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Objective: The objective of this study was to determine the predictive value of amyloid-positron emission tomography (PET) versus the plasma ratio of phosphorylated tau at threonine 217 (p-tau217) to non-phosphorylated tau217 (%p-tau217) for tau-PET transitions (T− to T+). The added value of combining plasma amyloid-β 42 and amyloid-β 40 (Aβ42/40) and %p-tau217 into an amyloid probability score (A
Revolution in one country can inspire protests in another country, demanding responses from elites seeking to maintain power. Scholars typically use a policy-centered approach to analyze these responses, focusing on how policy strategies of repression or co-optation are used to prevent revolution. But in democracies, political survival is also electoral success. This article therefore argues that
Current electrode technologies are too rigid for safe and effective delivery of electrotherapy in the brain, and patients with glioblastoma continue to face a devastating prognosis, with median survival stalled at 15 months despite intensive treatment with surgery, radiation, and chemotherapy. But these conventional approaches potentially compromise immune function, underscoring the urgent need fo
Polymer-based organic mixed ion-electron conductors (OMIECs) are a class of materials offering unique coupled dual charge transport characteristics along with appealing properties including mechanical softness, biocompatibility, tunability, volumetric capacitance, and stability. These features have been exploited in devices including organic electrochemical transistors (OECTs), neuromorphic comput
Concerns have been raised that transfers of bureaucrats and politicians into the private sector might create unfair advantages for their future employers and even lead to distrust in government. Not surprisingly, the study of the revolving door has therefore gained prominence in the academic literature. Importantly, however, less attention has been paid to the executive branch. We add to the study
This study investigates the practical integration of Building Information Modelling (BIM) and Building Energy Modelling (BEM) for energy-efficient building design. This research explores the challenges and opportunities of openBIM-to-BEM workflows by drawing on a literature review and a real-world case study in Östergötland County, typical of the Million Programme, a large public housing initiativ
In this paper, we investigate how ethical questions of fairness and representation are embedded in processes of commons creation. Drawing on a qualitative case study of a global trend in night management, we show how proponents (including ‘night mayors’ and ‘night councils’) in various cities attempt to reconceptualize urban nights as commons and engage in negotiations around diverse and often con
Article 12 of the UN Convention on the Rights of Persons with Disabilities requires states parties to take appropriate measures to ensure that persons with disabilities have access to the support they may need in exercising their legal capacity. However, this obligation remains ambiguous. What exactly is decision-making support meant to accomplish? Until this fundamental issue has been clarified,
BACKGROUND: Neuroblastoma (NB) is a childhood cancer with a high relapse rate despite intensive treatment. TRPA1 is a pain-sensing ion channel with downstream impacts on proliferative and pro-apoptotic pathways. Here, we evaluated TRPA1 expression in NB and performed pharmacological inhibition in preclinical models to assess its potential as a therapeutic target in NB.METHODS: TRPA1 protein levels
BackgroundWorkplace sexual harassment remains a persistent issue in Sweden. Research about organisational antecedents has been criticised for being limited in scope, possibly overlooking contextual factors relevant for the occurrence of sexual harassment. This study examined two factors capturing aspects of organisational climate, perceived relational justice and authoritarian treatment, and their
BACKGROUND: The ORBITA and ORBITA-2 trials have provided valuable insights into the effects of coronary revascularization in chronic coronary syndrome (CCS). However, uncertainties remain regarding the efficacy of revascularization on symptoms in large real-world populations. To evaluate the efficacy of revascularization, we used dispensed long-acting nitrates as a proxy for the presence of angina
Objective: To determine bone shape changes over two years after acute anterior cruciate ligament (ACL) injury and to compare knees treated with ACL reconstruction (ACLR) vs no ACLR. Design: We used prospective data involving 129 young adults (46 % female, mean age 25 years) with recent ACL injury from a subcohort within the prospective multicenter NACOX study. Patients were treated according to S
BACKGROUND: Psychiatric patients may refer to concepts neither medically accepted nor easily understood to describe their experiences when seeking medical care. These concepts may lie outside the clinician's cultural references and consequently hinder the diagnostic consultation. In the fifth version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), the clinical instrument Cult
Proteins related to the ubiquitin-proteasome system play an important role during the differentiation and ciliogenesis of photoreceptor cells. Mutations in several genes involved in ubiquitination and proteostasis have been identified as causative of inherited retinal dystrophies (IRDs) and ciliopathies. USP48 is a deubiquitinating enzyme whose role in the retina is still unexplored although previ
OBJECTIVES: The Sepsis-3 definition states the clinical criteria for sepsis but lacks clear definitions of the underlying infection. To address the lack of applicable definitions of infection for sepsis research, we propose new criteria, termed the Linder-Mellhammar criteria of infection (LMCI). The aim of this study was to validate these new infection criteria.DESIGN: A multicenter cohort study o
