirical data. It is based on solving a discrete biharmonic equation over a domain with given inner point and inner curve data. The inner curve data is used to model boundary values while the inner point data is used for modeling a load vector with the goal to generate a smooth surface. The construction of boundary
This chapter presents the ICECAP-O, a measure of capability tailored for older people. It briefly presents the original version of the ICECAP-O. In addition, it describes the work that has been done concerning the translation and cross-cultural adaptation of the ICECAP-O to the Swedish context. Finally, the chapter contains arguments for the use of the Swedish version of the ICECAP-O in health and
This work investigates how austenite stability and phase composition varies across multiple carbon contents for a cemented carbide with a steel binder alloyed with nickel, chromium and molybdenum. The results are compared with predictions done by thermodynamic calculations and property models designed to predict the austenite stability for steel. It is found that it is possible to predict the mart
We sought to clarify the inter-relationships among a range of psychiatric and substance use disorders by employing two-dimensional genetic maps, with axes defined by family genetic risk for major depression (MD) and drug use disorder (DUD). Using comprehensive Swedish national register data, we located cases of 12 disorders within this space and examined how their genetic risk profiles varied as a
Announced in this Comment and in collaboration with Nature Medicine is the convening of the Data-Driven Decision Support in Obesity Management Commission, to promote adequate scientific evidence to support obesity management across global populations.
Background and Aims: Atherosclerosis is a chronic lipid-driven inflammatory disease and one of the leading underlying causes of cardiovascular morbidity and mortality in Western society. Macrophages are key players in atherosclerotic development. Although the cellular composition of carotid atherosclerotic lesions has been determined, macrophage population definitions lack granularity and lineage
The overall conclusion of the project is that moisture safety cannot be achieved through individual standards, calculation software, or industry regulations alone. Sweden already has many relevant documents: SIS/EN/ISO standards for measurement, material data, climate data, simulation, and diagnostics; AMA as a specification and contractual framework; industry regulations for wet rooms, HVAC and p
ObjectivesHuman service workers are at a greater risk for negative work and health-related outcomes due to the highly demanding nature of their work which involves unique stressors such as emotion work and routine interactions with clients. This scoping review synthesizes the current state of literature reporting on the associations of psychosocial safety climate (PSC) with human service workers’
Background: The major genetic high-risk of developing autoimmune diabetes are HLA-DR3DQ2 and HLA-DR4DQ8 haplotypes. Their importance in Latent Autoimmune Diabetes in Adults (LADA) has only been partly elucidated. Here we aimed to dissect their impact on autoimmunity, diabetic phenotype, and comorbidity. Methods: Data from individuals with LADA were collected from two all-population based surveys,
Background: Machine learning (ML)-based cluster analysis is a common method for subtyping medical conditions and presentations of disease states. Recent advancements in algorithms and increasing access to vast healthcare data have further increased the use of such ML models. However, practical implementation is lacking, largely due to methodological limitations and insufficient reporting and clini
Industry accounts for 26.3 percent of global carbon dioxide emissions and 34 percent if we include the indirect emissions from purchased electricity and heat. Reaching net-zero emissions in a few decades means that industry must also take unprecedent mitigation actions. Given the 15–25-year lifespan of major process equipment, all new industrial investments will need to be near net-zero emissions
Cuffless blood pressure (BP) monitoring devices represent a promising innovation in hypertension management. This scientific statement provides a comprehensive update on these emerging technologies, their specific validation requirements, their potential clinical applications, and their present and future challenges. These devices generate considerable interest by enabling non-invasive BP measurem
Mat för ett inkluderande samhälle är ett samverkansprojekt med finansiering från Sustain-Gov. Det leds av Region Stockholm i samverkan med Livsmedelsakademin, Dietisternas Riksförbund, Frisk Mat (PUSH) och Matmissionen.
Aim: To describe critical care nurses' perceptions and experiences of the organ donation process. Design and Methods: A systematic review with a literature search in CINAHL, PubMed, and PsycINFO was conducted between 2009–2024 and reported by the PRISMA guidelines. 14 qualitative studies were assessed for relevance and methodological quality. Data were extracted by two of the researchers. A qualit
Prosthetic hips have an average life span of 10-15 years before failure due to periprosthetic osteolysis and aseptic loosening, leading to revision total hip replacement. The concept of osseointegration is a key element in determining the longevity of a prosthetic hip. To obtain a stable, long-lasting bond between bone and implant, biological and mechanical cues must be presented in the form of a
One of the parameter in determining the level of organic contaminant in water is Biological Oxygen Demand (BOD). Its principle is the determination of the amount of the dissolved oxygen that will be utilized by aerobic microorganisms for degrading the organic matter in the wastewater. There are several approaches in measuring the BOD value, but in this study, we used the classical method, manometr
This thesis aims to produce and characterize endo-xylanases from the glycoside hydrolase family 5 (GH5) to hydrolyze corn arabinoxylan and produce short-chain oligosaccharides. Five new enzymes from family GH5 were tested, CtXyl5A from Clostridium thermocellum and the GpXyl5 from the fungal GH5_34 gave the best results. DNS assay was performed for the determination of the optimal conditions of the
Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited immune system disorders caused by pathogenic variants in over 400 genes, collectively affecting an estimated one in 10,000 individuals worldwide. The IDbases collection, maintained on the legacy MUTbase platform at Lund University, represents one of the most comprehensively curated repositories of such variants, catalo
