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Pathophysiology and treatment of defective insulin secretion Defective insulin secretion is a central feature in diabetes mellitus and results from reduced pancreatic beta-cell mass as well as aberrant beta-cell function. The pathophysiology of diabetes is incompletely known, but a strong hereditary component is suggested. This thesis investigates the genetic and cellular basis for impaired insuli

https://www.ludc.lu.se/education-training/theses/theses-2007/anders-rosengren - 2025-10-01

Candidate Genes for Late Diabetic Complications Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The new WHO criteria for classification of diabetes takes into account also clinical stages dividing the diabetic patients into noninsulin requiring (NIR), insulin requiring for control (IRC) and insu

https://www.ludc.lu.se/education-training/theses/theses-2007/eero-lindholm - 2025-10-01

Heritability of blood pressure monogenes and polygenes High blood pressure (BP) is associated with cardiovascular morbidity and mortality. Both genetic and environmental factors are implicated in BP homeostatsis and hypertension development. The aims of the present theisis were: (a) to test if ambulatory BP (ABP) is better than office BP (OBP) to capture the heritable part of BP and if BP variabil

https://www.ludc.lu.se/education-training/theses/theses-2007/cristiano-fava - 2025-10-01

From the pancreatic beta cell to the endothelium: Pathophysiological aspects of Type 2 diabetes The incidence of Diabetes Mellitus increases globally in epidemic proportions. Type 2 Diabetes is the most prevalent form of Diabetes, comprising 90% of the patients. In Type 2 Diabetes, two processes contribute to the development of the disease: insufficient insulin secretion from the pancreatic ?-cell

https://www.ludc.lu.se/education-training/theses/theses-2007/marloes-dekker-nitert - 2025-10-01

Assessment and Treatment of Impaired Insulin-Secretion and Action in Type 2 Diabetes Type 2 diabetes (T2D) is a disease characterised by varying degrees of defect in insulin secretion and insulin sensitivity and associated with increased morbidity and mortality. Optimal glycaemic control reduces the progression of diabetic complications. Over time, there is a steady deterioration of glycaemic cont

https://www.ludc.lu.se/education-training/theses/theses-2008/mozhgan-dorkhan - 2025-10-01

Adipose Tissue Gene Expression & Candidate Genes for Obesity Obesity results from an interaction between genetic and environmental factors and is a growing health problem associated with development of insulin resistance, type 2 diabetes and cardiovascular disease. This thesis has focused on investigating the genetic contribution in obesity and insulin resistance by both candidate and global gene

https://www.ludc.lu.se/education-training/theses/theses-2008/lovisa-e-johansson - 2025-10-01

Genetics of Type 2 Diabetes and Metabolic Syndrome: From Genome Wide Linkage Scans and Candidate Genes to Genome Wide Association Studies Type 2 diabetes (T2D) and metabolic syndrome (MetS) are major health problems associated with cardiovascular disease. Both diseases are influenced by a combination of genetic and environmental factors. The aim of this thesis was to identify genetic risk factors

https://www.ludc.lu.se/education-training/theses/theses-2008/marketa-sjogren - 2025-10-01

Beta-Cell Dysfunction in Huntington´s Disease Huntington's disease (HD), a fatal neurodegenerative disorder, is associated with an increased risk of diabetes mellitus. The reason for this is unknown, but considering the functional similarities of neurons and the insulin secreting pancreatic β-cell, pathological mechanisms may be shared by both cell types and account for neuronal as well as endocri

https://www.ludc.lu.se/education-training/theses/theses-2009/karl-bacos - 2025-10-01

The Impact of Ethnicity on type 2 Diabetes Type 2 diabetes mellitus is among the fastest growing diseases in the world. The reported prevalence of T2D appears to differ among various ethnic groups. Although ethnic-related differences in lifestyle factors may account for some of the predisposition to diabetes in various ethnic groups, genetic factors may play a more determinant role.High prevalence

https://www.ludc.lu.se/education-training/theses/theses-2009/forouzan-glans - 2025-10-01

Mitochondrial and Chromosomal Genomics in Type 2 Diabetes Understanding the mechanisms of complex polygenic diseases like type 2 diabetes (T2D) is as complex as their nature. Cellular processes involved in glucose homeostasis need high and reliable energy supply. Mitochondria are the major energy producers in mammalian cells. Since majority of the mitochondrial genes are encoded by the nuclear gen

https://www.ludc.lu.se/education-training/theses/theses-2009/avinash-abhyankar - 2025-10-01

Beta Cell Function: from Human Genetics to Animal Models Beta cell function is an important factor in the development of both Type 1 (T1D) and Type 2 (T2D) diabetes mellitus. T1D is characterized by a primary defect in insulin secretion due to the immune-mediated beta cell destruction, however, the more common T2D beside insulin resistance also include impaired beta cell function as a consequence

https://www.ludc.lu.se/education-training/theses/theses-2009/martins-kalis - 2025-10-01

Integrating bioinfomatics and physiology to describe genetic affects in complez polygenic diseases Type 2 diabetes mellitus (T2DM) results from interaction between genetic and environmental factors. The worldwide prevalence of T2DM is increasing rapidly due to reduction in physical activity, increase in dietary intake, and the aging of the population. This thesis has focused on dissecting the gene

https://www.ludc.lu.se/education-training/theses/theses-2009/hemang-parikh - 2025-10-01

Exploring the Grey Zone between Type 1 and Type 2 Diabetes T1D is most common in children and young adults and is characterized by autoimmune destruction of insulin producing pancreatic beta cells, presence of certain risk genotypes such as HLA-DQB1, INS VNTR, PTPN22 and need of insulin for survival. In adults the same situation is often referred to as Latent Autoimmune Diabetes in Adults (LADA),

https://www.ludc.lu.se/education-training/theses/theses-2009/ekaterine-bakhtadze - 2025-10-01

Genetic and Metabolic Markers for the Development of Diabetes after Gestational Diabetes Mellitus The aims of this work were to determine the prevalence of postpartum diabetes among women with gestational diabetes mellitus (GDM) in a prospective study 5 years postpartum; to characterize these women according to insulin secretion, insulin sensitivity, autoimmunity and genetics; and to identify poss

https://www.ludc.lu.se/education-training/theses/theses-2010/magnus-ekelund - 2025-10-01

Regulation of Glucagon Secretion from pancreatic alpha cells Glucagon secreted by pancreatic α-cells plays an important role in the regulation of blood glucose. In this thesis, different techniques such as electrophysiology, immunohistochemistry and hormone secretion assay were combined to explore the mechanisms by which glucagon secretion is regulated. Like pancreatic β-cells, which produce insul

https://www.ludc.lu.se/education-training/theses/theses-2010/yang-zhang-de-marinis - 2025-10-01

Molecular Etiology of Graves´ Disease and Associated Ophthalmopathy Graves' disease (GD) is a complex autoimmune disorder characterized by hyperthyroidism and diffuse goitre. 25-50% of the patients with GD develop eye symptoms, Graves' ophthalmopathy (GO). The overall aim of this thesis was to explore the molecular etiology of GD and GO. By studying gene expression in Studies I, III, and IV, we de

https://www.ludc.lu.se/education-training/theses/theses-2010/tereza-planck - 2025-10-01

Member of the Hjelt Foundation, Geneva

https://www.ludc.lu.se/innovation/innovation-board/paola-hjelt - 2025-10-01

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https://www.ludc.lu.se/innovation/innovation-board/sibylle-lenz - 2025-10-01

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https://www.ludc.lu.se/innovation/innovation-board/peter-morck-eriksen - 2025-10-01

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https://www.ludc.lu.se/innovation/innovation-board/rolf-ehrnstrom - 2025-10-01