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Two-dimensional (2D) culturing of cancer cells has been indispensable for the development of anti-cancer drugs. Drug development, however, is lengthy and costly with a high attrition rate, calling to mind that 2D culturing does not mimic the three-dimensional (3D) tumour microenvironment in vivo. Thus, began the development of 3D culture models for cancer research. We have constructed a 3D 96-well

This paper is a comparison of water vapor resistance (Ret) measured using the Permetest skin model and Tore sweating thermal manikin, i.e. 2D versus 3D methods; and to study the relationship between them. Three materials and five air gap distances were used for the measurement between these two devices, the test conditions in the climatic chambers were set up according to the ISO standard of each

Across Asia, the international school scene has experienced marketisation and corporatisation. A consequence is that many wealthier families–outside of expatriate communities–view international schools as a desirable choice, and they seek ways to enrol their children in international schools. States have responded to this situation through policies that manage the boundaries between public or nati

This chapter examines the aesthetic of the sinograph in the French-language novels, calligraphic works, and picture books by two first-generation Chinese migrant writers and artists in France, François Cheng and Shan Sa. It begins with an illustration of Cheng's and Shan's 'Chinese' calligraphic works (accompanied by the artists' French texts) (Et le Souffle devient signe: Portrait d’une âme à l’e

Francophone Chinese writers Dai Sijie and François Cheng are both first-generation migrants in France, whose French-language literary works have received the highest French institutional recognitions (from the Prix Femina to the Grand Prix de la francophonie de l'Académie française). Existing scholarship on the impact of their native Chinese language on these writers' French texts focuses almost e

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies and is known for its high resistance and low response to treatment. Tumor immune evasion is a major stumbling block in designing effective anticancer therapeutic strategies. Karyopherin alpha 2 (KPNA2), a member of the nuclear transporter family, is elevated in multiple human cancers and accelerates carcinogenesis. Howeve

Healthcare in Sweden is dealing with problems regarding accessibility for patients. Moreover, there is a lack of an overall model concerning matching specialist care to patients. Against this background, the purpose was to develop a preliminary healthcare matching model and discuss the barriers of this model. Theoretically, the study draws on the concepts of matching and coordination completed wit

Systembolaget kan genom sin monopolställning låta storsäljarna finansiera det udda utbudet, det lokala utbudet, personalens kompetens och ett stort samhällsansvar. Denna affärsmodell skulle med fördel till exempel kunna föras över till detaljhandel med fisk och skaldjur.