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Because of the vital roles of industry in sustainable development, it is essentialthat environmental management is effective in preventing pollution. To this end,environmental management systems have been implemented to a growing extent inindustry. Moreover, this Ph.D. research has demonstrated that environmentalmanagement efforts must be systematic to use environmental performanceindicators effec
In this work, we consider the problem of multi-pitch estimation using sparse heuristics and convex modeling. In general, this is a difficult non-linear optimization problem, as the frequencies belonging to one pitch often overlap the frequencies belonging to other pitches, thereby causing ambiguity between pitches with similar frequency content. The problem is further complicated by the fact that
This paper explores how noblemen expressed themselves in late-medieval Scandinavian castles, in the buildings and in the landscape. The focus is on decorated stone tablets with coats of arms and memorial texts found on the castle walls, but the landscape setting of the castles is also discussed. The examples considered here are Glimmingehus in Scania, in present-day southern Sweden, and Olofsborg
Interventions for preventing falls in older people often involve several components, multidisciplinary teams, and implementation in a variety of settings. We have developed a classification system (taxonomy) to describe interventions used to prevent falls in older people, with the aim of improving the design and reporting of clinical trials of fall-prevention interventions, and synthesis of eviden
Purpose: To establish predictive models for late objective aspiration and late patient-reported choking based on dose-volume parameters and baseline patient and treatment characteristics, for patients with head and neck cancer undergoing definitive radiotherapy (RT). The impact of electively treated volume on late aspiration was also investigated. Methods and material: This prospective cohort is a
The response of the terrestrial water cycle to global warming is central to issues including water resources, agriculture and ecosystem health. Recent studies indicate that aridity, defined in terms of atmospheric supply (precipitation, P) and demand (potential evapotranspiration, E p) of water at the land surface, will increase globally in a warmer world. Recently proposed mechanisms for this res
Introduction: Few large studies have examined the heritability of venous thromboembolism (VTE). Moreover, twin studies have been suggested to overestimate heritability. The aim of the present study was to determine the heritability nationwide in the general Swedish population using full siblings and half-siblings. Methods: VTE was defined using the Swedish patient register. Full sibling (FS) and h
Half the global soil carbon (C) is held in high-latitude systems. Climate change will expose these to warming and a shift towards plant communities with more labile C input. Labile C can also increase the rate of loss of native soil organic matter (SOM); a phenomenon termed ‘priming’. We investigated how warming (+1.1 °C over ambient using open top chambers) and litter addition (90 g m−2 yr−1) tre
Event-Shape Engineering (ESE) is a tool that enables some control of the initial geometry in heavy-ion collisions in a similar way as the centrality enables some control of the number of participants. Utilizing ESE, the path length in and out-of plane can be varied while keeping the medium properties (centrality) fixed. In this proceeding it is argued that this provides additional experimental inf
Local delivery of amyloid beta oligomers from the tip of a nanopipette, controlled over the cell surface, has been used to deliver physiological picomolar oligomer concentrations to primary astrocytes or neurons. Calcium influx was observed when as few as 2000 oligomers were delivered to the cell surface. When the dosing of oligomers was stopped the intracellular calcium returned to basal levels o
UNLABELLED: Persistent CB1 cannabinoid receptor activity limits neurotransmitter release at various synapses throughout the brain. However, it is not fully understood how constitutively active CB1 receptors, tonic endocannabinoid signaling, and its regulation by multiple serine hydrolases contribute to the synapse-specific calibration of neurotransmitter release probability. To address this questi
A major challenge in neuroscience is to determine the nanoscale position and quantity of signaling molecules in a cell type- and subcellular compartment-specific manner. We developed a new approach to this problem by combining cell-specific physiological and anatomical characterization with super-resolution imaging and studied the molecular and structural parameters shaping the physiological prope
Interparticle forces in granular materials are intimately linked to mechanical properties and are known to self-organize into heterogeneous structures, or force chains, under external load. Despite progress in understanding the statistics and spatial distribution of interparticle forces in recent decades, a systematic method for measuring forces in opaque, three-dimensional (3D), frictional, stiff
Purpose: In Gaucher disease, diminished activity of the lysosomal enzyme, acid β-glucosidase, leads to accumulation of glucosylceramides and related substrates, primarily in the spleen, liver, and bone marrow. Eliglustat is an oral substrate reduction therapy approved in the European Union and the United States as a first-line treatment for adults with type 1 Gaucher disease who have compatible CY
