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AIMS: The aim of this study is to investigate how genetic variations in genes related to oxidative stress, intake of antioxidant vitamins, and any potential interactions between these factors affect the incidence of intact abdominal aortic aneurysm (AAA) and its rupture (rAAA), accounting for sex differences where possible.METHODS AND RESULTS: The present retrospective cohort study (n = 25 252) us

This article investigates the creation and circulation of class knowledge among Sweden's political parties as Swedish representative democracy took shape, 1911-1940. When the expanded franchise for men was introduced in the general election of 1911, the National Statistics Bureau (SCB) was tasked with categorising voters to measure the effects of the reform. They created a taxonomy made up of thre

This article investigates an important but understudied phenomenon: the bureaucratic class division, which is analysed as a difference technology for envisioning, studying and managing the population. I examine a long-lived and widely spread taxonomy of the Swedish population into three social groups (Socialgrupper). Specifically, I look at how it influenced the production of statistics and knowle

This article studies conceptualisations of social class in Swedish education research, c. 1945–1960. The article follows knowledge produced about talent and class in state commissions and in the newly expanded social sciences, and how it in turn was interpreted and used in political debates and in the media. I show that the taxonomy of the population in social groups (Socialgrupper) was key for co

Fall- och uppgiftsbeskrivning för INFN50 Business Decision Management

I use the concept of ambivalence—the state of being faced with a choice that cannot be resolved without sacrificing something of value—to approach five contemporary debates in the philosophy of moral responsibility: (1) psychopathy, (2) free will, (3) the emotion of guilt, (4) regret and indirect moral luck, and (5) moral demandingness. Rather than arguing for one theory or another, acknowledging

This thesis comprises an introductory chapter and four papers related to quality control in ECG-based atrial fibrillation (AF) screening. Atrial fibrillation is a cardiac arrhythmia characterized by an irregular rhythm and constitutes a major risk factor for stroke. Anticoagulation therapy significantly reduces this risk, and therefore, AF screening is motivated. Atrial fibrillation screening is o

Historically and traditionally, military work has been closely associated with men. However, the post-Cold War normalization process has brought about a transformation in both the Swedish Armed Forces themselves and the perception of the organization. Normative concerns, including gender equality, have gained significant prominence, compelling the armed forces to embark on various initiatives aime

INTRODUCTION: Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale. METHOD: One thousand forty-five participants underwent tau scans with either 18F-flortaucipir, 18F-MK6240, 18F-PI2

Background and Objectives: There is considerable heterogeneity in the association between increasing β-amyloid (Aβ) pathology and early cognitive dysfunction in preclinical Alzheimer disease (AD). At this stage, some individuals show no signs of cognitive dysfunction, while others show clear signs of decline. The factors explaining this heterogeneity are particularly important for understanding pr

Background: FLASH radiotherapy (RT) is a novel method for delivering ionizingradiation, which has been shown in preclinical studies to have a normal tissuesparing effect and to maintain anticancer efficacy as compared to conventionalRT. Treatment of head and neck tumors with conventional RT is commonlyassociated with severe toxicity, hence the normal tissue sparing effect of FLASHRT potentially ma

Over the past two decades, a new research field dealing with “sustainability transitions” has emerged, analyzing the transformation of socio-technical systems towards more sustainable futures. While there is consensus on the crucial role of the bioeconomy in sustainability transitions research, we argue that the true potential of many bioeconomy innovations is not yet sufficiently recognized and a

Purpose: To identify and evaluate possible causes of poor patient-reported visual function after cataract surgery. Methods: We obtained retrospective data from the Swedish National Cataract Register on patient self-assessed visual function before and after cataract surgery based on the Catquest-9SF questionnaire. We identified patients who self-reported similar or more difficulties postoperatively

Objectives: Patients with antineutrophil cytoplasmatic antibodies-associated vasculitides (AAV) exhibit higher mortality than the general population. In the current study, we assessed whether cluster affiliation based on clinical presentation might predict mortality. Methods: With case record review, the outcomes for a population-based cohort of patients diagnosed with AAV in southern Sweden (catc

Human brown fat tumors (hibernomas) display concomitant loss of the tumor suppressor genes MEN1 and AIP. In the present study, we hypothesized that the brown fat phenotype is attributed to these mutations. Accordingly, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumors, loss of

Introduction: Central venous access devices facilitate home treatment in boys with haemophilia. These are usually fully implanted lines, referred to as ports. Caregivers are taught to manage the port using sterile techniques and maintaining patency by flushing with saline or heparin solution. National and international guidelines for the home care of ports are lacking. Aim: To evaluate if infectio