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Aims: Fetal insulin is a key regulator of fetal growth and the major contributor to high birth weight in pregnancies with maternal diabetes. There is evidence for genetic variation in regulating fetal insulin, but this has not been studied on a large-scale. We performed a genome-wide association study (GWAS) of umbilical cord insulin and c-peptide measurements to identify genetic variants associat
This chapter presents a case study of artistic data collection within a project at the intersection of opera, technology, and embodied cognition. The collaborative process in the research project First Person Singer provided an opportunity to examine how artistic and scientific practices can create shared spaces for mutual exchange. It demonstrates how a single dataset may simultaneously serve as
To persuade creditors to lend, cities in the Low Countries relied on a community responsibility system that made all citizens personally liable for public debt. This exposed itinerant citizens to significant risks: their merchandise could be confiscated by creditors, and they could even be imprisoned for debt. Although it is usually difficult to assess how such sanctions were enforced in practice,
Recent advances in vibrational spectroscopy techniques have proven to be reliable, fast and operator-independent tools for extracellular vesicles (EVs) study. In an attempt to further reveal the wide potential that the vibrational spectroscopy can achieve in EV characterization, in the present study we analysed the EVs isolated from various cell lines employing Attenuated Total Reflectance Fourier
Background: Effectively identifying individuals exposed to drug underuse, overuse and potentially inappropriate medication (PIM) in older adults is essential for minimizing preventable drug-related harms. Methods: We analysed data from 54,296 individuals aged 60–74 years from the German National Cohort (NAKO). We assessed the frequency of PIM, untreated conditions (medication and vaccination under
Background: Increasing evidence suggests that total metabolic tumor volume (tMTV) measured before treatment in lymphoma patients undergoing [18F]fluorodeoxyglucose (FDG) PET/CT scans can predict prognosis. However, there is a lack of fast, reliable, and easy-to-perform multilesional segmentation tools with an urgent need to improve tMTV segmentation workflow in clinical practice. Here, we develop
Objective Menopausal transition, brings significant changes to various aspects of health and well-being, including sexuality. These changes are influenced by hormonal changes, psychological factors, and societal perceptions. Historically, research on menopausal transition has predominantly focused on pharmacological treatments, to address symptoms. However, these studies often neglect the inclusio
Background: Peptic ulcer disease (PUD) is characterized by an ulcer in the gastric or duodenal mucosa, approximately 3–5 mm deep. This global health concern significantly impacts health and quality of life, necessitating increased public awareness for the prevention and control of its risk factors. Materials and Methods: The study employed a cross-sectional online questionnaire targeting 400 adult
Integrins are transmembrane glycoproteins that act as essential adhesion receptors, allowing cells to communicate with the extracellular matrix (ECM). This interaction not only helps cells regulate adhesion, but also transmits signals that guide a variety of cellular processes. Once bound to the ECM, integrins play an important role in the cell differentiation, migration, proliferation, and surviv
This study examines how Instagram’s platformized ecosystem shapes imaginaries of #sustainableconsumption. Using networked content analysis of 9,809 posts, we identify three platformized imaginaries—systemic sustainability transitions, ethical consumer lifestyle, and zero-waste living practices. Findings reveal how platformization constrains sustainable consumption discourses, embedding them within
Aims: The European Society of Cardiology (ESC) has developed quality indicators (QIs) specifically for evaluating the care and outcomes for patients undergoing transcatheter aortic valve implantation (TAVI). The aim of this study was to evaluate TAVI care in all patients undergoing such procedures in Sweden using the ESC 2023 QIs for TAVI. Methods and results: We used the Swedish Transcatheter Car
Introduction: Adolescents are increasingly exposed to hate speech in both online and offline contexts, yet limited research has examined how such exposure is experienced and how it relates to adolescents' psychological needs and well-being. Drawing on Self-Determination Theory (SDT), this study explores how adolescents make sense of hate speech and how these experiences affect autonomy, competence
Wind energy is an important form of clean energy, and its rational utilization represents a crucial solution for mitigating the energy crisis and global warming. In this study, wind energy potential and its long-term changes in the South China Sea (SCS) are evaluated using ERA5 100 m wind data from 1944 to 2023, validated against ASCAT observations. High wind speeds and high wind power density (WP
The concept of the Viking has existed since the 7th C, while the term ‘Viking Age’ was coined in the early 19th C. The Vikings and their era represent a shared vision of a glorious past, originating from the of Romantic ear and associated with Scandinavism. Within this shared concept, the Nordic countries have been able to project their own versions of identity: in Denmark, the king or farmer; in
More than 70% of climate policies target low-carbon technologies, with hopes that policy support will trigger tipping points and self-reinforcing growth. In practice, however, trajectories of policy-driven technologies remain difficult to explain and anticipate because their growth is nonlinear and often constrained by backlash, policy reversals and systemic barriers. In this Perspective, we devel
