There are four peptidyl-proline bonds in the 64-residue protein chymotrypsin inhibitor 2 (CI2), all of which are in the trans conformation in the native structure. The isomerisation of one or more of these peptidyl-proline bonds to the cis conformation in the denatured state gives rise to heterogeneity, leading to both fast and slow-folding species. The refolding of the fast-folding species, which

The purpose of this paper is to assess the effects, the cost efficiency, and the goal achievement of policy instruments aimed for the development and deployment of wind power in Sweden during the period 1975 to 2000. The paper presents an empirical example of a socio-technical system-based approach for impact assessment, in which changes in the wind power system are described and analysed with res

Theoretical results are presented on the absorption and fluorescence of indole in aqueous solution as well as at the air/water surface. We use a combined quantum chemical statistical mechanical model with explicit solvent. An approximate ab initio complete active space self-consistent field description of the indole molecule is used, coupled to a discrete polarizable water medium. From the bulk si

The aim of the study was to test the hypothesis that the presence of a ventriculoperitoneal shunt ( VPS) influences the frequency of postoperative complications after video-assisted gastrostomy ( VAG) in children. When using a power of 80%, a critical value for significance of 5% and an assumed population-based standard deviation of 0.4, it will be required to have a sample size of at least 14 chi

A new compact third-order scheme for the solution of the unsteady Navier-Stokes equations on unstructured grids is proposed. The scheme is a cell-based algorithm, belonging to the class of Multidimensional Upwind schemes, which uses a finite-element reconstruction procedure over the cell to achieve third order (spatial) accuracy. Derivation of the scheme is given. The asymptotic accuracy, for stea

A simplified branch metric and add-compare-select (ACS) unit is presented for use in trellis-based decoding architectures. The simplification is based on a complementary property of best feedforward and some systematic feedback encoders. As a result, one adder is saved in every other ACS unit. Furthermore, only half the branch metrics have to be calculated. It is shown that this simplification bec

The Malmo protocol for immune tolerance induction uses intermittent injections of factor VIII/IX together with intravenous IgG and cyclophosphamide. In order to increase the production of antigen-antibody complexes, and also to improve cost-efficacy, we applied continuous infusion instead of intermittent injection in 5 high-responders (3 hemophilia A and 2 hemophilia B). All treatment attempts fai

Identifying genes involved in the disease pathways of complex diseases such as Rheumatoid arthritis (RA) has been shown to be very difficult. Despite decades of research still only a handful of genes have been convincingly identified as risk genes. RA is a common autoimmune disorder that affects approximately 1% of the population and knowledge of the contributing genetic factors would greatly incr

The recent demostration that neurons for transplantation can be generated from stem cells and that the adult brain produces new neurons in response to stroke has raised hope for the development of a stem cell therapy for patients affected with this disorder. In this review we propose a road map to the clinic and describe the different scientific tasks that need to be accomplished to move stem cell

The avian circadian and visual systems are integrally related and together influence many aspects of birds' behavior and physiology. Certainly, light cycles and their visual perception are the major zeitgebers for circadian rhythms, but do circadian rhythms affect vision? To assess whether visual func-tion is regulated on a circadian basis, flash-evoked electroretinograms (ERGs) and vision-evoked

A Swedish family with two generations suffering from presenile dementia with an unusually severe Alzheimer encephalopathy was first reported in 1946. The hypothesis that the disease was inherited through a dominant gene is strongly supported by the follow-up 50years later of three additional generations and molecular genetic findings of a novel presenilin-1 gene mutation in the family. The pedigre

A relativistic extension is made of methods by which intermediate coupling amplitudes are deduced from measured energy levels and combined with measured lifetimes to obtain transition probabilities within a multiplet between two pure configurations. A procedure for incorporating the relativistic j-dependence of the radial transition integral into the empirical data reduction is presented and appli

Objective-Recent studies failed to show long-term benefit with low-molecular weight heparins (LMWH) in unstable coronary heart disease. A previous study of vascular effects of the cytostatic agent 5-fluorouracil (5-FU) showed that dalteparin prevented thrombosis induced by 5-FU but endothelial damage was not ameliorated and was present also in animals treated with dalteparin only. This study inves

A purified 75-kDa myrosinase and a crude rapeseed myrosinase fraction were used as antigens to produce mouse anti-myrosinase monoclonal antibodies. The 75-kDa myrosinase was also used to produce a polyclonal rabbit antiserum. The antiserum and one monoclonal antibody reacted with three distinct rapeseed polypeptides of 75, 70 and 65 kDa (M75, M70 and M65, respectively). A second set of monoclonal

Following a brief account of the main events in the life of Rāmānuja according to traditional hagiographical works, the article examines the fundamental exegetical, epistemological, ontological and soteriological positions of this medieval thinker. These views are contrasted mainly with those of the greatly influential Śaṅkara some centuries earlier, particularly with respect to the conflict betwe

The hydration (or solvation) of the lithium, sodium, fluoride, and chloride ions are investigated using a combined quantum chemical statistical mechanical model. Radial distribution functions and the distribution of coordination numbers are reported and compared with other recent studies. An algorithm to investigate the geometry of the first solvation shell is proposed and applied to the four hydr