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Anthropologists have generally found it reasonable to understand the Industrial Revolution in Britain as a product of global historical processes including colonialism and the structure of world trade. The extent to which the industrialization of British textile production was contingent on global processes has been illuminated in detail by historians such as Joseph Inikori. Andre Gunder Frank pro

Neuroinflammation is associated with l-DOPA treatment in Parkinson's disease (PD), suggesting a role in l-DOPA-induced dyskinesia (LID), however it is unclear whether increased inflammation is specifically related to the dyskinetic outcome of l-DOPA treatment. Diversely from oral l-DOPA, continuous intrajejunal l-DOPA infusion is associated with very low dyskinetic outcome in PD patients. We repro

Rotigotine acts in vitro as a full agonist of dopamine D1 receptors at concentrations almost superimposable to those at which it acts on D2 receptors. However in vivo evidence of the differences between the agonist activity of rotigotine at D1 receptors from that on the D2 receptors has not been provided yet. In order to test the ability of rotigotine to stimulate dopamine D1 and D2 receptors in v

Withania somnifera Dunal (Indian Ginseng) has recently been shown to impair ethanol self-administration. In order to gain further insights on the ability of the Withania somnifera standardised root extract (WSE) to affect the motivational properties of ethanol, this study investigated whether WSE may also affect ethanol (2 g/kg)-elicited conditioned place preference (CPP) and aversion (CPA). To th

Adolescent Cannabis exposure has been hypothesized to act as a gateway to opiate abuse. In order to investigate the role of genetic background in cannabinoid-opiate interactions, we studied the effect of Δ(9) -tetrahydrocannabinol (THC) exposure of adolescent Lewis and Fischer 344 rats on the responsiveness of accumbens shell and core dopamine (DA), as monitored by microdialysis, to THC and heroin

Drugs of abuse possess the seemingly paradoxical property of conditioning rats to avoid from drinking a saccharin solution that had been predictively paired with their systemic administration (conditioned saccharin avoidance, CSA). CSA is dependent upon an intact dopamine (DA) transmission but the locus, central or peripheral, and eventually the brain area from which this effect originates and its

Wide-VDD-range processors offer high energy efficiency for varying embedded workloads. But reducing the VDD of the cache as aggressively as the VDD of the CPU logic is not straightforward, since standard 6T SRAMs cease to operate at lower VDDs. We implement a data and instruction filter cache, using logic cells located in the CPU VDD domain, to permit the level-1 (L1) cache to be reliably powered

Several new architectures are under investigation for cloud radio access networks, assuming distinct splits of functionality among the network elements. Consequently, the research on radio data compression for the fronthaul is based on assumptions that correspond to a wide variety of tradeoffs among data rate, signal distortion, latency, and computational cost. This letter describes a method for L