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Reactive oxygen species (ROS)-induced aberrant oncogenic signalling has been proposed to mediate the progression and development of pleural mesothelioma (PM). In this study, we demonstrate how ROS promote oncogenic signalling, especially in the context of cell migration and immune evasion via YB-1 phosphorylation in mesothelial and PM cell models. Xanthine (X)- and xanthine oxidase (XO)-generated
There is a major contradiction between the current model of international elite sport and efforts to mitigate climate change. This study investigates climate action delay discourses within the sports sector by analyzing 28 semi-structured interviews with athletes and sports federation employees. Based on the two climate delay discourse typologies of Lamb et al. (2020, Global Sustainability, 3: e17
Cardiovascular prevention guidelines are based on robust evidence, yet their implementation in primary healthcare remains inconsistent due to systemic barriers, workload pressures and insufficiently adapted tools. The 2025 European consensus emphasizes the need for multidisciplinary teamwork, digital innovation and equity-focused strategies to strengthen prevention across diverse healthcare system
Background: Nocturnal hypoxemia commonly affects people with pulmonary fibrosis (PF). Research Question: What are the current practices for assessment of sleep and nocturnal hypoxemia in PF, and what are the research priorities and outcome measures of importance for nocturnal oxygen therapy (NOT)? Study Design and Methods: People with PF and health care professionals (HCPs) with expertise in PF, s
Objective: To report initial experience using endografts with exclusively retrograde inner branches for endovascular aortic arch repair. Methods: A retrospective review of endovascular aortic arch repairs using custom made endografts exclusively integrating retrograde inner branches (Cook Medical, Brisbane, Australia) was conducted across seven tertiary centres (June 2022 and December 2024). Prima
Background: Emerging evidence suggests that COVID-19 may influence obstructive sleep apnea (OSA) pathophysiology by affecting upper airway collapsibility, ventilatory control, and arousal responses, raising the possibility of a bidirectional relationship. This study examined whether individuals with a history of COVID-19 show altered OSA-related physiological traits compared with those without pri
Background: Ambulatory oxygen therapy is prescribed for patients with chronic lung diseases who experience exertional hypoxemia. However, available devices may not adequately meet user requirements, and their performance characteristics are heterogeneous. Objective: This study aims to identify devices available for delivery of ambulatory oxygen therapy, the technologies that they use to generate o
We discuss two variations of Edwards’ duality theorem. More precisely, we prove one version of the theorem for cones not necessarily containing all constant functions. In particular, we allow the functions in the cone to have a non-empty common zero set. In the second variation, we replace suprema of point evaluations and infima over Jensen measures by suprema of other continuous functionals and i
Context. The Milky Way nuclear star cluster (MWNSC) is located in the Galactic centre, together with the Milky Way nuclear stellar disc (MWNSD), and they dominate the gravitational potential within the inner 300 pc. However, the formation and evolution of the two systems and their possible connections are still under debate. Aims. We reanalysed the low-resolution KMOS spectra in the MWNSC with the
Artificial intelligence (AI) is set to transform the care of women with cancer. From early detection via digital phenotyping to diagnosis, treatment, and follow-up, innovative AI applications are rapidly emerging across the cancer care continuum. AI-assisted mammographic screening for breast cancer has been clinically translated, and AI-based contouring in radiotherapy is streamlining treatment pl
Rates of molecular, phenotypic, and lineage diversification typically scale negatively with time interval of measurement, raising longstanding questions about time-dependency of evolutionary processes. These patterns and their potential meaning have recently re-entered evolutionary discussions. In this Perspective, we revisit the general challenges in interpreting rate–time relationships. Much app
Importance Even within individuals who are amyloid positive, clinical symptoms can be impacted by Alzheimer pathology, other pathologic proteins, and cognitive reserve or resilience. Understanding how each of these factors contributes to a patient’s clinical presentation is crucial for prognosis and treatment decisions in the era of disease-modifying therapies. Objective To evaluate tau-clinical m
Building resilient and sustainable energy systems is a critical challenge for disaster-prone regions in the Global South. This study investigates the energy management of a networked microgrid (NMG) system on Lombok Island, Indonesia, a region frequently exposed to natural disasters (NDs) and characterized by vulnerable grid infrastructure. A multi-objective optimization framework is developed to
Sustainability has received increasing attention in recent years, particularly surrounding concerns of poverty in the Global South, the climate emergency, the loss of biodiversity, and the COVID-19 pandemic. Competition and public authorities are more frequently encountering sustainability questions, while states are more generally called upon to foster sustainability by the UN Resolution 70/1. Ag
It remains unclear how transformative innovation policies can be implemented across various regional contexts. Through policy review, interviews and focus group interviews with key actors, this paper investigates industrial regions’ design and implementation of transformative innovation policies in three Nordic countries. We find that the characteristics of the regional innovation system, unique t
Gastrointestinal (GI) interventional endoscopy has evolved into a cornerstone of modern gastroenterology, offering minimally invasive solutions for complex conditions. However, these procedures are not without risk, particularly with respect to post-procedural infections. While rare, such infections can have significant clinical consequences and are increasingly recognized as a public health conce
A biorefinery can operate with various plant materials as feed stock, (in contrast to fossil-based oil refineries). It has been defined by the International Energy Agency, Task 42, as “the sustainable processing of biomass into a spectrum of marketable bio-based products (chemicals, materials) and bioenergy (biofuels, power, heat)”. One of the challenges in operating large-scale facilities is that
Human papillomavirus (HPV) vaccination may eventually eradicate oncogenic vaccine-targeted HPVs but only with a strategy that also protects unvaccinated individuals. We compared the impact of gender-neutral and girls-only vaccination strategies on the indirect and direct protection of unvaccinated and vaccinated young women against HPV16/18 infection using HPV16/18 seropositivity and PCR positivit
Laila Lalami’s novel The Moor’s Account reclaims the erased historical voice of the Moorish slave Estebanico, one of the first Arab Africans on the American continent in the 1500s. While Lalami explicitly positions her novel as a postcolonial revision of Cabeza de Vaca’s colonial report on the fate of Estebanico, this essay argues that a significant part of the novel’s literary resistance to Arab
This article presents a theoretical framework for deriving simple analytical expressions for spurs resulting from second and third order nonlinearities in fractional-N phase locked loops (PLL). Furthermore, a previously proposed linearization technique where several sigma-delta modulators (SDMs) operate in parallel with relative time offsets between them, is further analyzed using the periodic non
