Pioneering studies performed over the past few decades demonstrate links between epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most rapidly increasing prevalence in the world. Importantly, these studies identified epigenetic modifications, including altered DNA methylation, in pancreatic islets, adipose tissue, skeletal muscle and the liver from individuals with

Energy metabolism dyshomeostasis is associated with multiple health problems. For example, abundant epidemiological data show that obesity and overweight increase the risk of cardiometabolic diseases and early mortality. Type 2 diabetes (T2D), characterized by chronically elevated blood glucose, is also associated with debilitating complications, high healthcare costs and mortality, with cardiovas

Leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins have been implicated as regulators of growth factor signaling; however, the possible redundancy among mammalian LRIG1, LRIG2, and LRIG3 has hindered detailed elucidation of their physiological functions. Here, we show that Lrig-null mouse embryonic fibroblasts (MEFs) are deficient in adipogenesis and bone morphogenetic protein (B

T-cell lymphoma (TCL) is a rare group of malignancies and one of the important aims in this thesis has been to broaden the general knowledge of TCL with descriptive patient data. Main focus has been to examine prognosticfactors for overall survival (OS) and progression-free survival (PFS), and to evaluate different treatment approaches and follow-up (FU) after treatment.The purpose of the first st

The intensifying effects of climate change are becoming one of the main threats to cultural heritage, posing risks of degradation or destruction. Climate change is bringing complexity and uncertainty to ensuring the resilience of cultural heritage, and among risk mitigation measures digitalisation is regarded as a promising tool. However, the infrastructure required for the digitalisation process

Background: A negative oral contrast agent (OCA) has been long sought for, to better delineate the bowel and visualise surrounding structures. Lumentin® 44 (L44) is a new OCA formulated to fill the entire small bowel. The aim of this study was to compare L44 with positive and neutral conventional OCA in abdominal computed tomography (CT). Methods: Forty-five oncologic patients were randomised to r

It is concluded that Melandrium glutinosum Rouy belongs in Sectíott jilisanthe oí Silene. It is certainly a distinct species and ¡ts correct ñame is S. marigii.A description is given. The species is believed to be endemic to the Iberian península and occurs among granite bonlders in the mountains of central Spain and northwest Portugal.Resumen. Se concluye que Melandrium glutinosum pertenece a la

Numerical analyses (multidimensional scaling and Bk non-hierarchic cluster analysis) of wild populations of Silene dioica (L.) CIairv. from Scotland showed a complex pattern of variation, related partly to habitat and partly to geographic location. Subsets of characters- flower/capsule, seed, and vegetative characters- showed discordance, i.e. imperfectly correlated patterns of variation.Material

Silene alba Muhl. ex Britton (1893), although considered to be an illegitimate substitution for S. nivea (Nutt.) Otth, is validly published and as a result S. alba (Miller) E. H. L. Krause (1901), the widely used name for the weed white campion or white cockle, is illegitimate. It is shown that the correct name for this species in Silene is S. pratensis (Rafn) Godron & Gren. A new taxonomic tr

The paper examines how interjections have been treated in linguistic literature; on what grounds they have been separated from pure response cries; and what their relation is to iconic (onomatopoeic) vocabulary items. Second, the paper examines various English grammars intended for university level students, especially in second language contexts, to see how their treatment of interjections reflec

Abstract:A pair of morphologically differentiated sex chromosomes is reported from the Valencian endemic, Silene diclinis. In S. diclinis, the sex chromosomes differ in centromere position, but X and Y chromosomes are approximately equal in length. In the other dioecious species in Silene sect. Elisanthe, the Y chromosome is considerably longer than the X chromosome.Resumen:Se da noticia de un par