The neural cells and factors determining normal vascular growth are not well defined even though vision-threatening neovessel growth, a major cause of blindness in retinopathy of prematurity (ROP) (and diabetic retinopathy), is driven by delayed normal vascular growth. We here examined whether hyperglycemia and low adiponectin (APN) levels delayed normal retinal vascularization, driven primarily b

Reprogramming of cellular identity using exogenous expression of transcription factors (TFs) is a powerful and exciting tool for tissue engineering, disease modeling, and regenerative medicine. However, generation of desired cell types using this approach is often plagued by inefficiency, slow conversion, and an inability to produce mature functional cells. Here, we show that expression of constit

Meteorites have captured our fascination since our early history-they have evoked awe, fear, an irresistible curiosity, and numerous lively debates. Former historians have indicated that many of the ancient cultures and civilizations in Europe, Africa, Asia, the Inuit, and the native Indians in America regarded both the meteorite and the location of their fall as sacred. Thus, they used the meteor

The Kago deposit is a small deposit located at the southern tip of the Satsuma Peninsula of Southern Kyushu, Japan. It lies proximal to the well-known Nansatsu-type mineralisation province dominated by high-sulfidation type epithermal deposits. The deposit was heavily mined in the 18 th Century, largely for its relatively higher gold compared to that of surrounding and regional deposits. The Kago

Escalation (macroevolutionary increase) or divergence (disparity between relatives) in trait values are two frequent outcomes of the plant-herbivore arms race. We studied the defences and caterpillars associated with 21 sympatric New Guinean figs. Herbivore generalists were concentrated on hosts with low protease and oxidative activity. The distribution of specialists correlated with phylogeny, pr

This book, the concluding book in a series of three, analyses the Hebrew word chesed. This word is often translated into English as “grace” or “mercy”, but it can also be understood as, e.g., “solidarity”, “covenantal loyalty” and “generosity”. The book also addresses the dichotomy “law and grace”, and especially how some understandings of these theological concepts may need to be redefined, refin

A comparison was made between two plant peroxidases, cationic horseradish peroxidase (HRP) and anionic tobacco peroxidase (TOP), combined with a highly cationic osmium polymer [Os(4,4'-dimethyl-2,2'-bipyridine)2poly(N-vinylimidazole)10Cl]+2/+ ([Os(dmp)PVI]+/2+) to develop highly sensitive, stable and selective hydrogen peroxide biosensors. The two different plant peroxidases were individually immo

BACKGROUND: Lymphedema leads to adipose tissue deposition. Water-fat magnetic resonance imaging (MRI) can quantify and localize fat and water. The presence of excess fat and excess water/muscle in the subfascial compartment of the lymphedematous limb has not been investigated before. The aim of this study was to investigate epifascial and subfascial fat and water contents in patients with chronic

Most spatiotemporal studies treat spatial and temporal analysis separately. However, spatial and temporal changes occur simultaneously and are correlated. In this study, we propose a generic framework to simultaneously analyse the spatial and temporal variations of water quality on a catchment scale. Specifically, we analyse the heterogeneity of temporal evolution of water quality data among diffe

In this study, an innovative idea of using a plane circular raft surrounded by a water tank is tested numerically using finite element simulations and compared with a conventional piled foundation concerning the geotechnical behavior. Cost comparisons are done for two foundation solutions. An observed soil profile found in Port-Said region in Egypt is used. The soil profile is implemented in the F

HCCI (Homogeneous Charge Compression Ignition) is a very control-intensive combustion concept which has been studied for over a decade because of its favorable combination of high efficiency and low emissions. Various optimal control methods have been applied to HCCI and this chapter gives an overview of them. Optimal control of HCCI can be divided into model based and non-model based where MPC is

Partially premixed combustion is a compression ignited combustion strategy where high exhaust gas recirculation (EGR) levels in combination with early or late injection timing result in a prolonged ignition delay yielding a more premixed charge than with conventional diesel combustion. With this concept it is possible to get low smoke and NOx emissions simultaneously. Accurate control of injection

Digital technologies in health care areexpected to increase in scope and to affect ever more partsof the health care system. It is important to enhance theknowledge of whether new digital methods and innovationsprovide value for money compared with traditional modelsof care.Objective The objective of the study was to evaluatewhether a digital health care model for primary care is aless costly alte