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The Open Porous Media Flow reservoir simulator

The Open Porous Media (OPM) initiative is a community effort that encourages open innovation and reproducible research for simulation of porous media processes. OPM coordinates collaborative software development, maintains and distributes open-source software and open data sets, and seeks to ensure that these are available under a free license in a long-term perspective. In this paper, we present

Adaptive discontinuous galerkin methods for flow in porous media

We present an adaptive Discontinuous Galerkin discretization for the solution of porous media flow problems. The considered flows are immiscible and incompressible. The fully adaptive approach implemented allows for refinement and coarsening in both the element size, the polynomial degree and the time step size.

A weak compatibility condition for Newest Vertex Bisection in any dimension

We defne a weak compatibility condition for the Newest Vertex Bisection algorithm on simplex grids of any dimension and show that, using this condition, the iterative refnement algorithm terminates successfully. Additionally we provide an O(n) algorithm that renumbers any simplex grid to fulfll this condition. Furthermore we conduct experiments to estimate the distance to the standard compatibilit

RIFM fragrance ingredient safety assessment, glyceryl monooleate, CAS Registry Number 111-03-5

The existing information supports the use of this material as described in this safety assessment. Glyceryl monooleate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that glyceryl monooleate is not genotoxic. Data on glyceryl monooleate provide a cal

Association of Epicardial Fat Volume With the Extent of Coronary Atherosclerosis and Cardiovascular Adverse Events in Asymptomatic Patients With Diabetes

Epicardial adipose tissue has a paracrine effect, enhancing coronary artery atherosclerotic plaque development. This study evaluated epicardial fat volume (EFV), adipokines, coronary atherosclerosis, and adverse cardiovascular events in a cohort of asymptomatic patients with type 2 diabetes mellitus (T2DM). Epicardial fat volume was calculated using data from computed tomography coronary angiogram

Global health policy in the 21st century : Challenges and opportunities to arrest the global disability burden from musculoskeletal health conditions

The profound burden of disease associated with musculoskeletal health conditions is well established. Despite the unequivocal disability burden and personal and societal consequences, relative to other non-communicable diseases (NCDs), system-level responses for musculoskeletal conditions that are commensurate with their burden have been lacking nationally and globally. Health policy priorities an

Determining Rg of IDPs from SAXS Data

There is a great interest within the research community to understand the structure-function relationship for intrinsically disordered proteins (IDPs); however, the heterogeneous distribution of conformations that IDPs can adopt limits the applicability of conventional structural biology methods. Here, scattering techniques, such as small-angle X-ray scattering, can contribute. In this chapter, we

State Segmentation and Democratic Survival in Latin America

Popular models portray that high inequality induces elites to sponsor coups and reverse democratization as a means for repressing redistributive demands. Challenging this prediction, Latin America shifted from a historical pattern of systematic democratic breakdowns to one characterized by the resilience of democracy despite extreme levels of inequality. This article argues that the reminiscence o

Adoption and Diffusion of Disruptive Technologies : The Case of Additive Manufacturing in Medical Technology Industry in Australia

This paper provides the preliminary findings of a newly granted two-year project investigating the adoption of disruptive technologies, by focusing on the case of additive manufacturing (AM) in the medical technology (MedTech) industry, particularly implant applications. This is done by (I) stakeholder mapping of the industry in Australia. This included members of industry, researchers, academics,

Measuring and Analyzing Binding Kinetics of Coupled Folding and Binding Reactions Under Pseudo-First-Order Conditions

Many intrinsically disordered proteins (IDPs) adopt a well-defined structure upon binding to their interaction partners. Kinetic characterization is a requirement for the investigation of the dynamics and mechanisms of these folding-upon-binding reactions. Here a protocol is described for the investigation of binding kinetics of bimolecular binding and folding reactions of IDPs to their ligand par

Maximum extent of the Eurasian ice sheets in the Barents and Kara Sea region during the Weichselian

Based on field investigations in northern Russia and interpretation of offshore seismic data, we have made a preliminary reconstruction of the maximum ice-sheet extent in the Barents and Kara Sea region during the Early/Middle Weichselian and the Late Weichselian. Our investigations indicate that the Barents and Kara ice sheets attained their maximum Weichselian positions in northern Russia prior

Target Tracking using Signal Strength Differences for Long-Range IoT Networks

Radio based positioning or tracking solutions typically require wideband signals or phase coherent antennas. In this paper, we present a target tracking method based on received non-coherent signal strength differences (RSSDs) between antennas for outdoor Internet-of-things (IoT) scenarios. We introduce an RSSD model based on classical path-loss models. With known antenna patterns and antenna arra