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METTL13 (also known as eEF1A‐KNMT and FEAT) is a dual methyltransferase reported to target the N‐terminus and Lys55 in the eukaryotic translation elongation factor 1 alpha (eEF1A). METTL13‐mediated methylation of eEF1A has functional consequences related to translation dynamics and include altered rate of global protein synthesis and translation of specific codons. Aberrant regulation of METTL13 h
Over the last couple of years both cameras, audio and radio sensors have become cheaper and more common in our everyday lives. Such sensors can be used to create maps of where the sensors are positioned and the appearance of the surroundings. For sound and radio, the process of estimating the sender and receiver positions from time of arrival (TOA) or time-difference of arrival (TDOA) measurements
To provide retrospective, descriptive information on patients with cervical necrotizing fasciitis treated at a single center during the years 1998-2014, and to evaluate the outcome of a newly introduced treatment strategy. Retrospective analysis of clinical data obtained from medical records. Mortality, pre-morbidity, severity of illness, primary site of infection, type of bacteria, time parameter
NAA10 is a major N-terminal acetyltransferase (NAT) that catalyzes the cotranslational N-terminal (Nt-) acetylation of 40% of the human proteome. Several reports of lysine acetyltransferase (KAT) activity by NAA10 exist, but others have not been able to find any NAA10-derived KAT activity, the latter of which is supported by structural studies. The KAT activity of NAA10 towards hypoxia-inducible f
Active galactic nuclei (AGNs) are very powerful galaxies characterized by extremely bright emissions coming from their central massive black holes. Knowing the redshifts of AGNs provides us with an opportunity to determine their distance to investigate important astrophysical problems, such as the evolution of the early stars and their formation, along with the structure of early galaxies. The red
The transverse momentum (pT) differential cross section of the charm-strange baryon Ξc0 is measured at midrapidity (|y| < 0.5) via its semileptonic decay into e+Ξ−νe in pp collisions at s = 5.02 TeV with the ALICE detector at the LHC. The ratio of the pT-differential Ξc0-baryon and D0-meson production cross sections is also reported. The measurements are compared with simulations with different tu
Measurements of elliptic (v2) and triangular (v3) flow coefficients of π±, K±, p+p ¯ , KS0, and Λ+Λ ¯ obtained with the scalar product method in Xe-Xe collisions at sNN = 5.44 TeV are presented. The results are obtained in the rapidity range |y| < 0.5 and reported as a function of transverse momentum, pT, for several collision centrality classes. The flow coefficients exhibit a particle mass depen
Two-particle Azimuthal correlations are measured with the ALICE apparatus in pp collisions at s=13 TeV to explore strangeness- and multiplicity-related effects in the fragmentation of jets and the transition regime between bulk and hard production, probed with the condition that a strange meson (KS0) or baryon (Λ) with transverse momentum pT> 3 GeV/c is produced. Azimuthal correlations between kao
The method of shooting and bouncing rays (SBR) was originally developed for radar cross section (RCS) analysis of aircraft engines, but is today widely used in many applications requiring high-frequency approximations. A dense grid of ray-tubes are launched from the source and traced by the laws of geometrical optics (GO) until they reach a defined exit aperture, from which the far field contribut
The past and present distribution of Lobaria pulmonaria in Denmark, northern Germany, northwestern Poland and nemoral parts of Skåne, Blekinge, southwesternmost Småland and southern Öland (Sweden) has been studied. Of 124 localities visited between 2015 and 2018, L. pulmonaria was confirmed at 64 sites, at each of which its habitat ecology and viability were investigated. It is almost extinct in S
BACKGROUND: Although coronary events (CE) and ischemic stroke share many risk factors, there are also some important differences. The aim of this paper was to assess the association of risk factors in relation to incident CE and ischemic stroke and to evaluate the heterogeneity in patterns of risk factors between the two outcomes.METHOD: Traditional risk factors and inflammatory markers associated
Transitioning into a sustainable energy system is becoming ever more pressing as the reality of an anthropogenic ecological crisis becomes difficult to ignore. Due to the complexity of the matter, proposed solutions often address the symptoms of the current socioeconomic configuration rather than its core. To conceptualise possible future energy systems, this Perspective focuses on the disconn
Natural and synthetic sugars have great potential for developing highly biocompatible and translatable chemical exchange saturation transfer (CEST) MRI contrast agents. In this study, we aimed to develop the smallest clinically available form of dextran, Dex1 (molecular weight, MW ~ 1 kDa), as a new CEST agent. We first characterized the CEST properties of Dex1 in vitro at 11.7 T and showed that t
This paper provides a theoretical model that captures the essential features of a Swedish health care reform where private and public health care providers serve patients with certain functional impairments, but where only private providers can reject service requests from patients. Since the hourly price compensation is fixed, this type of systems is expected to result in a monetary deficit for p
In this article, we propose a new estimator of panel data models with interactive fixed effects and multiple structural breaks that is suitable when the number of time periods, T, is fixed and only the number of cross-sectional units, N, is large. This is done by viewing the determination of the breaks as a shrinkage problem, and to estimate both the regression coefficients, and the number of brea
This paper presents an approach for optimizing floor plans using data collected from workplaces and a physics-based planning algorithm utilizing GPU-acceleration. The approach is compared to two approaches based on Genetic Algorithms and Particle Swarm Optimization. Common objectives, such as minimizing distance between related departments and daylight usage are optimized using the physics-based m
This paper investigates the FPGA resources for the implementation of in-cycle closed-loop combustion control algorithms. Closed-loop combustion control obtains feedback from fast in-cylinder pressure measurements for accurate and reliable information about the combustion progress, synchronized with the flywheel encoder. In-cycle combustion control requires accurate and fast computations for their
This paper performs a numerical study regarding the effects of different kinds of coolants on flow and heat transfer in a pin-finned internal channel. A new pin-fin structure detached from one endwall with a round-tip is proposed which aims to increase the heat transfer enhancement. As a contrast, the investigation of the typical fully-attached pin-fin and the flat-tip detached pin-fin is also con
