BACKGROUND: LINE-1 (L1) retrotransposons are a notable endogenous source of mutagenesis in mammals. Notably, cancer cells can support unusual L1 retrotransposition and L1-associated sequence rearrangement mechanisms following DNA damage. Recent reports suggest that L1 is mobile in epithelial tumours and neural cells but, paradoxically, not in brain cancers.RESULTS: Here, using retrotransposon capt

Transposable elements (TEs) are notable drivers of genetic innovation. Over evolutionary time, TE insertions can supply new promoter, enhancer, and insulator elements to protein-coding genes and establish novel, species-specific gene regulatory networks. Conversely, ongoing TE-driven insertional mutagenesis, nonhomologous recombination, and other potentially deleterious processes can cause sporadi

Human induced pluripotent stem cells (hiPSCs) are capable of unlimited proliferation and can differentiate in vitro to generate derivatives of the three primary germ layers. Genetic and epigenetic abnormalities have been reported by Wissing and colleagues to occur during hiPSC derivation, including mobilization of engineered LINE-1 (L1) retrotransposons. However, incidence and functional impact of

This article analyzes Paul Celan’s translation of James Baldwin’s “Everybody’s Protest Novel” and considers the connections between the poetics of these two writers. In addition to their shared preoccupation with and rearticulation of terms such as human, creature, and darkness, the translation reveals how they explored the relationship between literature and reality at early and transitional mome

Superporous agarose beads were used as an affinity support in column chromatography. These beads characteristically possess two sets of pores, normal diffusion pores and flow pores, so-called superpores. The superpores, whose diameter is a substantial fraction of the particle diameter (i.e. 1/3 to 1/10 of the particle diameter), allow part of the chromatographic flow to pass through each individua

This article centres on Bertha Pappenheim’s translations of Old Yiddish literature, with particular focus on Die Memoiren der Gl€uckel von Hameln, which was published as a private edition in Vienna in 1910. While the fact that Pappenheim translated Glikl’s Yiddish-language writings into German is well known, little attention has been paid to the particular language of the translated text or to Pap

This article reevaluates the circulation and reception of the memoirs of Glikl, an early modern Jewish writer and businesswoman, in the German-speaking world from the mid-19th to the early 20th century. It considers how the text’s modern editors and translators – including Abraham Tendlau, David Kaufmann, Bertha Pappenheim, and Alfred Feilchenfeld – shaped its meaning and determined its value over

Superporous particles contain two sets of pores, normal diffusion pores and very large flow pores. If such particles are used chromatographically, part of the flow will pass through each particle. This leads to a rapid equilibration between the stationary and the mobile phases, even if the superporous particle has a large outer diameter. Superporous particles are thus chromatographically efficient

This dissertation shows how the intersection between German and Yiddish became an important but largely forgotten site of literary production in the long twentieth century. Beginning in the late eighteenth century, German and Yiddish came to be associated with divergent trajectories of Jewish modernity and were often understood to represent either side of a series of charged dichotomies, such as W

This paper reports on a new type of spherical agarose chromatography particles characterized by two sets of pores, normal diffusion pores, characteristic of all agarose materials and very wide pores, so-called superpores or flow pores. These superpores allow part of the chromatographic flow to pass through each individual particle, which gives improved mass transfer, especially in situations where

Numerous studies have reported a correlation between gut microbiota and influenza A virus (IAV) infection and disease severity. However, the causal relationship between these factors remains inadequately explored. This investigation aimed to assess the influence of gut microbiota on susceptibility to human infection with H7N9 avian IAV and the severity of influenza A (H1N1)pdm09 infection. A two-s

E-scooter sharing has been commonly used to integrate public transport systems in many cities worldwide. Accurately modeling integration between shared e-scooters and public transport is important for multi-modal urban transportation development and management. However, the effects of catchment size are scarcely considered while modeling their integration by widely adopting the method based on the

Digital healthcare services and digital health information, here called eHealth services, have the potential to reach people with diverse needs as both a complement to and a substitution for traditional healthcare. The access to and use of digital health information and digital healthcare services that are accessible and usable for people with impairments is a complex phenomenon.This potential is

This paper is based on a study where four go-along interviews with a total of sixteen participants were conducted in three Swedish cities. The purpose of this study was to find out how different aspects and qualities of the built environment affected different persons in terms of experiences of inclusion and exclusion and strategies used to deal with obstacles in the environment. The study highlig

Amid growing concerns about hardware security, comprehensive security testing has become essential for chip certification. This paper proposes a deep-testing method for identifying Trojans of particular concern to middle-to-high-end users, with a focus on illegal instructions. A hidden instruction Trojan can employ a low-probability sequence of normal instructions as a boot sequence, which is foll

Ethnographic insights into people’s working lives can help us envision social policy to build dignified workspaces. This article explores the interlinkages between work and social protection, by drawing attention to two dimensions of pheriwale’s everyday working lives: first, how they relate to their work, and second, how they are situated within the Indian welfare context. Pheriwale are a group o

Introduction Severe osteogenesis imperfecta (OI) is a debilitating disease with no cure or sufficiently effective treatment. Mesenchymal stem cells (MSCs) have good safety profile, show promising effects and can form bone. The Boost Brittle Bones Before Birth (BOOSTB4) trial evaluates administration of allogeneic expanded human first trimester fetal liver MSCs (BOOST cells) for OI type 3 or severe

Semiconductor technology constantly advances, enabling integrated circuits (ICs) with increasingly numerous, faster, and smaller transistors. While this progress offers many benefits, it also presents new challenges, such as tighter margins, wear-outs, and process variations. To effectively tackle these challenges, the conventional approach of using external test instruments during manufacturing t