INTRODUCTION: Amyloid beta and tau pathology are the hallmarks of sporadic Alzheimer's disease (AD) and autosomal dominant AD (ADAD). However, Lewy body pathology (LBP) is found in ≈ 50% of AD and ADAD brains. METHODS: Using an α-synuclein seed amplification assay (SAA) in cerebrospinal fluid (CSF) from asymptomatic (n = 26) and symptomatic (n = 27) ADAD mutation carriers, including 12 with known

Aim: To compare the adherence to gluten-free diet between children with serology-based and biopsy-proven coeliac disease. Methods: Medical records were retrospectively reviewed in 257 Swedish children diagnosed with coeliac disease between 2012 and 2019 at a tertiary hospital. Adherence to a gluten-free diet was systematically assessed by trained dietitians at follow-up. Mixed models were used to

Incomplete wildfire combustion in boreal forests leaves behind legacy plant-soil feedbacks known to restrict plant biodiversity. These restrictions can inhibit carbon recapture after fire by limiting ecosystem transition to vegetation growth patterns that are capable of offsetting warmth-enhanced soil decomposition under climate change. Here, we field-surveyed plant regrowth conditions 2 years aft

We present a method that allows enabling matrix element corrections (MECs) in Pythia8 with MC@NLO matching, without incurring double counting. MECs are an interesting feature that may contribute to the accuracy of theoretical predictions, alongside matching and merging. We directly compare our method to a specific choice of settings in Pythia8, which can remove double-counting for MECs in certain

Dominant agri-food systems are increasingly seen as unsustainable in terms of environmental degradation, mass production or high food waste. In an attempt to counteract these developments and foster sustainability transitions in agri-food systems, a variety of actors are engaging in socially innovative models of food production and consumption. Using a multiple case study approach, our study exami

This paper studies the economic impacts of land ownership concentration among the aristocratic elite in the Russian Empire. I document that areas with a higher concentration of noble land ownership were associated with lower levels of primary education during 1880-1911. Exploring the mechanisms, I show that by controlling local governments the landed elites decreased public spending on education,

Purpose: The number of women living with breast cancer (BC) is increasing, and the efficacy of surveillance programs after BC treatment is essential. Identification of links between mammographic features and recurrence could help design follow up strategies, which may lead to earlier detection of recurrence. The aim of this study was to analyze associations between mammographic features at diagnos

Background: Collegial conversations are important for sustainable learning to last beyond a course. Research on collegial conversations and peer learning in the workplace during psychiatric residency courses remains sparse, however. In this study, the aim was to explore residents’ opportunities for collegial conversations during and after national courses in psychiatry. Methods: Residents in psych

The two-dimensional electron gas (2DEG) that forms on a semiconductor surface can be used to explore a variety of phenomena in quantum physics and plays an important role in nanoscale electronics, such as transistors. Controlling its formation is, thus, relevant. Using angle-resolved photoemission spectroscopy (ARPES) and accumulating the signal over many nanocrystals, we find that on clean InAs n

Radiative corrections are crucial for modern high-precision physics experiments, and are an area of active research in the experimental and theoretical community. Here we provide an overview of the state of the field of radiative corrections with a focus on several topics: lepton–proton scattering, QED corrections in deep-inelastic scattering, and in radiative light-hadron decays. Particular empha

The two phases of El-Niño-Southern Oscillation (ENSO) influence both regional and global terrestrial vegetation productivity on inter-annual scales. However, the major drivers for the regional vegetation productivity and their controlling strengths during different phases of ENSO remain unclear. We herein disentangled the impacts of two phases of ENSO on regional carbon cycle using multiple data s

This paper describes the synthesis, structural analysis, as well as the magnetic and spectroscopic characterizations of three new dicopper(II) complexes with dinucleating phenol-based ligands containing different thioether donor substituents: aromatic (1), aliphatic (2) or thiophene (3). Temperature-dependent magnetometry reveals the presence of antiferromagnetic coupling for 1 and 3 (J = −2.27 cm

Glypicans are linked to various aspects of neoplastic behavior, and their therapeutic value has been proposed in different cancers. Here, we have systematically assessed the impact of GPC4 on cancer progression through functional genomics and transcriptomic analyses across a broad range of cancers. Survival analysis using TCGA cancer patient data reveals divergent effects of GPC4 expression across

Paclitaxel eluting balloons and stents reduce the development of intimal hyperplasia and restenosis rate after endovascular treatment for peripheral arterial disease (PAD) in the lower extremities. As diabetes mellitus (DM) worsens the prognosis in PAD patients after invasive endovascular treatment, we assessed the effects of drug eluting technology for PAD with special focus on effects in patient

Worldwide vitamin D insufficiency is remarkably prevalent in both children and adults, including pregnant women. The total amount of the vitamin is best measured by 25-hydroxy-vitamin D (25(OH)D), which is a measurement of total serum cholecalciferol 25 (OH)D3 and ergocalciferol 25(OH)D2. There is a known correlation between maternal and umbilical cord blood (UCB) 25(OH)D; however, whether specifi

Tetrodotoxin (TTX) is a marine toxin responsible for many intoxications around the world. Its presence in some pufferfish species and, as recently reported, in shellfish, poses a serious health concern. Although TTX is not routinely monitored, there is a need for fast, sensitive, reliable, and simple methods for its detection and quantification. In this work, we describe the use of an automated pa

People living in urban and industrialized societies, which are expanding globally, spend more than 90% of their time in the indoor environment, breathing indoor air (IA). Despite decades of research and advocacy, most countries do not have legislated indoor air quality (IAQ) performance standards for public spaces that address concentration levels of IA pollutants. Few building codes address opera