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Increased expression of endothelin receptor type B (ETBR), a vasoactive receptor, has recently been implied in the reduced cerebral blood flow and exacerbated neuronal damage after ischemia-reperfusion (I/R). The study explores the regulatory mechanisms of ETBR to identify drug targets to restore normal cerebral artery contractile function as part of successful neuroprotective therapy.
Background: Weight loss is a common problem in patients with Squamous Cell Carcinoma of the Head and Neck (SCCHN) treated with radiotherapy (RT). The aims of the present study were to determine if treated volume (TV), as a measure of the radiation dose burden, can predict weight loss in patients with oropharyngeal cancer and to analyze weight loss and body mass index (BMI) in the same patient grou
A new type of treatment planning system called SHAREPLAN has been studied, which enables the transfer of treatment plans generated for helical tomotherapy delivery to plans that can be delivered on C-arm linacs. The purpose is to ensure continuous patient treatment during periods of unscheduled downtime for the TomoTherapy unit, particularly in clinics without a backup unit. The purpose of this wo
We show here, by using surface biotinylation, followed by Western blotting or surface plasmon resonance analysis, that very low levels of S100A8 and/or S100A9 can be detected on the surface of THP-1 cells or freshly isolated human monocytes. This was supported by immune-electron microscopy where we observed membrane-associated expression of the proteins restricted to small patches. By using confoc
The ternary Zintl phase Ca3Ag1+xGe3x (x = 1/3) was synthesized by the high-temperature solid-state technique and its crystal structure was refined from single-crystal diffraction data. The compound Ca3Ag1.32Ge2.68(1) adopts the Sc3NiSi3 type structure, crystal data: space group C2/m, a = 10.813(1) angstrom, b = 4.5346(4) angstrom, c = 14.3391(7) angstrom, beta = 110.05(1)degrees and V = 660.48(10)
Två helt olika alternativa möjligheter att förkorta torktiderna för byggfukt i betonggolv har undersökts. Den ena möjligheten var att försöka utnyttja de resultat som erhållits i ett antal tidigare projekt där det visat sig att fuktbelastningen på ett mer eller mindre tätt ytskikt under vissa förhållanden varit mycket lägre efter omfördelning av kvarvarande byggfukt än vad man kunde förvänta sig
Microscopic colitis (MC) is a disease with intestinal mucosal inflammation causing diarrhea, affecting predominantly middle-aged women. The etiology is unknown, but increased prevalence of autoimmune diseases in these patients has been described, although not compared with controls or adjusted for confounding factors. The aim of this study was to examine the prevalence of common diseases in patien
Popular Abstract in Swedish Förekomsten av hudcancer ökar i ljushyade befolkningsgrupper och hudcancer tillhör de cancergrupper som ökar mest i Sverige. De tre vanligaste formerna av hudcancer är basalcellscancer, skivepitelcancer och malignt melanom. Under 2013 utgjorde skivepitelcancer och malignt melanom ca 16 % av alla cancerfall som rapporterades in till Svenska Cancerregistret; över 6 000 faSkin cancer incidence is increasing in fair-skinned populations. The three most common skin cancers are basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM). A correct diagnosis is crucial for an efficient and tailored treatment for the skin cancer patient. The purpose of this thesis was to evaluate different aspects of the preoperative diagnosis of skin cancer. Th
Scenario: Using adaptive dynamic theory, expose a monomorphic prey population to two habitat types and a visual predator. Questions: What circumstances can lead to the evolution of polymorphic crypsis? How is the outcome affected by the dispersal pattern of the prey and predator, by the amount of predation, and by the trade-off strength between the habitats? Mathematical method: I modelled three d
Submerged macrophytes play a key role in the functioning of stream ecosystems since they strongly affect the biological and physical environment of the habitat. On the other hand, flow velocity may affect growth and establishment of submerged macrophytes in streams and rivers. However, little attention has been paid to the morphological responses of submerged macrophytes to different stream flows
The main question of this thesis is if a practice is right because it is prescribed by an ethical theory, or if an ethical theory is right because it follows from certain practices? I propose the following definitions to illustrate the main alternatives: (1) if a practice is determined by an ethical theory and the ethical theory is not determined by practice, it is possible to speak of a top-down
A general coupling-based model framework for wideband multiple-input multiple-output (MIMO) channels is presented in this paper. Under this framework, the channel state information (CSI) tensor can be expressed by the product of a coupling tensor, a complex Gaussian tensor and three unitary matrices. The unitary matrices can be either eigenbases or steering matrices in different domains. The coupl
The article is a response to a lecture held by Sarah Coakley at Lund University 2009. In relation to Coakley's reflections on pain, the article addresses the question whether the Passion story still today, and not only in an ecclesial context, can serve as an incitement to a kind of self-examinating reflection. In other words, is it possible to retrieve through the Passion a narrative framework wh
Ever since the term ‘gentrification’ was coined by Ruth Glass in 1964 this specific form of socio-economic change has attracted much attention within the social sciences, not least from geographers and sociologists. This has generated a rich discussion on the mechanisms behind the process and, to a lesser extent, a debate on positive and negative outcomes of gentrification. Critical voices have de
Aim: Colorectal cancer is the third most common form of cancer in the industrial countries. Due to advances regarding the treatments, primarily development of improved surgical methods and the ability to make the earlier diagnosis, the mortality has remained constant during the past decades even though the incidence in fact has increased. To improve chemotherapy and enable personalised treatment,
Background: Synaptic degeneration is an early pathogenic event in Alzheimer's disease, associated with cognitive impairment and disease progression. Cerebrospinal fluid biomarkers reflecting synaptic integrity would be highly valuable tools to monitor synaptic degeneration directly in patients. We previously showed that synaptic proteins such as synaptotagmin and synaptosomal-associated protein 25
