Purpose of review Severe asthma is a heterogeneous disease that can be classified into phenotypes and endotypes based upon clinical or biological characteristics. Interleukin (IL)-4 and IL-13 play a key role in type 2 (T2) asthma. This article reviews the signaling pathway of IL-4 and IL-13 and highlights its targeted therapy in severe asthma. Recent findings Several clinical trials of biologics t

Aims: This study aims to describe the development of a Cerebral Palsy Follow-up Registry in Jordan (CPUP-Jordan) and to provide a baseline child and parent demographic information, birth history of the child participants, and distribution of the participants based on topographical distribution of cerebral palsy (CP) and functional classification systems. Methods: The CPUP-Jordan was developed usin

Purpose of review There is a clear need for simple and reliable patient-reported outcome measures for chronic obstructive pulmonary disease (COPD) and asthma in daily practice. The purpose of this review is to facilitate the choice for clinicians of patient-reported outcomes which they can use in their daily practice. Recent findings More than 50 patient-reported outcome measures for asthma and CO

Objective: There is a decreased risk of breast cancer in systemic lupus erythematosus (SLE) versus the general population; little is known regarding the receptor status of breast cancers in SLE, or treatment. Methods: Breast cancer cases occurring after SLE diagnosis were ascertained through linkage with tumor registries. We determined breast cancer positivity for estrogen receptors (ER), progeste

Background: The intracranial pressure (ICP) curve with its different peaks has been extensively studied, but the exact physiological mechanisms behind its morphology are still not fully understood. Both intracranial volume change (ΔICV) and transmission of the arterial blood pressure have been proposed to shape the ICP curve. This study tested the hypothesis that the ICP curve correlates to intrac

Aims: Middle Eastern immigrants to western countries are at high risk of developing type 2 diabetes. However, the heritability and impact of first-degree family history (FH) of type 2 diabetes on insulin secretion and action have not been adequately described. Methods: Citizens of Malmö, Sweden, aged 30–75 years born in Iraq or Sweden were invited to participate in this population-based study. Ins

Objective: To investigate the association between serum levels of testosterone and biomarkers of subclinical atherosclerosis based on data from 119 middle-aged men of the general population. Methods: Testosterone, Apolipoprotein A-1 (ApoA-1), Apolipoprotein B (ApoB), Apolipoprotein B-to-Apolipoprotein A-1 ratio (ApoB-to-ApoA-1), high-sensitive C-reactive protein (hsCRP), and fibrinogen levels were

Background: A dysfunctional use of coping strategies has repeatedly been linked to suicidal behaviour in non-psychiatric populations. However, data regarding association between coping strategies and suicidal behaviour in psychiatric populations are limited. Aims: The aim of the study was to investigate the possible relationship between self-reported suicide risk, suicidal ideation and coping stra

Purpose Peripheral T-cell lymphomas (PTCLs) have aggressive clinical behavior. We have previously shown that event-free survival (EFS) at 24 months (EFS24) is a clinically useful end point in diffuse large B-cell lymphoma. Here, we assess EFS24 and subsequent overall survival (OS) in large, multinational PTCL cohorts. Patients and Methods Patients with systemic PTCL newly diagnosed from 2000 to 20

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The bioeconomy has become a central concept in many strategies for future economic development, emphasising an increasing need for collaboration across industries and sectors for innovation. This paper unpacks aspects of collaboration in the bioeconomy by looking at the development of innovation networks for biorefinery technologies from 2004 to 2014 based on innovation project data from Swedish p

Rotor–stator mixers (RSMs) are widely used for emulsification and mixing. However, relatively little is known about the relationship between RSM design, hydrodynamics and performance. Previous studies have investigated shaft power draw as a function of design. However, power draw alone is not sufficient to predict efficiency. In order to understand the effect on performance it is important to inve

The present contribution deals with the development of a laminate-based model designed to study the single and polycrystalline tetragonal ferroelectric material behaviour. Laminate-based models are micromechanically motivated and consider the volume fraction of the distinct ferroelectric variants directly in their formulation. At first, a single crystal laminate-based model is established by consi

Presence of insects in agricultural habitat is affected by the surrounding circumstances such as the complexity and structure of landscape. Landscape structure is often formed as a consequence of the fragmentation of semi-natural habitat, which can negatively affect species richness and abundance of insects. This study was aimed to study the effect of complexity and structure of landscape on the d