Screening for prostate cancer has been advocated by a number of organisations largely because there is good evidence that administration of the test for prostate specific antigen (PSA) results in the detection of cancers at an early stage. However, the mere fact that a cancer can be detected earlier in its natural history by screening is no guarantee that benefit will follow. Further, screening fo

Serum prostate-specific antigen is credited with dramatic advances in the early detection, screening, and management of men with prostatic carcinoma. There has been more than a twofold increase in the number of men diagnosed during the last decade, and prostate cancer has emerged as the most common non-skin cancer and the second leading cause of cancer death in men. This report summarizes the hist

Here, an acoustophoresis chip is presented that is capable of separating cancer cells from white blood cells (WBCs) and subsequently concentrating the recovered cells in the same chip. The chip utilizes ultrasound standing waves in two dimensions to pre-align, separate and concentrate the cells. 92% of the cancer cells could be recovered while keeping the contamination level of WBCs to only 0.6%.

We present an improved acoustophoretic system for circulating tumor cell separation from blood. The system is operated by pressure driven flow, including flow sensors and a feed-back loop for precise flow control. The pressure driven system provides a user interface that can be handled by a non-skilled operator, and most importantly full clinical samples of 7 mL can be processed in 70 minutes. The

We have developed a microfluidic chip for isolation of circulating tumor cells (CTCs) in blood based on microchannel acoustophoresis. Ultrasound radiation forces are used to separate cancer cells from blood cells in a continuous flow format. Separation was dramatically improved after incorporation of a 2-dimensional acoustic pre-alignment of the cells before entering the acoustophoresis separation

We present a novel method for the determination of density and compressibility of individual particles and cells undergoing microchannel acoustophoresis in an arbitrary 2D acoustic field. Our method is a critical advancement within acoustophoretic separation of biological cells, as the ability to determine the density and compressibility of individual cells enables the prediction and alteration of

We present, for the first time, separation of three different prostate cancer cell lines from leukocyte fractions by means of continuous flow acoustophoresis. This flow-through separation approach, which utilize acoustophoretic forces to extract CTCs from blood has a significant advantage over affinity based methods in the sense that it comprises a non-contact and label free separation of CTCs fro

Antibody microarrays are becoming increasingly established in clinical studies. However, the arrays are seldom used in a quantitative approach but rather for detecting up or down regulated proteins. In this study we describe a microarray procedure being standardized by placing the in-house developed porous silicon surfaces into a commercially available 96 well microtiter plate for analyzing the PS

An Integrated Selective Enrichment Target (ISET), microfabricated for efficient on-bead enzymatic digestion of proteins compatible for a direct interface with matrix-assisted laser desorption /ionization mass spectrometry (MALDI MS) is presented.

Full 3" wafer scale fabrication of porous silicon chips (pore chip protein arrays -PCPA) is reported. The PCPA is developed for the analysis of protein molecules based on the fluorescence and MALDI-TOF MS detection. The surface porosification process allows the creation of chips with different surface geometries to control the physical properties of the matrix in a highly reproducible way.

Conventional fixation of large solid surgical specimens is a slow process. Consequently, autolytic damage to tissues may occur if the fixative does not reach the central part of the specimen in time. However, as there is also a time relationship between formalin fixation and antigen masking, fixation for too long can also be detrimental. In seeking the optimum balance for fixation, microwave irrad

To date, most studies on coupled-water-and-heat processes in frozen soils haves focused on the mechanism of changes in frozen soil and the contribution of climate change, hydrological processes, and ecosystems in cold regions. Several studies have demonstrated considerable improvements in the accuracy of simulating water and heat transfer processes in cold regions. However, substantial differences

Del 1 av 3 i artikelserie för Helsingborgs Dagblad om den lokala demokratin i Helsingborg inför kommunalvalet 2022.

Del 2 av 3 i artikelserie för Helsingborgs Dagblad om den lokala demokratin i Helsingborg inför kommunalvalet 2022.

Del 3 av 3 i artikelserie för Helsingborgs Dagblad om den lokala demokratin i Helsingborg inför kommunalvalet 2022.

Institutionen för kultur och samhälle vid Linköpings universitet får härmed avge yttrande som utarbetats av professorerna Anna Lundberg och Anders Neergaard.En övergripande utgångspunkt för utredningen har varit att migrationspolitiken ska vara långsiktigt hållbar, human, rättssäker och effektiv. I det följande lämnar vi synpunkter utifrån denna utgångspunkt. Vi menar sammantaget att kommittén int