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The role of genomic variants in disease has expanded significantly with the advent of advanced sequencing techniques. The rapid increase in identified genomic variants has led to many variants being classified as Variants of Uncertain Significance or as having conflicting evidence, posing challenges for their interpretation and characterization. Additionally, current methods for predicting pathoge
This letter analyzes certainty-equivalence adaptive controllers for sampled-data systems through a data-driven Riccati equation. Extending a recent framework for data-driven adaptive control, the proposed formulation provides the sampled-data counterpart that explicitly accounts for intersample behavior via lifted cost representations. Sufficient conditions are derived to guarantee stability and r
The amyloid precursor protein intracellular domain (AICD) is an intrinsically disordered regulatory segment whose conserved YENPTY motif mediates transient interactions with multiple adaptor and signaling proteins. How sequence perturbations within this motif modulate its accessibility and interaction potential within a disordered ensemble remains poorly understood. Here, we combine small-angle X-
We describe the solutions to a family of rotationally symmetric second order partial differential equations in the complex plane that arises from a four-dimensional complex Lie algebra whose spanning set generates the algebra from which such generalised harmonic functions derive. We show that every one of these solutions have a canonical series representation and retrieve those obtained in the cas
Objective The basis for protein synthesis is the genetic code. Many of these proteins will affect intermediary metabolites by acting as enzymes, hormones, or by other actions. The aim of the present study was to assess the relationships of a large number of proteins with endogenous metabolites. Methods Plasma protein levels were measured by the proximity extension assay (PEA) and metabolites by ma
High-latitude ecosystems are undergoing rapid climate warming, yet long-term ecological response remain poorly understood due to the scarcity of sustained monitoring records. We analyse a unique 40-year dataset from a subarctic mountain birch ( Betula pubescens ssp. czerepanovii ) ecosystem in northern Fennoscandia, integrating climate, plant reproduction, insect herbivory, phenology, and large he
This article analyses the seasonality of births in pre-industrial Bologna between 1729 and 1860, comparing the city and the surrounding countryside and integrating long-term demographic data with meteorological information. Using Henry’s indices and regression models for the period 1814-1860, the study examines the role of temperature and precipitation during the conception period. The results ind
Stars that contain trace amounts of elements heavier than helium (that is, ‘metallicity’) preserve the chemical fingerprints of the first stars. In the Milky Way, nearly all of the lowest-metallicity stars show an extreme over-abundance of carbon. The origin of this signature has remained a mystery owing to the lack of observational constraints on the environments in which it originates. Here we p
Our aim was to study whether hospitalizations due to high alcohol consumption, as an objective indicator of high alcohol consumption, is associated with hip fractures in non-elderly adults. The participants in this study consist of 10,043 men and women in a survey study in Stockholm 1969-70, when they were 18–25 years old. We used data on hospitalization events due to a hip fracture or a diagnosis
Hybrid perovskites have demonstrated exceptional versatility as optoelectronic materials since their introduction as light absorbers and charge transport media in photovoltaic devices. These materials are now utilized in photodetectors, photocatalysis, and light-emitting devices, offering emission capabilities spanning from the ultraviolet to the mid-infrared spectrum. Recent studies in the far-in
The MAPRE3 gene is aberrantly expressed in several cancers. We profiled DNA methylation in tumor tissues from early-stage non-small cell lung cancer (NSCLC) patients and assessed associations with overall survival (OS). Significant CpG probes were validated in The Cancer Genome Atlas (TCGA). The methylation level of cg12821679MAPRE3 showed significant associations with OS in lung squamous cell car
Probing the solid/liquid interface of batteries operando/in situ with ambient pressure X-ray photoelectron spectroscopy (APXPS) using the dip-and-pull method remains a challenging endeavor due to spatial and temporal variations in liquid layer shape, thickness, and composition. Monitoring the electrochemical and topographical nature of the liquid edge where the interface is accessed is essential t
Sustainability is discussed in literature as complex, ambiguous, and partly contradictory, which makes it difficult for store personnel to fully grasp what can be classified as sustainable and how sustainability can be staged and represented in the retail grocery environment. Drawing on symbolic interactionism and Goffman’s dramaturgical perspective, this dissertation explores how sustainability iSustainability is discussed in literature as complex, ambiguous, and partly contradictory, which makes it difficult for store personnel to fully grasp what can be classified as sustainable and how sustainability can be staged and represented in the retail grocery environment. Drawing on symbolic interactionism and Goffman’s dramaturgical perspective, this dissertation explores how sustainability i
BACKGROUND: The major pathways contributing to cardiovascular disease among night shift workers remain poorly understood. MicroRNAs (miRNAs) have been identified as novel regulators of cardiovascular risk factors. Our objective was to examine whether night shift work was associated with altered expression of five cardiovascular-related miRNAs in night and day shift workers.METHODS: RNA was extract
