Bispecifika antikroppar bygger broar mellan immunförsvaret och cancerceller – potentiell ny cancerbehandlingsform Prekliniska försök av en ny bispecifik antikropp aktiverar en av immunförsvarets nyckelspelare mot cancerceller från matstrups- och magsäckscancer. Kroppen är utrustad med sitt eget superförsvar, immunsystemet, som varje dag röjer undan olika hot i vår kropp. Det är ett välutvecklaImmune check inhibitors (ICI) are promising tools in the fight against cancer, increasing the effect of Cytotoxic T Lymphocytes (CTL). However, their efficacy can be limited in tumors with poor CTL infiltration or priming, and strategies enhancing this is of great interest. Dual targeting of CD40 on APCs, and a tumor associated antigen (TAA), is one possible approach, promoting tumor-specific CTL

Background: Home care underwent abrupt adaptations to handle the COVID-19 pandemic including an accelerated digitalization. While some research exists regarding the working conditions for home care personnel during the COVID-19 pandemic, few studies exist on the effect of everyday technology use in home care during the pandemic. The aim of this study was to investigate how digital technologies, in

Gaseous ammonia, while influential in atmospheric processes, is critically underrepresented in atmospheric measurements. This limits our understanding of key climate-relevant processes, such as new particle formation, particularly in remote regions. Here, we present highly sensitive, online observations of gaseous ammonia from a coastal site in Antarctica, which allows us to constrain the mechanis

Quantum information science has leaped forward with the exploration of high-dimensional quantum systems, offering greater potential than traditional qubits in quantum communication and quantum computing. To advance the field of high-dimensional quantum technology, a significant effort is underway to progressively enhance the entanglement dimension between two particles. An alternative effective st

Background: In Sweden, dental care for children and adolescents, including specialist orthodontic treatment, is publicly funded. This study aims to analyze the impact of sociodemographic factors on the distribution of publicly funded specialist orthodontic treatment in a mid-sized Swedish region. Methods: A registry-based cohort study was conducted in Region Östergötland, including individuals bor

Introduction: The PI*Mmalton variant is a rare form of alpha-1-antitrypsin (AAT) deficiency, caused by a mutation in the SERPINA1 gene and associated with reduced AAT levels. Its clinical significance remains uncertain due to the limited number of reported cases. Methods: This study characterizes PI*Mmalton carriers within the EARCO (European Alpha-1 Antitrypsin Research Collaboration) registry an

Background: Primary healthcare providers are increasingly challenged in supporting patients with psychosocial needs. Arts on Prescription (AoP) has been shown to improve primary healthcare patients’ mental health wellbeing. The aim of the current study is to understand the psychosocial effect of participating in an Arts on Prescription programme. Methods: A total of 112 primary healthcare patients

We have measured the core-valence double ionization spectra of carbon suboxide above both the O 1s and C 1s edges. Following several core-valence cases known in the literature, to begin with the spectra are compared with the well-known single ionization valence photoelectron spectrum of this system, from which they surprisingly differ quite strongly. This motivates a comparison to electronic struc

Lignans derived from Schisandra chinensis have attracted significant attention for their diverse pharmacological activities and clinical potential. This review presents a comprehensive analysis of the pharmacological properties of Schisandra chinensis lignans, including their antioxidant, anti-inflammatory, neuroprotective, hepatoprotective, antibacterial/viral, antidiabetic and anticancer effects

Marcus Tullius Ciceros verk Brutus, också känt under titeln De claris oratoribus, är en framställning i dialogform av talarkonsten i Rom. Cicero själv har huvudrollen i berättelsen som byggs upp kring Marcus Junius Brutus (den mest namnkunnige av de blivande Caesarmördarna) och Titus Pomponius Atticus (en nära vän till Cicero, från Athen) vilka när de råkar på Cicero ber honom berätta om den romer

The metrology of attosecond pulse trains is based on a cross-correlation technique between a comb of extreme ultraviolet harmonics generated by the high-order harmonic generation process and a synchronised infrared field. The approach, usually referred to as reconstruction of attosecond beating by interference of two-photon transitions (RABBIT), allows one to recover the relative phase between the

To make surgery more precise and to shorten anesthesia-times for children undergoing surgery for Hirschsprung’s disease, ultra-high frequency ultrasound (UHFUS) has been suggested to replace peroperative biopsy. The study’s aim was to determine quantitatively whether aganglionic and ganglionic bowel segments could be distinguished by UHFUS. Bowel specimens of 23 children operated on for rectosigmo

The proliferation of various data sources in urban and territorial environments has significantly facilitated the development of geospatial artificial intelligence (GeoAI) across a wide range of geospatial applications. However, geospatial data, which is inherently linked to geospatial objects, often exhibits data heterogeneity that necessitates specialized fusion and representation strategies whi

In the face of growing criticism of traditional climate adaptation financing mechanisms that often reproduce technocratic approaches and risk entrenching inequalities, this research explores how climate justice, gender equity, and locally-led adaptation can be integrated into adaptation finance in subnational contexts. Analysing case studies from the coastal cities of Cartagena and Buenaventura, i

Perivascular macrophages (PVMs) are a specialized subset of macrophages situated near blood vessels in the brain. Their strategic positioning around these vessels enables them to perform key functions in immune surveillance and response to inflammation and injury. These cells are crucial for modulating the immune response within the brain, contributing to normal central nervous system (CNS) proces