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Purpose: Tyrosine kinase inhibitors (TKIs) have well-characterized immunomodulatory effects on T and NK cells, but the effects on the humoral immunity are less well known. In this project, we studied TKI-induced changes in B cell-mediated immunity. Methods: We collected peripheral blood (PB) and bone marrow (BM) samples from chronic myeloid leukemia (CML) patients before and during first-line imat

Objectives: We wanted to investigate the effects of postoperative pulmonary hypertension (PHpostop: mean pulmonary artery pressure [MPAP] ≥ 25 mmHg), diastolic pressure gradient (DPG), pulmonary vascular resistance (PVR), and repeated hemodynamic measurements on long-term survival after heart transplantation (HT). Design: Eighty-nine patients who underwent HT at Skåne University Hospital in Lund i

Purpose: To present data from an interim analysis of a Phase II trial designed to determine the feasibility, safety, and efficacy of individualising treatment based on renal dosimetry, by giving as many cycles as possible within a maximum renal biologically effective dose (BED). Method: Treatment was given with repeated cycles of 7.4 GBq 177Lu-DOTATATE at 8-12-week intervals. Detailed dosimetry wa

Firearm-related violence is common in our contemporary world and causes serious harm to humans as well as to the society. One of the countries in which firearm-related violence is increasing is Sweden and its most southern region, Skane, in which Malmo, Sweden's third largest city, is highly affected. If not contained and limited, Sweden risks becoming more and more violent.

Birds have a light-dependent magnetic compass that provides information about the spatial alignment of the geomagnetic field. It is proposed to be located in the avian retina and mediated by a lightinduced, radical-pair mechanism involving cryptochromes as sensory receptor molecules. To investigate how the behavioural responses of birds under different light spectra match with cryptochromes as the

Bacterial taxonomic community analyses using PCR-amplification of the 16S rRNA gene and high-throughput sequencing has become a cornerstone in microbiology research. To reliably detect the members, or operational taxonomic units (OTUs), that make up bacterial communities, taxonomic surveys rely on the use of the most informative PCR primers to amplify the broad range of phylotypes present in up-to

With the Penning-trap mass spectrometer SHIPTRAP at GSI, Darmstadt, it is possible to investigate exotic nuclei in the region of the heaviest elements. Few years ago, challenging experiments led to the direct measurements of the masses of neutron-deficient isotopes with Z = 102; 103 around N = 152. Thanks to recent advances in cooling and ion-manipulation techniques, a major technical upgrade of t

Robust and efficient target-tracking algorithms embedded on moving platforms, are a requirement for many computer vision and robotic applications. However, deployment of a real-time system is challenging, even with the computational power of modern hardware. As inspiration, we look to biological lightweight solutions-lightweight and low-powered flying insects. For example, dragonflies pursue prey

At the end of 2014, a Major Baltic Inflow (MBI) brought oxygenated, salty water into the Baltic proper and reached the long-term anoxic Eastern Gotland Basin (EGB) by March 2015. In July 2015, we measured benthic fluxes of phosphorus (P), nitrogen (N) and silicon (Si) nutrients and dissolved inorganic carbon (DIC) in situ using an autonomous benthic lander at deep sites (170-210 m) in the EGB, whe

Conductivity in mS/m or S/cm gives a rough idea of the amount of dissolved ions in water. Distilled water and reverse osmosis–treated water have extremely low conductivity, while the conductivity of water from sandstone is higher and that of water from limestone (hard water) even higher. Thus, the variation of the contribution of minerals from drinking water is large. A Swedish study on well water

A new perspective on the modelling of settling behaviour in water resource recovery facilities is introduced. The ultimate goal is to describe in a unified way the processes taking place both in primary settling tanks (PSTs) and secondary settling tanks (SSTs) for a more detailed operation and control. First, experimental evidence is provided, pointing out distributed particle properties (such as

Practitioners may face difficulties in the interpretation of fire codes since they often present so called "magic numbers", i.e. numbers available in the codes which are listed for providing the design of building fire safety, for which the derivation and justification are not explained. The present paper discusses the need for a transparent regulatory approach, in which legislators publicly justi

The protagonist projection hypothesis was formulated by Holton (1997) in order to account for cases where the speaker seems to utter contradictory statements. Holton argues that in these cases the speaker projects herself into the mind of someone else. Three different sentence-types have been classified as examples of protagonist projection: (i) sentences with factive verbs (tell+wh, know), (ii) s

The question whether there is a natural connection between sound and meaning or if they are related only by convention has been debated since antiquity. In linguistics, it is usually taken for granted that 'the linguistic sign is arbitrary,' and exceptions like onomatopoeia have been regarded as marginal phenomena. However, it is becoming more and more clear that motivated relations between sound

This article discusses and analyzes mothering that crosses boundaries of care in spite of differences of nationality, culture and religion. Swedish missionary Alma Johansson was one of a remarkable number of women missionaries who volunteered as relief workers during the Armenian refugee crisis. These women missionaries were often seen as mothers who were ‘saving a whole generation’. The article s

The classification of 2 532 new settlements in the Census of India 2011 as 'urban', and specifically as 'Census Towns', has brought small and emerging urban centres back into the purview of urban studies and urban development in India. Taking this to be a point of entry, this article seeks to explore how the urban has been framed and approached from different and competing epistemological standpoi

Sepsis is one of the leading causes of mortality and morbidity in the world, and is an overreaction by the immune system due to pathogen invasion of the bloodstream. The interactions, particularly the protein interactions, between the host and pathogen are fundamental for the outcome of the disease. However, some of the protein interactions are unknown and those that are known have been studied as