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Background/Aim: Circumferential resection margin (CRM) has been shown to be a strong predictor of risk of local recurrence (LR) and distant metastases (DM) in patients with rectal cancer treated with total mesorectal excision (TME). However, not all patients with a CRM of zero develop LR or DM. This study aimed to identify factors associated with disease-free survival (DFS) despite non-radical exc
Purpose: High-risk colon cancer may benefit from preoperative chemotherapy (preCHT), but evidence on its short-term safety and outcome is limited. Population-based evidence before its incorporation into national guidelines is lacking. Methods: Patients with final weighted stage II–III colon cancer undergoing elective resection between 2007 and 2017 were identified in the Swedish Colorectal Cancer
AIM: This retrospective observational cohort study aimed to investigate the prevalence of suspected lateral lymph node metastases (LLNM), as diagnosed by magnetic resonance imaging (MRI), and its impact on local recurrence (LR) and overall survival (OS). Patients who underwent dissection of suspected lymph nodes were evaluated in subgroup analysis.METHOD: Patients diagnosed with rectal cancer in S
Objective To characterize the redistribution patterns of zinc and calcium ions during human sperm capacitation and to investigate their roles in sperm maturation and fertilization. Design In vitro experimental study using synchrotron-based x-ray fluorescence microscopy and complementary immunohistochemistry to assess elemental changes during different capacitation stages at nanometric spatial reso
This is a paper about gymnastics and a primordial form of geological knowledge. It pursues an interpretation of gymnastics, broadly defined, as a philosophy that interrogates what the Earth is. The goal is to reconstruct the epistemic implications of gymnastic practice in order to understand the evolution of animal motility as a prototypical form of geological knowledge. Since gravity is a global
BackgroundHeart failure (HF) and arterial hypertension (AH) are strongly associated with obesity, with a linear relationship to increasing body mass index (BMI). However, some individuals with obesity do not exhibit signs of HF or AH.PurposeThis study aimed to compare, for the first time in a large population-based cohort, individuals with obesity who have normal left ventricular function and remo
Acquired diverticula of the small bowel are mainly located in the duodenum, followed by the jejunum. They are typically asymptomatic, but may occasionally cause massive bleeding, diverticulitis, and even perforation. Meckel’s diverticula are a remnant of the omphalomesenteric duct located in the ileum. They can cause overt bleeding, typically in children, but also in adults. Sensitivity of Meckel’
Benign tumours of the small intestine consist of various rare entities such as tumour-like inflammatory or hyperplastic lesions, hamartomas (organoid malformations), ectopic tissues, and true neoplasms of epithelial or mesenchymal origin. These benign tumours often stay asymptomatic for years, with small lesions frequently remaining undiscovered. They may be manifested clinically by bleeding, iron
This dissertation is about social change ‘and’, ‘with’, as well as ‘through’ food. It examines the rise and expansion of novel approaches to veganism and plant-based lifestyles in the Sino-cultural sphere by foregrounding the assemblage of actors (human and nonhuman) at the forefront of this phenomenon. While East Asia, and more specifically Sinophone societies like China and Taiwan, have long-est
Many theories based on Darwinian evolutionary theory are of particular relevance to family research. The theory of kin selection is not limited to social behavior of animals, but also explains why humans in all cultures and epochs organize their reproductive and productive activities in family networks and family households. Even though the willingness to cooperate in the human family ultimately g
This study investigates the potential of enhancing regional rail efficiency and reducing emissions through the implementation of dual Electric Traction Machine (ETM) drivetrains. By employing two ETMs, optionally with different specifications and real-time load distribution, the research evaluates the impact on energy savings and battery longevity. The analysis is based on a comparative simulation
Objectives: To determine the diagnostic value of disclosing monotypic T-cell populations by expression analysis of the constant region 1 of T-cell receptor β (TRBC1) by flow cytometry, for the detection of T-cell neoplasms, in a routine hematopathology practice setting. Methods: A panel of antibodies ECD-CD16/PECy5.5-CD4/PECy7-CD2/APCAF700-CD7/KO-CD8/FITC-TCRγδ/PE-TRBC1/APC-CD26/APC-CD57/APC-CD30/
BACKGROUND: Evidence indicates that artificial intelligence (AI) can improve mammography screening by increasing cancer detection and reducing screen reading workload, but its effect on interval cancers (primary breast cancers diagnosed between two screening rounds or within 2 years after the last scheduled screening that were not detected at screening) is unknown. We aimed to compare the interval
Objectives: Studies have reported promising results regarding artificial intelligence (AI) as a tool for improved mammographic screening interpretive performance. We analyzed AI malignancy risk scores from two versions of the same commercial AI model. Materials and methods: This retrospective cohort study used data from 117,709 screening examinations performed in BreastScreen Norway 2009–2018. The
Objective: To investigate the dynamic changes of soluble fms-like tyrosine kinase−1 (sFlt−1), placental growth factor (PlGF) and their ratio in maternal plasma, from preeclampsia diagnosis to postpartum, evaluating its clinical utility. Methods: Single-center prospective longitudinal cohort study with repeated sample collection in women with established preeclampsia (PE). Seventy-five (n = 75) wom
The direct conversion of methane to methanol (DCMM) under continuous flow and atmospheric pressure offers notable environmental benefits and industrial promise, but remains a long-standing challenge due to the difficulty of activating CH4while avoiding overoxidation of methanol. Here, we demonstrate that pure ceria (CeO2), without any metal promoters, enables gas-phase DCMM with up to 80% selectiv
Primary care professionals are often the first line of support for children and adolescents with tic disorders. However, families often report feeling inadequately supported and perceive a lack of knowledge about tics. Few studies have examined primary care professionals’ perspectives on managing tic disorders. This study explored how these professionals understood and managed tic disorders in a D
This article presents a Luhmann-inspired theory of conflictualization, that is, how objects, relations, and societies come to be defined by the logic of conflict. This article presents a Galtung- and Luhmann-inspired theory of conflictualization, that is, how objects, relations, and societies come to be defined by the logic of conflict. The article conceptualizes conflictualization as a threefold
