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Adult hippocampal neurogenesis is strongly impaired in Alzheimer's disease (AD). In several mouse models of AD, it was shown that adult-born neurons exhibit reduced survival and altered synaptic integration due to a severe lack of dendritic spines. In the present work, using the APPxPS1 mouse model of AD, we reveal that this reduced number of spines is concomitant of a marked deficit in their neur

Comparative empirical studies of the link between economic growth, carbon emissions and ecological footprints (e.g. Fritz and Koch 2016) suggest that current Western production and consumption patterns and welfare standards are incompatible with environmental limits and IPCC climate targets. In the absence of evidence for absolute decoupling of economic growth, material resource input and carbon e

One of the conclusions from comparative empirical studies of the structural challenges towards making global production and consumption patterns compatible with environmental limits is that rich countries would need to ‘degrow’ (O’Neill 2015; Fritz and Koch 2016). To shed light on the potential role of the state in such a planned downscaling process the paper compares state roles in a capitalist e

We are developing a new technique to apply transition-edge sensors (TESs) to X-ray spectroscopy of exotic atoms, especially of kaonic atoms. To demonstrate the feasibility of this pioneering project, performance of a TES-based X-ray detector was evaluated in pion- and kaon-beam environments at particle accelerators.We successfully observed X-rays from pionic-carbon atoms with a resolution as good

Composite films were sprayed from mixtures of water soluble hydroxypropyl methylcellulose (HPMC) and either nanofibrillated cellulose (NFC) or cellulose nanocrystals (CNC). Fiber diameter was similar for both nanocelluloses but fiber length was several μm for NFC and about 200 nm for CNC. Films were characterized for morphology, swelling, mass loss and transport properties. NFC-HPMC films swelled

Obesity impairs the relaxant capacity of adipose tissue surrounding the vasculature (PVAT) and has been implicated in resultant obesity-related hypertension and impaired glucose intolerance. Resident immune cells are thought to regulate adipocyte activity. We investigated the role of eosinophils in mediating normal PVAT function. Healthy PVAT elicits an anti-contractile effect, which was lost in m

Key message: Pru p 3, a peach LTP, is located in pollinated flower styles and secreting downy hairs, transporting a derivative of camptothecin bound to phytosphingosine. Pru p 3 may inhibit a second pollination and may keep away herbivores until seed maturation. Abstract: The allergen Pru p 3, a peach lipid transfer protein, has been well studied. However, its physiological function remains to be

Municipal wastewater treatment commonly involves mechanical, biological and chemical treatment steps to protect humans and the environment from adverse effects. Membrane technology has gained increasing attention as an alternative to conventional wastewater treatment due to increased urbanization. Among the available membrane technologies, microfiltration (MF) and forward osmosis (FO) have been se

Reducing levels of the aggregation-prone Aβ peptide that accumulates in the brain with Alzheimer's disease (AD) has been a major target of experimental therapies. An alternative approach may be to stabilize the physiological conformation of Aβ. To date, the physiological state of Aβ in brain remains unclear, since the available methods used to process brain tissue for determination of Aβ aggregate

A large number of human diseases are caused by chronic tissue injury with fibrosis potentially leading to organ failure. There is a need for more effective anti-fibrotic therapies. Congenital muscular dystrophy type 1A (MDC1A) is a devastating form of muscular dystrophy caused by laminin α2 chaindeficiency. It is characterized with early inflammation and build-up of fibrotic lesions, both in patie

In pristine Sphagnum-dominated peatlands, (di)nitrogen (N2) fixing (diazotrophic) microbial communities associated with Sphagnum mosses contribute substantially to the total nitrogen input, increasing carbon sequestration. The rates of symbiotic nitrogen fixation reported for Sphagnum peatlands, are, however, highly variable, and experimental work on regulating factors that can mechanistically exp

Vad är en kompetensportfölj? En samling arbetsprover som visar upp den egna kompetensen? En elektronisk plattform för dokumentlagring? En övning i reflektion och utveckling? I denna rapport samlas erfarenheter från medarbetare vid Lunds universitet som under perioden 2015–2016 har arbetat med kompetensportföljer – för studenter och lärare. Rapporten redovisar resultat från tre delprojekt: • Utveck

Stroke is the leading cause of disability in developed countries and among the major causes of death worldwide. During a stroke, neurons deprived of their normal metabolic substrates cease to function in seconds and show signs of structural damage after only a few minutes which result in the impairment of sensory and motor function. Loss of function after stroke is due to neuronal death and irreve

Under de senaste åren har en doktorand ockuperat den akademiska ledningscentralen och skisserat ett antal renoveringar med mål att förändra premisserna för arbetet med breddad rekrytering av studenter från studieovana hem. Utgångpunkten för renoveringarna är att rikta blicken mot de villkor och strukturer, som ’de studieovana’ möter och istället för att fokusera på hur ’De’ ska anpassas till ’Oss’Over the past few years a Ph.D. student has occupied the academic command centre and sketched a number of renovations in order to change the university’s ongoing work to broaden the recruitment of students from homes with no study habit. The point of departure of the renovations is to direct attention to the terms and structures that people with backgrounds different than the academic norm are sup

Phase diagrams are useful tools to study the phase equilibria of nanowire materials systems because the growth of nanowires is accompanied by phase formation and phase transition. We have modeled the phase equilibria of the As-Au-Ga ternary system by means of the CALPHAD method. This method is a well-established semi-empirical technique for thermodynamic modeling in which Gibbs energy functions wi

A grating compressor is characterized using the dispersion scan technique and a reference piece of glass. The procedure yields both the spectral phase of the ultrashort pulses and the dispersion of the compressor itself.

The harm that pathogens cause to hosts during infection, termed virulence, varies across species from negligible to a high likelihood of rapid death. Classic theory for the evolution of virulence is based on a trade-off between pathogen growth, transmission and host survival, which predicts that higher within-host growth causes increased transmission and higher virulence. However, using data from

A general scaling formalism for nonlinear light-matter interactions in gases is presented and experimentally verified. The formalism enables to conveniently extrapolate nonlinear phenomena, such as filamentation or high-order harmonic generation, to new laser parameters.