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RIFM fragrance ingredient safety assessment, butyl 10-undecenoate, CAS Registry Number 109-42-2

Butyl 10-undecenoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog methyl undec-10-enoate (CAS # 111-81-9) show that butyl 10-undecenoate is not expected to be genotoxic. Data on butyl 10-undecenoate and read-across analog methyl

Early Adolescents’ Emotional and Behavioral Difficulties, Student–Teacher Relationships, and Motivation to Defend in Bullying Incidents

Background: School bullying is a widespread phenomenon across the world, which involves bystanders who take on various roles. Motivation to defend victims is important to investigate because it helps us devise better, evidence-based, anti-bullying interventions. Objective: We aimed to determine whether students’ behavioral and emotional strengths and difficulties and student–teacher relationships

Fine crushing of iron ore through technical-economical optimization technologies

Since the Dawn of Man the metallic iron has been a giant issue for the daily life of humans by using for developments and generality prosper. This "hot" metal is still the most wanted and needed metal for all mankind. Sandvik Mining and Construction has for the last ten years increased our knowledge for the development for crushers, crushing and crusher automation and we have created new frontiersSince the Dawn of Man the metallic iron has been a giant issue for the daily life of humans by using for developments and generality prosper. This "hot" metal is still the most wanted and needed metal for all mankind. Sandvik Mining and Construction has for the last ten years increased our knowledge for the development for crushers, crushing and crusher automation and we have created new frontiers

Vicarious Value Learning and Inference in Human-Human and Human-Robot Interaction

Among the biggest challenges for researchers of human-robot interaction is imbuing robots with lifelong learning capacities that allow efficient interactions between humans and robots. In order to address this challenge we are developing computational mechanisms for a humanoid robotic agent utilizing both system 1 and system 2-like cognitive processing capabilities. At the core of this processing

Using Multi-Agent Transport Simulations to Assess the Impact of EV Charging Infrastructure Deployment

Over the last two decades, electrification has gained importance as a means to decarbonise the transport sector. As the number of Electric Vehicles (EVs)increases, it is important to consider broader system aspects as well, especially when deciding the type, coverage, size and location of the charging infrastructure required. In this article, a Multi-Agent model depicting long distance transport i

The experimental determination of equilibrium Si isotope fractionation factors among H4SiO4 o, H3SiO4 and amorphous silica (SiO2·0.32 H2O) at 25 and 75 °C using the three-isotope method

The accurate interpretation of Si isotope signatures in natural systems requires knowledge of the equilibrium isotope fractionation between Si-bearing solids and the dominant Si-bearing aqueous species. Aqueous silicon speciation is dominated by silicic acid (H4SiO4 o) in most natural aqueous fluids at pH < 8.5, but forms H3SiO4 −, H2SiO4 2−, and polymeric Si species in more alkaline fluids. In th

Performance Estimation of a Traction Machine with Direct Cooled Hairpin Winding

Hollow and profiled conductors, which can be categorized as direct cooled conductors, are selected to develop a design proposal of an electrical machine with direct cooled hairpin type of winding. The objectives of this work are 1) investigating the benefits of direct heat removal when using hollow and profiled conductors, and 2) analyzing high frequency capability of these types of windings. Firs

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To deeply understand the non-premixed swirl flame, the effects of two burner exit geometries on the non-premixed swirl flames modes were studied by performing OH-PLIF, PIV measurements and coupling LES with PDF combustion model numerically. The results showed that the stochastic PDF method can predict the swirl flow fields and detailed flame structures including local extinction. Two different qua

The role of plasma microseminoprotein-beta in prostate cancer : An observational nested case-control and Mendelian randomization study in the European prospective investigation into cancer and nutrition

Background: Microseminoprotein-beta (MSP), a protein secreted by the prostate epithelium, may have a protective role in the development of prostate cancer. The only previous prospective study found a 2% reduced prostate cancer risk per unit increase in MSP. This work investigates the association of MSP with prostate cancer risk using observational and Mendelian randomization (MR) methods. Patients

Allergic contact dermatitis caused by isobornyl acrylate in the Enlite glucose sensor and the Paradigm MiniMed Quick-set insulin infusion set

Background: The FreeStyle Libre glucose sensor has caused many cases of allergic contact dermatitis, and isobornyl acrylate (IBOA) in this sensor has been identified as one of the culprit allergens. Objectives: To report on the presence of IBOA in devices produced by Medtronic, namely, Enlite sensor and insulin infusion set Paradigm MiniMed Quick-set. Patients and Methods: Five patients reacting t

Agents in early development for treatment of bladder dysfunction–promise of drugs acting at TRP channels?

Introduction: In the lower urinary tract (LUT) several members of the TRP superfamily are involved in nociception and mechanosensory transduction. Animal studies have suggested a therapeutic potential of some of these channels, including TRPV1, TRPV4, TRPM8, TRPA1, and TRPM4, for treatment of bladder over- and underactivity and bladder pain disorders, but translation of this information to clinica

Dynamic changes in DNA methylation during embryonic and postnatal development of an altricial wild bird

DNA methylation could shape phenotypic responses to environmental cues and underlie developmental plasticity. Environmentally induced changes in DNA methylation during development can give rise to stable phenotypic traits and thus affect fitness. In the laboratory, it has been shown that the vertebrate methylome undergoes dynamic reprogramming during development, creating a critical window for env