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Heart failure (HF) affects 64 million people worldwide. Despite advancements in prevention and therapy, quality of life remains poor for many HF patients due to associated target organ damage. Pulmonary manifestations of HF are well-established. However, difficulties in the treatment of HF patients with chronic lung phenotypes remain as the underlying patho-mechanistic links are still incompletely
Different aspects of the novel have changed at a different pace. If one compares modernist novels with those of a 100 years previously, not only is an inward turn noticeable but also an outward turn: the sky, for example, is much more present. This change does not, however, coincide with the Victorian-modernist divide but rather comes when the influence of romantic poetry reaches the novel. This c
Every EU country must adapt its national regulations to the common EU and ECHR standards. There is, however, a certain discretion to apply the EU standards into national legislation. For those in need of protection, is Sweden more or less generous in comparison to the EU’s minimum rules?This study examines Swedish asylum legislation from a European perspective. Although EU Member States are bound
BackgroundThe knowledge about striatal hand deformities (SHD) in Parkinson’s disease (PD), has recently increased but need more attention due to their early impact on dexterity. The focus of clinical studies has been on the staging of SHD severity and neurological features. However, a hand surgical perspective has not been considered.ObjectivesOur purpose was to examine SHD in patients with PD usi
The particular properties of argumental compounds in Italian pose interesting theoretical challenges, and investigations of possible syntactic operations within this type of complex words have resulted in conflicting conclusions. Regarding compoundinternal anaphora, some researchers exclude the possibility that pronouns can refer to the non-head, while others do not. However, these findings have b
Framtiden är gammal. Mötet med morgondagen har sannolikt upptagit människors medvetande från allra äldsta tid. Här presenteras hela framtidens historia, från babyloniernas stjärntydningar till våra dagars hamstring och prepping. I huvudsak behandlas människors föreställningar, visioner, önskningar och rädslor inför framtiden i olika kontexter och under olika historiska epoker.
Protein-protein interactions are crucial in numerous cellular functions and biological processes that take place inside our body. It is therefore not surprising that these interactions also govern the response of our body´s defence mechanism, the so-called immune system, towards an infection. Understanding how proteins interact entails studying the binding affinity (strength) and the lifetime (dur
The use of molecular data to study the evolutionary history of organisms has revolutionized the field of systematics. Now with the appearance of high throughput sequencing (HTS) technologies, more and more genetic sequence data are available. One of the important sources of genetic data for phylogenetic analyses has been mitochondrial DNA. The limitations of mitochondrial DNA for the study of phyl
Abstract: Sensory impairments in the upper limb are common after stroke. Different sensory modalities can be affected such as sense of touch, pressure, pain, temperature and proprioception. The sensory impairments can negatively affect motor function, dexterity and the ability to perform daily activities. Despite these problems limited attention is paid to sensory impairments in stroke rehabilitat
The aim of this chapter is twofold. First, it deliberates the insufficiency of the ethnically loaded hyphenated identity of ‘Euro-Turks’ in defining the diverse diasporic community of Turkey’s citizens and/or their descendants in Europe. Second, it lays out the advantages and disadvantages of using the Türkiyeli concept as an alternative to the hyphenated identity Euro-Turks, which allows peoples
Acute respiratory distress syndrome (ARDS) is a life-threatening, high mortality pulmonary condition characterized by acute lung injury (ALI) resulting in diffuse alveolar damage. Despite progress regarding the understanding of ARDS pathophysiology, there are presently no effective pharmacotherapies. Due to the complexity and multiorgan involvement typically associated with ARDS, animal models rem
Tricuspid regurgitation (TR) is a highly prevalent condition and an independent risk factor for adverse outcomes. Multiple clinical guidelines exist for the diagnosis and management of TR, but the recommendations may sometimes vary. We systematically reviewed high-quality guidelines with a specific focus on areas of agreement, disagreement, and gaps in evidence. We searched MEDLINE and EMBASE (1 J
Plants respond to mechanical stimuli to direct their growth and counteract environmental threats. Mechanical stimulation triggers rapid gene expression changes and affects plant appearance (thigmomorphogenesis) and flowering. Previous studies reported the importance of jasmonic acid (JA) in touch signaling. Here, we used reverse genetics to further characterize the molecular mechanisms underlying
The Covid-19 pandemic has revealed the importance of social protection systems, including income security, when health problems arise. The aims of this study are to compare the follow-up regimes for sick-listed employees across nine European countries, and to conduct a qualitative assessment of the differences with respect to burden and responsibility sharing between the social protection system,
Background: Preclinical rodent models of Parkinson's aim to recapitulate some of the hallmarks of the disease as it presents in humans, including the progressive neuronal loss of dopaminergic neurons in the midbrain as well as the development of a behavioral phenotype. AAV vector-based models of alpha-synuclein overexpression are a promising tool to achieve such animal models with high face and pr
