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Earth System Governance in Africa: knowledge and capacity needs

Traditional approaches for understanding environmental governance - such as environmental policy analysis or natural resources management - do not adequately address the gamut of human-natural system interactions within the context of the complex biogeophysical cycles and processes of the planet. This is perhaps more so in the African regional context where the complex relationships between modern

A significant component of ageing (DNA damage) is reflected in fading breeding colors: an experimental test using innate antioxidant mimetics in painted dragon lizards

A decade ahead of their time, von Schantz et al. united sexual selection and free radical biology by identifying causal links between deep-rooted physiological processes that dictate resistance to toxic waste from oxidative metabolism (reactive oxygen species, ROS), and phenotypic traits, such as ornaments. Ten years later, these ideas have still only been tested with indirect estimates of free ra

A theoretical study of diffusional transport over the alveolar surfactant layer.

In this communication, we analyse the passage of oxygen and carbon dioxide over the respiratory membrane. The lung surfactant membrane at the alveolar interface can have a very special arrangement, which affects the diffusional transport. We present a theoretical model for the diffusion of small molecules in membranes with a complex structure, and we specifically compare a membrane composed of a t

SDI planning using the system dynamics technique within a community of practice: lessons learnt from Tanzania

There exist major challenges in accelerating the spatial data infrastructure (SDI) planning process in the developing countries as well as advocating for politicians to support the development of SDI, due to the high complexity of SDI, lack of knowledge and experience, and limited insight in the benefits. To address these challenges, a methodology for SDI planning in Tanzania, based on the system

A cathodoluminescence study of the influence of the seed particle preparation method on the optical properties of GaAs nanowires.

Cathodoluminescence at 8 K is used to compare the optical properties of AlGaAs-capped GaAs nanowires, grown by metal-organic vapour phase epitaxy and seeded by gold particles prepared by different methods. Six different methods were used to fabricate and deposit gold seed particles onto GaAs substrates: colloid particles, aerosol particles and particles defined by electron beam lithography. The na

Order-Disorder Transition of Nonionic Onions under Shear Flow

We have investigated the shear-induced ordering of multilamellar vesicles (onions) in a nonionic surfactant (C12E4) system using a small-angle light scattering (shear-SALS) and a small-angle X-ray scattering (shear-SAXS) technique. In a narrow shear rate-temperature space, the onions form a two-dimensional (2D) hexagonally close-packed structure that shows characteristic hexagonal scattering patte

Long-term prognosis of early-onset breast cancer in a population-based cohort with a known BRCA1/2 mutation status.

All women in the South Sweden Health Care Region with breast cancer diagnosed aged less than 41 during the period between 1990 and 1995 were contacted in 1996 and offered germline mutation analysis of the BRCA1 and BRCA2 genes. Mutation carriers (n = 20) were compared with noncarriers (n = 201) for overall survival (OS) and risk of contralateral breast cancer (CBC). Mutation carriers were younger

Norovirus Genotypes in Hospital Settings - Differences between Nosocomial and Community-Acquired Infections.

Norovirus is a major cause of gastroenteritis and hospital outbreaks, leading to substantial morbidity and direct healthcare expenses as well as indirect societal costs. The aim of the study was to estimate the proportion of nosocomial norovirus infections among inpatients tested positive for norovirus in Denmark, 2002-2010, and to study the distribution of norovirus genotypes among inpatients wit

Agricultural pest monitoring using fluorescence lidar techniques – Feasibility study

The fluorescence of different types of planthopper (Hemiptera) and moth (Lepidoptera), which constitute important Chinese agricultural pests, was investigated both in situ in a laboratory setting and remotely using a fluorescence light detection and ranging (lidar) system operating at a range of about 50 m. The natural autofluorescence of different species, as well as the fluorescence from insects

A massive expansion of effector genes underlies gall-formation in the wheat pest Mayetiola destructor

Gall-forming arthropods are highly specialized herbivores that, in combination with their hosts, produce extended phenotypes with unique morphologies [1]. Many are economically important, and others have improved our understanding of ecology and adaptive radiation [2]. However, the mechanisms that these arthropods use to induce plant galls are poorly understood. We sequenced the genome of the Hess

Successful change of treatment strategy in elderly patients with primary central nervous system lymphoma by de-escalating induction and introducing temozolomide maintenance: results from a phase 2 study by The Nordic Lymphoma Group.

Background: Nordic Lymphoma Group has conducted a phase ll trial in primary central nervous system lymphoma patients applying age-adjusted multi-agent immunochemotherapy regimen, which in elderly patients included temozolomide maintenance treatment. Design and Methods: Patients with newly diagnosed PCNSL aged 18-75 years were eligible. Sixty-six patients (median age 64 years) were enrolled. Two ag

Investigation into the Feasibility of Thioditaloside as a Novel Scaffold for Galectin-3-Specific Inhibitors

Galectin-3 is extensively involved in metabolic and disease processes, such as cancer metastasis, thus giving impetus for the design of specific inhibitors targeting this -galactose-binding protein. Thiodigalactoside (TDG) presents a scaffold for construction of galectin inhibitors, and its inhibition of galectin-1 has already demonstrated beneficial effects as an adjuvant with vaccine immunothera

Questioning the discriminatory accuracy of broad migrant categories in public health: self-rated health in Sweden

BACKGROUND: Differences between natives and migrants in average risk for poor self-rated health (SRH) are well documented, which has lent support to proposals for interventions targeting disadvantaged minority groups. However, such proposals are based on measures of association that neglect individual heterogeneity around group averages and thereby the discriminatory accuracy (DA) of the categori

Clinical translation of stem cell transplantation in Parkinson's disease.

In Parkinson's disease (PD), the main pathology underlying the motor symptoms is a loss of nigrostriatal dopaminergic neurons. Clinical trials of intrastriatal transplantation of human foetal mesencephalic tissue have shown that the grafted dopaminergic neurons re-innervate the striatum, restore striatal dopamine release and, in some cases, induce major, long-lasting improvement of motor function.