Vascular Endothelial Growth Factor (VEGF) and Peripheral Nerve Regeneration
This thesis concerns vascular endothelial growth factor (VEGF) and its possible role as a neurotrophic factor. I have investigated the effect of VEGF on neurons in culture but also in vivo, following a crush lesion of the sciatic nerve, and following nerve repair. Attempts were also made to unravel the mechanism by which VEGF affects neurons and Schwann cells, using a pharmacological approach in c