Filtyp
Telomerase plays an important role in sustaining eukaryotic linear chromosomes, as elongation of telomeres is needed to counterbalance the shortening occurring in each replication round. Nevertheless, in telomerase-deficient cells, Alternative Lengthening of Telomeres (ALT) pathways can maintain telomeres by employing recombination-based mechanisms. In the budding yeast Naumovozyma castellii, effe
A patient with multiple endocrine neoplasia 2A (MEN2A) and a suspicion of metastasized pheochromocytoma, underwent multi-molecular positron emission tomography (PET) imaging with the recently presented radiopharmaceutical [18F]-metafluorobenzylguanidine (mFBG), [68Ga]Ga-DOTA-TOC and [18F]F-dihydroxyphenylalanine (DOPA) as well as scintigraphy with [123I]-metaiodobenzylguanidine (mIBG). The methods
Background: Celiac disease is associated with HLA-risk haplotypes, but non-HLA genes and environmental factors are also linked to disease susceptibility. In this study, we explore the molecular pathways involved in celiac disease by analyzing the differential expression of genes in both the gut and peripheral blood across various celiac disease phenotypes. Methods: Whole genome RNA sequencing was
Black carbon (BC), a major component of fine particulate matter (PM2.5), has been implicated in adverse neurodevelopmental outcomes, including autism spectrum disorders (ASD). While PM2.5 has been associated with increased ASD risk, the specific role of BC remains uncertain. This study aimed to assess prenatal exposure to BC and risk for ASD development in a low exposure setting, using a large, hi
Temperature impacts on microbiological processes are crucial for soil biogeochemistry and ecosystem functioning, yet existing models either fail to capture microbial temperature dependences across the full biokinetic range or risk overparameterization. Here we present the “Dual-Kinetics Ratkowsky” model (Ratkowsky DK), which simultaneously describes temperature dependences of microbial growth and
Background: Monitoring of healthcare quality is typically focused on differences between group averages in relation to a desirable benchmark. However, we need to consider (i) the existence of interconnected socioeconomic axes of inequality like age, sex, income, and country of birth and (ii) individual heterogeneity around group averages. Additionally, (iii) we need clear criteria to quantify grou
Current scholarship on urban transformation emphasizes the importance of learning, but the state of the art of research on learning dynamics in urban transformations is still conceptually and empirically fragmented. To address this deficit, we propose a research agenda and related conceptual apparatus that draws upon previous research in urban transformations and cognate fields. The proposed agend
A text by Gertrud Sandqvist as a response to the work Morning Haze by Oscar Eriksson, exhibited at Galleri Arnstedt in Båstad
The project offers a study of German-Jewish thought by examining Walter Benjamin’s notion of law through the interpretive framework of the Talmud. The widely recognised locus of Benjamin's discussion of law is his essay Toward the Critique of Violence. In his later essays on Kafka, however, Benjamin develops an alternative to the familiar negative notion of law found in the Critique, a development
This article focuses on the structural establishment of Swedish women’s ice hockey during the early 1980s and the years leading up to the first organised women’s hockey league in Sweden. Mainly, the article is based on archive material from The Swedish Ice Hockey Association, especially two committees that were appointed to work to establish women’s hockey between the years of 1981 and 1984: The WThis article focuses on the structural establishment of Swedish women’s icehockey during the early 1980s and the years leading up to the first organisedwomen’s hockey league in Sweden. Mainly, the article is based on archivematerial from The Swedish Ice Hockey Association, especially two committeesthat were appointed to work to establish women’s hockey between the yearsof 1981 and 1984: The Women’
Alpha-synuclein (aSyn) post-translational modifications (PTM), especially phosphorylation at serine 129 and C-terminal truncations, are highly enriched in Lewy bodies (LB), Lewy neurites, and other pathological aggregates in Parkinson’s disease and synucleinopathies. However, the precise role of these PTM in pathology formation, neurodegeneration, and pathology spreading remains unclear. Here, we
Darknet constitutes a part of the internet with a reputation for allowing deviance and criminality. In short, it is often understood as a place where anything goes. Current research on Darknet tends to focus on illicit cryptomarkets, however in this ongoing doctoral research project, I explore how user posts and behaviors are informally and formally controlled and shaped on Darknet forums. Moreove
Jaboticaba (Plinia jaboticaba) is an underutilized Brazilian berry and a source of dietary fiber, cyanidin-3-O-glucoside, and ellagic acid derivatives. Non-clinical studies have shown the potential of jaboticaba to alleviate insulin resistance, low-grade inflammation, and obesity-related cognitive decline, although clinical evidence remains limited. A clinical study was conducted to investigate wh
Digital Transformations of Illicit Drug Markets: Reconfiguration and Continuity is authored by leading experts in the field of illicit drug sourcing, who draw on their interdisciplinary backgrounds to illustrate how modern technologies are embedded within our social structures. Since the digital (r)evolution, the sourcing of illicit drugs now takes place through smartphones, encryption, social med
Comprehensive epigenomic studies in multiple myeloma (MM) that unravel the connections between major epigenetic regulators, their intertwined collaboration and the potential of combinatorial targeting remain limited. Utilizing ChIP-seq, ATAC-seq, RNA-seq, and DNA methylation (DNAme) data, we generated whole-genome chromatin annotations from normal plasma cells and MM patients, revealing epigenomic
