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Differentiation of diabetes by pathophysiology, natural history, and prognosis
The American Diabetes Association, JDRF, the European Association for the Study of Diabetes, and the American Association of Clinical Endocrinologists convened a research symposium, "The Differentiation of Diabetes by Pathophysiology, Natural History and Prognosis" on 10-12 October 2015. International experts in genetics, immunology, metabolism, endocrinology, and systems biology discussed genetic
Using learning networks to understand complex systems: a case study of biological, geophysical and social research in the Amazon
The crystal structure of staphylococcal enterotoxin H : Implications for binding properties to MHC class II and TcR molecules
The X-ray structure of the superantigen staphylococcal enterotoxin H (SEH) has been determined at 1.69 Å resolution. In this paper we present two structures of zinc-free SEH (apoSEH) and one zinc-loaded form of SEH (ZnSEH). SEH exhibits the conventional superantigen (SAg) fold with two characteristic domains. In ZnSEH one zinc ion per SEH molecule is bound to the C-terminal β-sheet in the region i
Linking Futures across Scales: a Dialog on Multiscale Scenarios
Spectrophotometric methods for the determination of superantigen structure and stability.
Responses to climate change: Exploring organisational learning across internationally networked organisations for development
Branched short-chain fatty acids modulate glucose and lipid metabolism in primary adipocytes
Short-chain fatty acids (SCFAs), e.g. acetic acid, propionic acid and butyric acid, generated through colonic fermentation of dietary fibers, have been shown to reach the systemic circulation at micromolar concentrations. Moreover, SCFAs have been conferred anti-obesity properties in both animal models and human subjects. Branched SCFAs (BSCFAs), e.g., isobutyric and isovaleric acid, are generated