Objective: To determine recent trends in the rate and management of new cases of OA presenting to primary healthcare using UK nationally representative data.Methods: Using the Clinical Practice Research Datalink we identified new cases of diagnosed OA and clinical OA (including OA-relevant peripheral joint pain in those aged over 45 years) using established code lists. For both definitions we esti

OBJECTIVE The circadian clock regulates glucose metabolism by mediating the activity of metabolic enzymes, hormones, and transport systems. Breakfast skipping and night eating have been associated with high HbA1c and postprandial hyperglycemia after lunch and dinner. Our aim was to explore the acute effect of breakfast consumption or omission on glucose homeostasis and clock gene expression in hea

The influence of strong, large-scale magnetic fields on the structure and temperature distribution in white dwarf atmospheres is investigated. Magnetic fields may provide an additional component of pressure support, thus possibly inflating the atmosphere compared to the non-magnetic case. Since the magnetic forces are not isotropic, atmospheric properties may significantly deviate from spherical s

Context. High-precision stellar analyses require hydrodynamic modeling to interpret chemical abundances or oscillation modes. Exoplanet atmosphere studies require stellar background spectra to be known along the transit path while detection of Earth analogs require stellar microvariability to be understood. Hydrodynamic 3D models can be computed for widely different stars but have been tested in d

Elements of sports and physical activity are common in institutional addiction treatment, in both Sweden and other European countries. These activities can be understood as activities of everyday life that promote health and well-being in institutional life. At the same time, physical activity is closely interwoven with a Western culture in which a healthy and fit body is an important social marke

I Abstracts of the XXXVth International Congress on Law and Mental Health

Revised and extended keynote paper presented at the Lund School of Management Conference on Sustainability Reporting and Accountability (SUBREA) November 2016, to appear in a collection ed. by Susanne Arvidsson. There are two scenarios of anti-corruption, one that emphasizes progress generated by the movement, the other, dark side that argues that corruption is still with us, has become more sophi

Background: Recent data imply young patients (age ≤50 years) undergoing small-bowel (SB) capsule endoscopy (CE) for iron deficiency anaemia (IDA) show higher diagnostic yield (DY) for sinister pathology. We aimed to investigate DY of CE in a large cohort of young IDA patients, and evaluate factors predicting significant SB pathology. Materials and methods: This was a retrospective, multicentre stu

Aims The optimal method of tibial component fixation remains uncertain in total knee arthroplasty (TKA). Hydroxyapatite coatings have been applied to improve bone ingrowth in uncemented designs, but may only coat the directly accessible surface. As peri-apatite (PA) is solution deposited, this may increase the coverage of the implant surface and thereby fixation. We assessed the tibial component f

The dose-volume histogram (DVH) is universally used in radiation therapy for its highly efficient way of summarizing three-dimensional dose distributions. An apparent limitation that is inherent to standard histograms is the loss of spatial information, e.g. it is no longer possible to tell where low- and high-dose regions are, and whether they are connected or disjoint. Two methods for overcoming

Aims.: Literature suggests an association between loneliness and mortality for both males and females. Yet, the linkage of loneliness to mortality is not thoroughly examined, and need to be replicated with a long follow-up time. This study assessed the association between loneliness and mortality, including associations to gender, in 1363 adult swedes. Methods.: This community-based prospective co

Background: Long-term oxygen therapy (LTOT) improves prognosis in COPD with severe hypoxemia. However, adherence to criteria for eligibility and quality of LTOT is often insufficient and varies between countries. The aim of this study was to evaluate a national structure for prescription and management of LTOT over three decades in Sweden. Methods: The study was a prospective, population-based stu

OBJECTIVE: To compare access to intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) and its outcomes in patients with and without dementia.METHODS: This was a longitudinal cohort study of the Swedish dementia and stroke registries. Patients with preexisting dementia who had AIS from 2010 to 2014 (n = 1,356) were compared with matched patients without dementia (n = 6,755). We examined ac

About 8000 Swedish women are diagnosed with breast cancer each year, and around 1500 die from the disease. Triple-negative breast cancer (TNBC) constitutes 7-14% of all breast cancer and is characterized by an aggressive phenotype with poor prognosis and no targeted therapy available. The aim of this thesis was to evaluate new potential prognostic biomarkers in breast cancer, and with special focu

Objectives: Occupational exposure to diesel exhaust is common due the widespread use of dieselpowered combustion engines. Diesel exhaust is chemically complex and consists of thousands of compounds present as gases and particulate matter. Both nitrogen dioxide (NO2) and elemental carbon(EC) have been used as markers for diesel exhaust exposure. Currently EC is regarded as the best surrogate of die

Housing politics is a social geographical and ideological battlefield; where housing is seen as a strategic tool and an investment object rather than an essential framework for human lifeworlds. Housing and home is the place where we meet our basic ecological and social needs. A responsible housing politics should therefore not conceive – and instrumentally use – housing as an exclusion mechanism