Effects of hypoxia on activity of primary human lung fibroblast from COPD patients
Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung disease without curable treatment. COPD is divided into stages of increasing disease severity GOLD I – IV, with GOLD IV being most severe. Pathophysiological changes in COPD include chronic pulmonary inflammation, irreversible small airway remodelling and emphysema and found to be driven by hypoxia, inflammation and oxidative str
