Colon cancer is among the most lethal and prevalent malignant tumors in the world, and the lack of effective therapies highlights the need for novel therapeutic approaches. Schisandrin B (Sch B), a lignan extracted from the fruit ofSchisandra chinensis, has been reported for its anticancer properties. However, to date, no studies have been done to characterize the exact molecular mechanisms underl

Background: Increasing trends of oxidized linalool contact allergy have been reported. However, the impact of reactivity and dose in eliciting allergic contact dermatitis caused by linalool hydroperoxides is insufficiently investigated. Objectives: To perform repeated open application tests (ROATs) using the real-world concentrations of linalool hydroperoxides in patients and control participants.

A radical transformation of the transport industry is required in order to achieve a fossil-fuel-free vehicle fleet and reach the greenhouse gas emissions goals. Electrification plays a crucial role in this radical process. An electric road system (ERS) is a road that supplies power to electric vehicles as they drive on it, offering numerous advantages. These include an extended driving range, dec

Myocardial infarction is a leading cause of death globally but is notoriously difficult to predict. We aimed to identify biomarkers of an imminent first myocardial infarction and design relevant prediction models. Here, we constructed a new case–cohort consortium of 2,018 persons without prior cardiovascular disease from six European cohorts, among whom 420 developed a first myocardial infarction

This paper presents an experimental study where the mechanical behaviour of single-dowel timber connections made of acetylated Scots pine is compared with the behaviour of connections made from untreated Scots pine. The main aim was to evaluate the influence of the acetylation on the connection brittleness and also to compare the experimental results to the design provisions of the current Europea

The aim of this study was to add knowledge of the longitudinal associations between gaming and emotional closeness between parents and their children. We hypothesized that parent–child emotional closeness was linked to less gaming activity over time and that more gaming activity was linked to less parent–child emotional closeness over time. We also tested the moderating effect of child gender on t

This thesis comprises four self-contained papers that rely on applied micro-econometric methods to understand which factors are important in shaping the gender wage gap in globalized firms and how firms innovate when exposed to trade-induced shocks. In the first paper, we study how the within-firm gender wage gap in Sweden is affected by the degree of gender inequality in the home country of forei

This article examines how foreign policy branding is legitimated as a response to human rights crises. Drawing on legitimation theory (van Leeuwen, 2007), this study takes a discourse perspective with a focus on the enactment of foreign policy in communication and argues that legitimacy is the foundation for constructing a convincing and credible image of a country and its foreign policy. Building

In this study, the duality of adaptive capacity in aviation safety is examined, where the need for resilience of frontline workers conflicts with the expectations and assumptions of upstream entities, leading to system brittleness. We explore three critical categories: responsibilization, the application of practical wisdom in navigating challenging situations, and the unrecognized sacrifices that

The vector-boson production cross section for the Higgs boson decay in the Formula Presented channel is measured as a function of kinematic observables sensitive to the Higgs boson production and decay properties as well as integrated in a fiducial phase space. The analysis is performed using the proton-proton collision data collected by the ATLAS detector in Run 2 of the LHC at Formula Presented

We propose a notion of Misiurewicz condition for transcendental entire functions and study perturbations of Speiser functions satisfying this condition in their parameter spaces (in the sense of Eremenko and Lyubich). We show that every Misiurewicz entire function can be approximated by hyperbolic maps in the same parameter space. Moreover, Misiurewicz functions are Lebesgue density points of hype

This letter presents a measurement of the nuclear modification factor of large-radius jets in Formula Presented Formula Presented collisions by the ATLAS experiment. The measurement is performed using Formula Presented and Formula Presented of Formula Presented and Formula Presented data, respectively. The large-radius jets are reconstructed with the anti-Formula Presented algorithm using a radius

This systematic review captures research on doctoral students’ perspectives of supervision. The aim was to capture research on aspects of importance to enhance professional development for supervisors in a global perspective, as well as describe the characteristics of the body of research. Five aspects of supervisors’ competences, which have previously been found to be important for successful sup

Exclusion zones in the cross-correlations between critical points (peak-void, peak-wall, filament-wall, and filament-void) of the density field define quasi-standard rulers that can be used to constrain dark matter and dark energy cosmological parameters. The average size of the exclusion zone is found to scale linearly with the typical distance between extrema. The latter changes as a function of

Middle managers often find themselves in a challenging position: They have to impress different audiences in somewhat incompatible ways and represent and enact managerial ideals and expectations that may be detrimental to their work identities. This study explores role distancing as an alluring coping strategy. Role distancing – acts that express separateness between the individual and the enacted

Aim: To increase survival in out-of-hospital cardiac arrests (OHCA), great efforts are made to improve the number of voluntary first responders (VFR). However, evidence of the potential utility of such efforts is sparse, especially in rural areas. Therefore, the aim was to describe and compare response times for emergency medical services (EMS), fire and rescue services (FRS), and VFR during OHCA