Environmentally induced phenotypes have been proposed to initiate and bias adaptive evolutionary change toward particular directions. The potential for this to happen depends in part on how well plastic responses are aligned with the additive genetic variance and covariance in traits. Using meta-analysis, we demonstrate that plastic responses to novel environments tend to occur along phenotype dim

Objective: Infliximab-treated patients with rheumatoid arthritis (RA) may respond insufficiently due to low serum infliximab (sIFX) levels, caused by anti-drug antibodies (ADAs). However, monitoring of sIFX and ADAs is not routinely implemented, and levels for optimal outcome have not been validated. We searched for predictors for sIFX < 0.2 μg/mL and ADA development in a randomized setting. Metho

Flowers and fruits of Zlivifructus microtriasseris, originally described as Caryanthus microtriasseris from the late Turonian to Santonian of the South Bohemian Basins and the late Coniacian to early Santonian of the North Sudetic Basin, are reinterpreted here. Zlivifructus microtriasseris is represented by small, flat fruits, round in outline with persistent perianths, which are fused basally, fo

The study of Precambrian dyke swarms, sill provinces and large igneous provinces on the Kalahari craton in southern Africa has expanded greatly since the pioneering work initiated almost four decades ago. The main contributors to this progress have been a large number of precise U–Pb crystallization ages of mafic rocks, published in a number of recent papers. This information is compiled here into

The present study focuses on NNE-trending dykes (sites LDA to LDJ) that occur near Mashishing in the eastern Kaapvaal craton. The Mashishing dykes were previously considered to be coeval and regarded as the extension of the 1.875–1.835Â Ga Black Hills dyke swarm into the sedimentary rocks of the Pretoria Group. Thin sections exhibit well-preserved igneous textures, with primary minerals (e.g., hor

Background: There are limited data on ultrasound morphologic features of gestational trophoblastic neoplasia. A predictive model to determine predictors of response to therapy would be ideal in the management of patients with this rare disease. Primary Objectives and Study Hypothesis: TITANIUM is a prospective, multicenter, observational study aiming to describe ultrasound features of gestational

AIMS: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by ventricular arrhythmias (VAs) and sudden cardiac death (SCD). We aimed to develop a model for individualized prediction of incident VA/SCD in ARVC patients. METHODS AND RESULTS: Five hundred and twenty-eight patients with a definite diagnosis and no history of sustained VAs/SCD at baseline, aged 38.2 ± 15.5

Many plants dramatically elongate their stems during flowering, yet how this response is coordinated with the reproductive phase is unclear. We demonstrate that microRNA (miRNA) control of APETALA2 (AP2) is required for rapid, complete elongation of stem internodes in barley, especially of the final 'peduncle' internode directly underneath the inflorescence. Disrupted miR172 targeting of AP2 in th

This article describes the Swedish kidney exchange program (STEP) and the first donations and transplantations that were performed in October 2018. A total of six parallel surgical procedures resulted in three kidney donations and three kidney transplantations. Two months after the operations, all recipients had good and stable kidney function and all donors had recovered. We argue that four speci

Objective To examine the impact of maternal healthcare (MHC) utilisation on routine immunisation coverage of children in Nigeria. Design Individual level cross-sectional study using bivariate and multivariable logistic regression analyses to examine the association between MHC utilisation and routine immunisation coverage of children. Setting Nigeria Demographic and Health Survey 2013. Participant

We analyze the downlink of a massive multiuser multiple input, multiple output (MIMO) system where antenna units at the base station are connected in a daisy chain without a central processing unit and only possess local channel knowledge. For this setup, we develop and analyze a linear precoding algorithm for suppressing interuser interference. It is demonstrated that the algorithm is close to ze

With an increased focus on reducing greenhouse gas emissions, energy saving is of great importance in all sectors of society. EU directives set targets for member states to reduce energy use in buildings. Energy saving in historic buildings requires special measures, balancing energy-saving renovations against the preservation of heritage values. Traditional constructions are open to vapor diffusi

Infectious diseases are the primary cause of mortality worldwide. The dangers of infectious disease are compounded with antimicrobial resistance, which remains the greatest concern for human health. Although novel approaches are under investigation, the World Health Organization predicts that by 2050, septicaemia caused by antimicrobial resistant bacteria could result in 10 million deaths per year

The utility of mRNA and protein determinations of G protein-coupled receptor 35, that is, GPR35a (GPR35 V1) and GPR35b (GPR35 V2/3), as indicators of outcome for colon cancer patients after curative surgery was investigated. Expression levels of V1 and V2/3 GPR35, carcinoembryonic antigen and CXCL17 mRNAs were assessed in primary tumours and regional lymph nodes of 121 colon cancer patients (stage

This paper deals with the enactment of power in and through a sharing economy business model. The objective of research is to understand business models as a kind of narrative performance that mobilise labour, capital and users on a startup platform within adventure tourism. The paper elaborate on the dynamics between performances and power in terms of how the narratives performed by the platform