Purpose: Tourism faces a range of interconnected and potentially transformative global risks – collectively considered an evolving polycrisis – that have not been adequately defined and understood. As a result, the industry struggles to proactively anticipate and mitigate potential future challenges, while governments lack insight for strategic longer-term decision-making on tourism development. T

The Rodinia supercontinent broke apart during the Neoproterozoic. Rodinia break-up is associated with widespread intraplate magmatism on many cratons, including the c. 720–719 Ma Franklin large igneous province (LIP) of Laurentia. Coeval magmatism has also been identified recently in Siberia and South China. This extensive magmatism terminates ∼1 myr before the onset of the Sturtian Snowball Earth

Kollektivtrafikens bytespunkter och hållplatser än mer än platser för väntan – de utgör en central del av stadens liv och människors vardag. För att dessa kollektivtrafikrum ska bli inbjudande och tillgängliga för alla, är det viktigt att vi noggrant överväger hur de planeras och utformas. I den här boken presenteras de viktigaste aspekterna för att säkerställa att dessa platser fungerar som inklu

The share of couples where the wife outearns the husband is increasing globally. In this paper, I examine how this dynamic affects mental health. Using data on the 2001 marital cohort in Sweden, I show that while mental health is positively associated with own and spousal income, it is negatively linked to the wife’s relative income. In the most conservative specification, the wife starting to ear

We consider electromagnetic finite-volume effects through order 1/L3 in different formulations of QED, where L is the periodicity of the spatial volume.An inherent problem at this order is the appearance of structure-dependent quantities related to form factors and the analytical structure of the correlation functions.The non-local constraint of the widely used QEDL regularization gives rise to st

In Israel, the Orthodox minority enforces its conception of the good on Israeli-Jews, many of whom do not share their set of beliefs. This is the result of lack of separation between state and religion and the monopoly enjoyed by the Orthodoxy to decide personal matters. Since its establishment in 1948, Israel has been struggling to reconcile the tension between its being a democracy and retaining

Objectives: Dupuytren disease is a common condition that causes progressive finger contractures resulting in impaired hand function and difficulties in performing daily activities. Patient reported outcome measures (PROMs) are commonly used in research and clinical practice to evaluate treatment outcomes. Both general upper extremity PROMs and Dupuytren-specific PROMs are available, typically deve

The CorA/Mrs2 family of pentameric proteins are cardinal for the influx of Mg2+ across cellular membranes, importing the cation to mitochondria in eukaryotes. Yet, the conducting and regulation mechanisms of permeation remain elusive, particularly for the eukaryotic Mrs2 members. Here, we report closed and open Mrs2 cryo-electron microscopy structures, accompanied by functional characterization. M

The expected monetary value is a criterion for assessing the Value of Structural Health Monitoring (SHM) and supporting the associated decision making. Its calculation can be challenging, as it requires considering all possible outcomes of the SHM system. In this article a new approach to cost-benefit analysis for SHM systems is proposed, which is based on an estimate of the capability of the SHM

Background: The drive for home care has increasingly impacted the organization and allocation of resources within the Swedish healthcare system. Objectives: With an interest in uncovering prerequisites for palliative care, this study aimed to investigate longitudinal trends in place of death within the adult Swedish population from 2013 to 2019 and examine potential associations between place of d

The γ-tubulin (TUBG) meshwork is a central regulator of cellular architecture, orchestrating processes such as microtubule nucleation, mitochondrial organization, and genomic integrity. This study investigates the molecular impact of TUBG depletion on the cytoskeleton. Knockdown of TUBG using single guide RNA disrupted microtubule, vimentin, and lamin B networks while simultaneously reinforcing ac

Objectives To investigate the prevalence of axial spondyloarthritis (axSpA) in patients with chronic back pain (CBP) of less than 2 years (2y) duration referred to the rheumatologist, the development of diagnosis over time, and patient characteristics of those developing definite (d-)axSpA over 2y. Methods We analysed the 2y data from SPondyloArthritis Caught Early, a European cohort of patients (

Modest channel carrier mobility in SiC-MOSFETs with NO annealed gate oxides has been the main factor hampering development of low power devices (300 – 650 V). A very fast interface trap, noted as NI, has been suggested to be the main culprit for poor inversion channel carrier mobility. The origin of the NI trap is unknown, but it is likely a property of the SiO2 and it is enhanced during post nitr

Constructed with used plastic bottles, the eco-cooler has been widely adopted in resource-poor communities in Bangladesh and other countries. We tested the eco-cooler under controlled conditions using a scientific wind tunnel in a climatic chamber. In our tests, we used seven eco-cooler designs in 27 climate conditions typical of Bangladesh (temperatures of 40 °C, 35 °C, and 30 °C; humidity levels

Comprehensive resource summarizing recent research on von Willebrand disease, showing clinicians how to optimize management of patients with this disorder The newly revised and updated second edition of Textbook of von Willebrand Disease: Basic and Clinical Aspects, 2nd edition describes the important and complex role of von Willebrand factor (VWF) in hemostasis and thrombosis, covering not only t

We aimed to explore social workers’ experiential accounts of developing complex interventions for youth and families within practice settings. Social workers’ experience of developing interventions has not been leveraged in scientific research even though many complex interventions in use are developed by social workers in practice settings. Lack of insight into the intervention development proces

Background: The aim was to compare bias and precision for 177Lu-SPECT activity-concentration estimation using a dual-headed Anger SPECT system and a ring-configured CZT SPECT system. This was investigated for imaging at 208 keV and 113 keV, respectively. Methods: Phantom experiments were performed on a GE Discovery 670 system with 5/8’’ NaI(Tl) crystal (dual-headed Anger system) and a GE StarGuide

The mammary parenchyma is a complex arrangement of tissues that can greatly vary among individuals, potentially masking cancers in breast screening images. In this work, we propose a Simplex-based method to simulate anatomical patterns and textures seen in digital breast tomosynthesis. Our approach involves selecting appropriate Simplex noise parameters to represent distinct categories of breast p