Knowledge about the natural history of severe alpha 1-antitrypsin (AAT) deficiency (PiZZ) is limited. Our aim was to compare the survival of PiZZ individuals with randomly selected controls from the Swedish general population. The PiZZ subjects (n=1585) were selected from the Swedish National AATD Register. The controls (n=5999) were randomly selected from the Swedish population register. Smoking

The ESS Linac project, phase I, requires 12 long pulse klystron modulators with compact footprint, high pulse power and improved quality both on the output pulse waveform and on the input AC power line. Conventional long pulse modulators are typically based on HV pulse transformers and commonly exhibit poor efficiency, low power density, large footprint and cost, with still limited performance on

Effects of the bluff-body's position on diffusion flame structures and flame instability characteristics were investigated experimentally. A flame regime diagram together with the corresponding flow fields were proposed to evaluate the influences caused by the alternation of bluff-body's position. The disk shape bluff-body was placed 10 mm downstream or at the same height with the annular channel

Sustainable development remains of general interest in both political and academic circles. Importantly, the approach to collective decision making adopted in pursuit of sustainable development has importance repercussions regarding what range of possible informational considerations get incorporated as relevant to a given choice exercise. The most dominant approach to environmental public policy

In this work, eleven different combinations of work piece materials and tool grades have been evaluated in wear test when turning with cemented carbide insert. The most commonly used tool life models such as the Taylor model, the Extended Taylor model, the Coromant Turning model version 1 and the Colding model have been tested on the data and their accuracy is presented. The well-known Taylor mode

The article is based on my contribution to the Phenomenology and Aesthetics seminar at the University of Riga 29 Jun - 1 July 2017, where I compared Edith Stein's theory about Empathy (Einfühlung) with Stanislavski's conception of scenic action as perspective taking.

Coal has been the main fuel in the generation of heat and power for many years and will continue to be so for years to come. Global warming awareness has led to the Kyoto Protocol, which targets the abatement of six greenhouse gases, including carbon dioxide (CO2). For the abatement of CO2 emissions, co-combustion of coal and biomass is an attractive solution. Other mitigation solutions include ox

Texten är en översättning av Edith Steins doktorsavhandling, Zum Problem der Einfühlung, publicerad 1917

Polyvinyl chloride (PVC) is a common thermoplastic whichfinds widespread applications in the construction industry for usage inceiling linings, flooring materials, electrical cables and roofing materials. Several fire requirements are put on these types of applications. For fire safety engineering and product development, thermo-chemical decomposition modeling of PVC isrequired. The FIRETOOLS proj

Background--Atherosclerosis is an inflammatory lipid disorder and the main underlying pathology of acute ischemic events. Despite a vast amount of data from murine atherosclerosis models, evidence of B-cell involvement in human atherosclerotic disease is limited. We therefore investigated the association of circulating B-cell subtypes with the occurrence of secondary cardiovascular events in advan

Dysregulation of gene expression in islets from type 2 diabetic patients might be causally involved in the development of hyperglycemia or it could develop as a consequence of hyperglycemia, i.e. glucotoxicity. To separate the genes potentially causally involved in pathogenesis from those likely to be secondary to the hyperglycemia we exposed islets from human donors to normal or high glucose conc

Gestational diabetes mellitus(GDM) defines an unhealthy state of hyperglycaemia that develops in response to an otherwise normal physiological adaptive insulin resistance state during pregnancy. However, the exact plasma glucose levels differentiating the unhealthy GDM state from a normal pregnancy is unknown, and relies upon arbitrary cut off criteria based on associations with adverse health out

BACKGROUND AND PURPOSE: There are, to date, no MR imaging diagnostic markers for Lewy body dementia. Nigrosome 1, containing dopaminergic cells, in the substantia nigra pars compacta is hyperintense on SWI and has been called the swallow tail sign, disappearing with Parkinson disease. We aimed to study the swallow tail sign and its clinical applicability in Lewy body dementia and hypothesized that

Diffusion tensor imaging (DTI) has been used to study microstructural white matter alterations in a variety of conditions including normal aging and Alzheimer’s disease (AD). White matter hyperintensities (WMH) are common in cognitively healthy elderly as well as in AD and exhibit elevated mean diffusivity (MD) and reduced fractional anisotropy (FA). However, the effect of WMH on statistical analy

Om Elsa Collin: student, författare, journalist.

Background: Glioblastoma is the most common and aggressive type of primary brain tumor in adults. A key problem is the capacity of glioma cells to inactivate the body’s immune response. The complement system acts as a functional bridge between the innate and adaptive immune response. Still, the role of the complement system has almost been forgotten in glioma research. In our present study, we hyp

Hypertension is a hemodynamic disorder and one of the most important and well-established risk factors for vascular diseases such as stroke. Blood vessels exposed to chronic shear stress develop structural changes and remodeling of the vascular wall through many complex mechanisms. However, the molecular mechanisms involved are not fully understood. Hypertension-susceptible genes may provide a nov

I början av 1930-talet var nära 200 000 kvinnor anställda som hembiträden i svenska hushåll, men många var missnöjda med sin arbetssituation. Under hotet om deras flykt från yrket aktualiserades genom en motion i Sveriges riksdag 1931 den så kallade hembiträdesfrågan, som skulle bli ett hett debattämne in i nästa decennium. Året därpå fick den svenska ljudfilmen sin första stora braksuccé: Vi som